DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhit and Rgs12

DIOPT Version :9

Sequence 1:	NP_611271.3	Gene:	Dhit / 37037	FlyBaseID:	FBgn0028743	Length:	274	Species:	Drosophila melanogaster
Sequence 2:	XP_006504183.1	Gene:	Rgs12 / 71729	MGIID:	1918979	Length:	1451	Species:	Mus musculus

Alignment Length:	183	Identity:	60/183 - (32%)
Similarity:	89/183 - (48%)	Gaps:	49/183 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 DLVNAEFLDGE--------------------QPTLEEIR--------SWGKSFDKLMKSTAGRKV 155
            ||.:|...|||                    .|:::..|        ||..||::|::...|.:.
Mouse   664 DLESATVSDGELTGADLKDCISNNSLSSNASLPSVQSCRRLRERRVASWAVSFERLLQDPVGVRY 728

  Fly   156 FQNFLRSEFSEENILFWLACEDL-------KKENSPELVEEKARLIYEDYISILSPREVSLDSRV 213
            |.:|||.||||||||||.|||..       |||     :..:||.|:..::...:...|::||:.
Mouse   729 FSDFLRKEFSEENILFWQACECFSHVPAHDKKE-----LSYRAREIFSKFLCSKATTPVNIDSQA 788

  Fly   214 R---EIVNRNMIEPTTHTFDEAQIQIYTLMHRDSYPRFLNSQKFK--TLAQLQ 261
            :   :|:|    .|....|.|.|:||:.||..|||.|||.||.::  .||:::
Mouse   789 QLADDILN----APHPDMFKEQQLQIFNLMKFDSYTRFLKSQLYQECVLAEVE 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhit	NP_611271.3	RGS_RZ-like	139..256	CDD:188673	49/128 (38%)
Rgs12	XP_006504183.1	PDZ_signaling	19..95	CDD:238492
		PTB_RGS12	227..358	CDD:269984
		RGS_RGS12	716..830	CDD:188696	47/122 (39%)
		RGS12_us1	836..949	CDD:374670	0/2 (0%)
		RBD1_RGS12	962..1031	CDD:340656
		Ubiquitin_like_fold	1032..1104	CDD:391949
		RGS12_us2	1106..1180	CDD:374668
		GoLoco	1189..1209	CDD:366965
		RGS12_usC	1238..1361	CDD:374669
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900