DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhit and AXIN1

DIOPT Version :9

Sequence 1:	NP_611271.3	Gene:	Dhit / 37037	FlyBaseID:	FBgn0028743	Length:	274	Species:	Drosophila melanogaster
Sequence 2:	XP_011520984.1	Gene:	AXIN1 / 8312	HGNCID:	903	Length:	916	Species:	Homo sapiens

Alignment Length:	206	Identity:	55/206 - (26%)
Similarity:	84/206 - (40%)	Gaps:	34/206 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PTVGGSVGILGSTSNVLQESNATTFQRPQSQKPCCFCWCCCCSCSWAKCLAIKNADENA-PTKRD 119
            |.|.|..|.|.||                ..:|..:.:|.      .|.:.||.....| |.:.|
Human    72 PPVPGEEGELVST----------------DPRPASYSFCS------GKGVGIKGETSTATPRRSD 114

  Fly   120 LVNAEFLDGEQPTLEEIRSWGKSFDKLMKSTAGRKVFQNFLRSEFSEENILFWLACEDLKKENSP 184
            |......:|..........|.:|...|:....|..:|:.||:.|...:.:.||.||...:|....
Human   115 LDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPC 179

  Fly   185 ELVEEK----ARLIYEDYI----SILSPR-EVSLDSRVREIVNRNMIEPTTHTFDEAQIQIYTLM 240
            :..|||    ||.||..||    .|:|.: :.:..|.::..:.:.:|:|.  .||:||.:|...|
Human   180 DSNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPA--MFDQAQTEIQATM 242

  Fly   241 HRDSYPRFLNS 251
            ..::||.||.|
Human   243 EENTYPSFLKS 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhit	NP_611271.3	RGS_RZ-like	139..256	CDD:188673	38/122 (31%)
AXIN1	XP_011520984.1	Axin_TNKS_binding	60..129	CDD:211424	17/78 (22%)
		RGS_Axin	138..258	CDD:188662	36/118 (31%)
		Axin_b-cat_bind	518..574	CDD:285982
		DIX	836..911	CDD:279160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810