Protein Alignment grh and Grhl3

DIOPT Version :9

• Sequence 1: NP_476845.2
• Gene: grh / 37038
• FlyBaseID: FBgn0259211
• Length: 1333
• Species: Drosophila melanogaster
• Sequence 2: NP_001013778.1
• Gene: Grhl3 / 230824
• MGIID: 2655333
• Length: 603
• Species: Mus musculus
• Alignment Length: 570
• Identity: 171/570 - (30%)
• Similarity: 254/570 - (44%)
• Gaps: 140/570 - (24%)

  Fly   819 NIQQSFDYTELCQPGTLIDANGSIPV--SVNSI-----QQRTAVHGSQNSPTTSLVDTSTNGSTR 876
            |:..|.|||:..:...|:...|.:|.  ..|::     :...:...|...|.:.:.|   |||..
Mouse   116 NVSGSPDYTDQLKKNNLLGLEGVLPTPGKTNTVPPGPSKLEASSMDSYLLPASDIYD---NGSLN 177

  Fly   877 S-----------RPWHDFGRQNDA---DKIQIPKIFTNV------------------GFRYHLES 909
            |           :.|     |.|:   |..|...:|.::                  .|.|.|.|
Mouse   178 SLFESIHGVPPTQRW-----QPDSTFKDDPQESLLFPDILKTSPDPPCPEDYPGLKSDFEYTLGS 237

  Fly   910 PISSSQRREDDRITYINKGQFYGITLEYVHDAE-KPIKNTTVKSVIMLMFREEKSPEDEIKAWQF 973
            |.:...:..:..:.|:||||||.:||......: ..:.::.||||:|::|..:|.|.::::.|:.
Mouse   238 PKAIHIKAGESPMAYLNKGQFYPVTLRTPAGGKGLALSSSKVKSVVMVVFDNDKVPVEQLRFWRH 302

  Fly   974 WHSRQHSVKQRILD-ADTKNSVGLVGCIEEVSHNAIAVYWNPLESSAKINIAVQCLSTDFSSQKG 1037
            |||||.:.|||::| ||.|.:...|..||||::||::..|| :...||:.|.|.|||||||||||
Mouse   303 WHSRQPTAKQRVIDVADCKENFNTVQHIEEVAYNALSFVWN-VNEEAKVFIGVNCLSTDFSSQKG 366

  Fly  1038 VKGLPLHVQIDTFEDPRDT-AVFHRGYCQIKVFCDKGAERKTRDEERRAAKRKMTA--------- 1092
            |||:||::||||::....| .:.||..||||:|||||||||.||:||:..:||:..
Mouse   367 VKGVPLNLQIDTYDCGAGTERLVHRAVCQIKIFCDKGAERKMRDDERKQFRRKVKCPDSSNNAGI 431

  Fly  1093 -----TGRKKLDELY-HPVTDRSEFYGMQDFAKPPVLFSPAEDMEKVGQLGIGAATGMTFNPLSN 1151
                 :|.:..:..| .|.|         |....||||.|
Mouse   432 KGCLLSGFRGNETTYLRPET---------DLETQPVLFIP------------------------- 462

  Fly  1152 GNSNSNSH-SSLQSFYGHETDSPDLKGASPFLLHGQKVATPTLKFHNHFPPDMQTDKKDHILDQN 1215
                 |.| ||||        .|.  |..|...|......|..:
Mouse   463 -----NLHFSSLQ--------RPG--GVVPSAGHSSSDRLPLKR--------------------- 491

  Fly  1216 MLTSTPLTDFGPPMKRGRMTPPTSERVMLYVRQENEEVYTPLHVVPPTTIGLLNAIENKYKISTT 1280
              |.:|..:...|:...:......:||:||||:|.|||:..|.:..|...||.|||..||.:...
Mouse   492 --TCSPFAEEFEPLPSKQAKEDDLQRVLLYVRRETEEVFDALMLKTPDLKGLRNAISEKYGLPEE 554

  Fly  1281 SINNIYRTNKKGITAKIDDDMISFYCNEDIFLLEVQQIEDDLYDVTLTEL 1330
            :|..:|:..|:||...:|:::|..|.|...|||::.:: |....:.|.||
Mouse   555 NICKVYKKCKRGILVNMDNNIIQHYSNHVAFLLDMGEL-DGKIQIILKEL 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
grh	NP_476845.2	CP2	903..1089	CDD:282385	88/188 (47%)
Grhl3	NP_001013778.1	Transcription activation. /evidence=ECO:0000250|UniProtKB:Q8TE85	30..95
		CP2	213..421	CDD:282385	90/208 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I3026
eggNOG	1	0.900	-	-		E1_KOG4091
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001445
OrthoInspector	1	1.000	-	-		otm43259
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X907
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.910