DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment grh and Ubp1

DIOPT Version :9

Sequence 1:	NP_476845.2	Gene:	grh / 37038	FlyBaseID:	FBgn0259211	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	XP_006512113.3	Gene:	Ubp1 / 22221	MGIID:	104889	Length:	649	Species:	Mus musculus

Alignment Length:	608	Identity:	132/608 - (21%)
Similarity:	231/608 - (37%)	Gaps:	150/608 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   801 PSPDSGIGTDAITPRDQTNIQQ--------------SFDYTELCQPGTLIDANGSIPVSVNSIQQ 851
            |.|.||....|..|..:|...:              |.|  |:.:.|.:.|.:.|:    :.|.|
Mouse    59 PRPPSGRARGARAPSPRTRRPRCAGRRRGRKMAWVLSMD--EVIESGLVHDFDSSL----SGIGQ 117

  Fly   852 RTAVHGSQNSPTTSLVDTSTNGSTRSRPWHDFGRQNDA-----DKIQIPKIFTNVGFRYHLESPI 911
            .........|...:|               ...:|.|:     |:.:.|.      |:|.:.:..
Mouse   118 ELGAGAYSMSDVLAL---------------PIFKQEDSSLSLEDEAKHPP------FQYVMCAAT 161

  Fly   912 SSSQRREDDRITYINKGQFYGI-TLEYVHDAEKP-IKNTTVKSVIMLMFREEK---SPEDEIKAW 971
            |.:.:..|:.:||:|:||.|.| .|:.....:.| :....|||:|.::|.:.:   :...:::.|
Mouse   162 SPAVKLHDETLTYLNQGQSYEIRMLDNRKMGDMPELSGKLVKSIIRVVFHDRRLQYTEHQQLEGW 226

  Fly   972 QFWHSRQHSVKQRILDADTKNSVGLVGCIEEVSH-NAIAVYWNPLESSAKINIAVQCLSTDFSSQ 1035
            : |    :....|:||.|...|||::......|. ||:...|:|.:.::.. |.|.|:||:|:.:
Mouse   227 K-W----NRPGDRLLDLDIPMSVGIIDTRTNPSQLNAVEFLWDPAKRTSAF-IQVHCISTEFTPR 285

  Fly  1036 K--GVKGLPLHVQIDTF---EDPRDTAVFHRGYCQIKVFCDKGAERKTRDEERRAAKRKMTATGR 1095
            |  |.||:|..:|:|||   |:...|...|...||||||..|||:||.:::..:..||  ||..:
Mouse   286 KHGGEKGVPFRIQVDTFKQNENGEYTDHLHSASCQIKVFKPKGADRKQKNDREKMEKR--TAHEK 348

  Fly  1096 KKLDELY----------HPVTDRSEFYGMQDFAKPPVLFSPAEDMEKVGQLGI-----GAATGMT 1145
            :|....|          .|:.:.:..:..:..:|..:   ||:..:.:.:.|.     ...|...
Mouse   349 EKYQPSYDTTILTEMRLEPIIEDAVEHEQKKSSKRTL---PADYGDSLAKRGSCSPWPDTPTAYV 410

  Fly  1146 FNPLSNGNSNSNSHSSLQSFYGHETDSPDLKGASPFLLHGQKV------------------ATPT 1192
            .|..|...:.::|..|..|.....:.||:.:|.......|:::                  ::.|
Mouse   411 NNSPSPAPTFTSSQPSTCSVPDSNSSSPNHQGDGAAQASGEQIQPSATTQETQQWLLKNRFSSYT 475

  Fly  1193 LKFHNHFPPDMQTDKKDHILD----------QNMLTSTPLTDFGPPMKRGRMTPPTSERVMLYVR 1247
            ..|.|....|:....|:.::.          .|.|.|             |...|   |:.:||.
Mouse   476 RLFSNFSGADLLKLTKEDLVQICGAADGIRLYNSLKS-------------RSVRP---RLTIYVC 524

  Fly  1248 QE-----------------------NEEVYTPLHVVPPTTIGLLNAIENKYKISTTSINNIYRTN 1289
            ||                       ...||..:::.......:...:.:.:.|....||.:||..
Mouse   525 QEQPSSTALQGQPQAAGSGGESGGGTPSVYHAIYLEEMVASEVARKLASVFNIPFHQINQVYRQG 589

  Fly  1290 KKGITAKIDDDMISFYCNEDIFL 1312
            ..||...:.|.|:..:.:|..||
Mouse   590 PTGIHILVSDQMVQNFQDETCFL 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grh	NP_476845.2	CP2	903..1089	CDD:282385	62/196 (32%)
Ubp1	XP_006512113.3	CP2	139..343	CDD:367976	64/215 (30%)
Ubp1	XP_006512113.3	SAM_LBP1	458..524	CDD:188987	12/81 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4091
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810