Protein Alignment grh and GRHL1

DIOPT Version :9

• Sequence 1: NP_476845.2
• Gene: grh / 37038
• FlyBaseID: FBgn0259211
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: XP_006711945.1
• Gene: GRHL1 / 29841
• HGNCID: 17923
• Length: 630
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 188/575 - (32%)
• Similarity: 270/575 - (46%)
• Gaps: 157/575 - (27%)

  Fly   833 GTLIDANGSIPVSV-----NSIQQRTAVHG---------SQNSPTTSLVDTSTNGST-------- 875
            |.|...:.::.||:     :||:..|..||         ....||..:|....|.:|
Human   136 GHLTAPDTTVTVSIATMPTHSIKTETQPHGFAVGIPPAVYHPEPTERVVVFDRNLNTDQFSSGAQ 200

  Fly   876 -----RSRPWHDFGR--QNDADKIQIPK--------------IFTNV---GFRYHLESPISSSQR 916
                 |..|...|..  :....::..|.              :|.:|   .|.|.||:..|..|:
Human   201 APNAQRRTPDSTFSETFKEGVQEVFFPSDLSLRMPGMNSEDYVFDSVSGNNFEYTLEASKSLRQK 265

  Fly   917 REDDRITYINKGQFYGITLEYVHDAE---KPIKNTTVKSVIMLMFREEKSPEDEIKAWQFWHSRQ 978
            ..|..:||:||||||.|||:.|..:|   .||  :.|:||||::|.|:||.||:::.|::|||||
Human   266 PGDSTMTYLNKGQFYPITLKEVSSSEGIHHPI--SKVRSVIMVVFAEDKSREDQLRHWKYWHSRQ 328

  Fly   979 HSVKQRILD-ADTKNSVGLVGCIEEVSHNAIAVYWNPLESSAKINIAVQCLSTDFSSQKGVKGLP 1042
            |:.|||.:| ||.|.|...:..|||:::|||:..|: :...||:.|:|.||||||||||||||||
Human   329 HTAKQRCIDIADYKESFNTISNIEEIAYNAISFTWD-INDEAKVFISVNCLSTDFSSQKGVKGLP 392

  Fly  1043 LHVQIDTFE-DPRDTAVFHRGYCQIKVFCDKGAERKTRDEERRAAKRKMTATGRKKLDELYHPVT 1106
            |::|:||:. :.|.....||.|||||||||||||||.|||||:.:|||
Human   393 LNIQVDTYSYNNRSNKPVHRAYCQIKVFCDKGAERKIRDEERKQSKRK----------------- 440

  Fly  1107 DRSEFYGMQDFAKPPVLFSPAEDMEKVGQLGIGAATGMTFNPLSNGNSNSN-------SHSSLQS 1164
                                                |...:|.|..|:.|:       ||..:
Human   441 ------------------------------------GKCPDPSSQVNAFSDVKVPLLPSHKRM-- 467

  Fly  1165 FYGHETDSPDLKGASPFL-LHGQKVATPTLKFHNHFPPDM---QTDKKDHILDQNMLTSTPLTDF 1225
                     |:....||: |..|.|.         |.||:   ...:..|:|.   :.|..|...
Human   468 ---------DITVFKPFIDLDTQPVL---------FIPDVHFANLQRGTHVLP---IASEELEGE 511

  Fly  1226 GPPMKRGR-------MTPPTS--------ERVMLYVRQENEEVYTPLHVVPPTTIGLLNAIENKY 1275
            |..:|||.       ..||::        :||:||||:|:|||:..|.:..|:..||:.||.:||
Human   512 GSVLKRGPYGTEDDFAVPPSTKLARIEEPKRVLLYVRKESEEVFDALMLKTPSLKGLMEAISDKY 576

  Fly  1276 KISTTSINNIYRTNKKGITAKIDDDMISFYCNEDIFLLEVQQIEDDLYDVTLTEL 1330
            .:....|..|::..||||...:||:::..|.|||.|.|::::.... |.:||||:
Human   577 DVPHDKIGKIFKKCKKGILVNMDDNIVKHYSNEDTFQLQIEEAGGS-YKLTLTEI 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
grh	NP_476845.2	CP2	903..1089	CDD:282385	103/190 (54%)
GRHL1	XP_006711945.1	CP2	235..442	CDD:282385	107/262 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	202	1.000	Domainoid score	I2986
eggNOG	1	0.900	-	-		E1_KOG4091
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001445
OrthoInspector	1	1.000	-	-		otm41194
orthoMCL	1	0.900	-	-		OOG6_104596
Panther	1	1.100	-	-	LDO	PTHR11037
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3190
SonicParanoid	1	1.000	-	-		X907
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.840