DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhit and Axin2

DIOPT Version :9

Sequence 1:	NP_611271.3	Gene:	Dhit / 37037	FlyBaseID:	FBgn0028743	Length:	274	Species:	Drosophila melanogaster
Sequence 2:	NP_056547.3	Gene:	Axin2 / 12006	MGIID:	1270862	Length:	840	Species:	Mus musculus

Alignment Length:	211	Identity:	49/211 - (23%)
Similarity:	82/211 - (38%)	Gaps:	60/211 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 GVSPTVGGSVGILGSTSNVLQESNATTFQ----RPQSQKPCCFCWCCCCSCSWAKCLAIKNADEN 113
            |.:|....|||.:.||..:...|||...:    .|:.:                       |..:
Mouse    31 GETPPCQPSVGKVQSTKPMPVSSNARRNEDGLGEPEGR-----------------------ASPD 72

  Fly   114 APTKRDLVNAEFLDGEQPTLEEIRSWGKSFDKLMKSTAGRKVFQNFLRSEFSEENILFWLACEDL 178
            :|..|                    |.||...|:....|..:|:.||..|...:.:.||.||...
Mouse    73 SPLTR--------------------WTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGF 117

  Fly   179 KKENSPELVEEK----ARLIYEDYI---SILSPR-EVSLDSRVREIVNRNMIEPTTHTFDEAQIQ 235
            ::.|   |.:.|    |:.||:.||   |::|.: :.:..:.:|:.:.:..|...  .||:||.:
Mouse   118 RQMN---LKDTKTLRVAKAIYKRYIENNSVVSKQLKPATKTYIRDGIKKQQIGSV--MFDQAQTE 177

  Fly   236 IYTLMHRDSYPRFLNS 251
            |..:|..::|..||.|
Mouse   178 IQAVMEENAYQVFLTS 193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhit	NP_611271.3	RGS_RZ-like	139..256	CDD:188673	35/121 (29%)
Axin2	NP_056547.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75		12/66 (18%)
		AXIN1_TNKS_BD	10..73	CDD:374700	12/64 (19%)
		Tankyrase-binding motif	21..30
		RGS_Axin	82..198	CDD:188662	32/117 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..363
		Interaction with GSK3B. /evidence=ECO:0000250	327..413
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..435
		Interaction with beta-catenin. /evidence=ECO:0000250	413..478
		Axin_b-cat_bind	432..467	CDD:370146
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..485
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	572..614
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..745
		DAX	758..840	CDD:197474
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810