DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment grh and Grhl1

DIOPT Version :9

Sequence 1:	NP_476845.2	Gene:	grh / 37038	FlyBaseID:	FBgn0259211	Length:	1333	Species:	Drosophila melanogaster
Sequence 2:	NP_001154878.1	Gene:	Grhl1 / 195733	MGIID:	2182540	Length:	618	Species:	Mus musculus

Alignment Length:	666	Identity:	208/666 - (31%)
Similarity:	307/666 - (46%)	Gaps:	155/666 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   733 PPPATTTVLTSVHHHQQQ-----------QQQQQQHQQQQQQQQHHQQQQHHSQDGKSNGGATPL 786
            |..|.|..:.|::..:..           :..:::.....:.:..|.:.:|..::...|....||
Mouse    40 PLTAATKAMMSINGDEDSAAALGLLYDYYKVPRERRSSAVKPEGEHPEPEHSKRNSIPNVTEQPL 104

  Fly   787 YAKAITAAGLTVDLPSPDSGIGTDAITPRDQTNIQQSFDYTELCQPGTLIDANGSIPVSV----- 846
            .:.......:..::|       .:.:.|...   |...|     :.|.|...:.::.||:
Mouse   105 ISAGENRVQVLKNVP-------FNIVLPHSN---QLGID-----KRGHLTAPDTTVTVSIATMPT 154

  Fly   847 NSIQQRTAVHG---------SQNSPTTSLV--------DTSTNG-----STRSRPWHDFGR--QN 887
            :||:.....||         ..:.||..:|        |..::|     :.|..|...|..  :.
Mouse   155 HSIKTEIQPHGFAVGIPPAVYHSEPTERVVVFDRSLSTDQFSSGTQPPNAQRRTPDSTFSETFKE 219

  Fly   888 DADKIQIPK--------------IFTNV---GFRYHLESPISSSQRREDDRITYINKGQFYGITL 935
            ...::..|.              :|.||   .|.|.||:..|..|::.|..:||:||||||.:||
Mouse   220 GVQEVFFPSELSLRMPGMNSEDYVFDNVSGNNFEYTLEASKSLRQKQGDSTMTYLNKGQFYPVTL 284

  Fly   936 ------EYVHDAEKPIKNTTVKSVIMLMFREEKSPEDEIKAWQFWHSRQHSVKQRILD-ADTKNS 993
                  |.:|   .||  :.|:||||::|.|:||.||:::.|::||||||:.|||.:| ||.|.|
Mouse   285 KEGSSNEGIH---HPI--SKVRSVIMVVFAEDKSREDQLRHWKYWHSRQHTAKQRCIDIADYKES 344

  Fly   994 VGLVGCIEEVSHNAIAVYWNPLESSAKINIAVQCLSTDFSSQKGVKGLPLHVQIDTFE-DPRDTA 1057
            ...:..|||:::|||:..|: :...||:.|:|.|||||||||||||||||::||||:. :.|...
Mouse   345 FNTISNIEEIAYNAISFTWD-INDEAKVFISVNCLSTDFSSQKGVKGLPLNIQIDTYSYNNRSNK 408

  Fly  1058 VFHRGYCQIKVFCDKGAERKTRDEERRAAKRKMTATGRKKLDELYHPVTDRSEFYGMQDFAKPPV 1122
            ..||.|||||||||||||||.|||||:.:|||::....:.|..  |..||.:.|....|....||
Mouse   409 PVHRAYCQIKVFCDKGAERKIRDEERKQSKRKVSDVKVQLLPS--HKRTDITVFKPFLDLDTQPV 471

  Fly  1123 LFSPAEDMEKVGQLGIGAATGMTFNPLSNGNSNSNSH-SSLQSFYGHETDSPDLKGASPFLLHGQ 1186
            ||.|                .:.|..|..|     || .||        .|.:|:|....|..|
Mouse   472 LFIP----------------DVHFTNLQRG-----SHVLSL--------PSEELEGEGSVLKRG- 506

  Fly  1187 KVATPTLKFHNHFPPDMQTDKKDHILDQNMLTSTPLTDFG--PPMKRGRMTPPTSERVMLYVRQE 1249
                          |....|                 |||  ||.|..|...|  :||:||||:|
Mouse   507 --------------PFGTED-----------------DFGVPPPAKLTRTEEP--KRVLLYVRKE 538

  Fly  1250 NEEVYTPLHVVPPTTIGLLNAIENKYKISTTSINNIYRTNKKGITAKIDDDMISFYCNEDIFLLE 1314
            :|||:..|.:..|:..||:.||.:||.:....|..|::..||||...:||:::..|.|||.|.|:
Mouse   539 SEEVFDALMLKTPSLKGLMEAISDKYDVPHDKIGKIFKKCKKGILVNMDDNIVKHYSNEDTFQLQ 603

  Fly  1315 VQQIEDDLYDVTLTEL 1330
            :::.... |.:||||:
Mouse   604 IEEAGGS-YKLTLTEI 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
grh	NP_476845.2	CP2	903..1089	CDD:282385	103/193 (53%)
Grhl1	NP_001154878.1	Transcription activation. /evidence=ECO:0000250\|UniProtKB:Q8K5C0	1..91		5/50 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..100		3/23 (13%)
		CP2	235..440	CDD:282385	106/210 (50%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:Q9NZI5	380..389		8/8 (100%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:Q9NZI5	427..430		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I3026
eggNOG	1	0.900	-	-		E1_KOG4091
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001445
OrthoInspector	1	1.000	-	-		otm43259
orthoMCL	1	0.900	-	-		OOG6_104596
Panther	1	1.100	-	-	LDO	PTHR11037
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3190
SonicParanoid	1	1.000	-	-		X907
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.840