DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhit and RGS11

DIOPT Version :9

Sequence 1:	NP_611271.3	Gene:	Dhit / 37037	FlyBaseID:	FBgn0028743	Length:	274	Species:	Drosophila melanogaster
Sequence 2:	XP_011521021.1	Gene:	RGS11 / 8786	HGNCID:	9993	Length:	499	Species:	Homo sapiens

Alignment Length:	170	Identity:	62/170 - (36%)
Similarity:	87/170 - (51%)	Gaps:	27/170 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 CCCSCSWAKCLAIKNADE----NAPTKRDLVNAEFLDGEQPTLEEIRSWGKSFDKLMKSTAGRKV 155
            |..|..|     |.:.|.    ||||    |.|       ||...:..||.||.:|::...||..
Human   300 CLPSNPW-----ISDNDAYWVMNAPT----VAA-------PTKLRVERWGFSFRELLEDPVGRAH 348

  Fly   156 FQNFLRSEFSEENILFWLACEDLK---KENSPELVEEKARLIYEDYISILSPREVSLDSRVREIV 217
            |.:||..|||.||:.||.|||:|:   :...|.||:    .:||.:::..:...|::|||..|..
Human   349 FMDFLGKEFSGENLSFWEACEELRYGAQAQVPTLVD----AVYEQFLAPGAAHWVNIDSRTMEQT 409

  Fly   218 NRNMIEPTTHTFDEAQIQIYTLMHRDSYPRFLNSQKFKTL 257
            ...:.:|..:..|:||:.||.||.:|||||||.|..:|.|
Human   410 LEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDMYKAL 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhit	NP_611271.3	RGS_RZ-like	139..256	CDD:188673	47/119 (39%)
RGS11	XP_011521021.1	DEP_RGS7-like	24..106	CDD:239897
		GGL	255..316	CDD:128520	5/20 (25%)
		RGS_RGS11	327..452	CDD:188694	49/127 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810