DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhit and Rgs14

DIOPT Version :9

Sequence 1:	NP_611271.3	Gene:	Dhit / 37037	FlyBaseID:	FBgn0028743	Length:	274	Species:	Drosophila melanogaster
Sequence 2:	NP_446216.1	Gene:	Rgs14 / 114705	RGDID:	620003	Length:	544	Species:	Rattus norvegicus

Alignment Length:	161	Identity:	52/161 - (32%)
Similarity:	84/161 - (52%)	Gaps:	22/161 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 NAEFLDGEQPTLEEIRSWGKSFDKLMKSTAGRKVFQNFLRSEFSEENILFWLACE---DLKKENS 183
            ::.|...|||    :.||.:||::|::...|...|..||:.|||.||:.||.|||   .:...::
  Rat    51 SSPFSTDEQP----VASWAQSFERLLQDPRGLAYFTEFLKKEFSAENVTFWQACERFQQIPASDT 111

  Fly   184 PELVEEKARLIYEDYIS--ILSPREVSLDSRVREIVNRNMIEPTTHTFDEAQIQIYTLMHRDSYP 246
            .:|.:| |..||.:::|  .|||..:...:.:.|.|   :.:|....|...|:||:.||..|||.
  Rat   112 KQLAQE-AHNIYHEFLSSQALSPVNIDRQAWLSEEV---LAQPRPDMFRAQQLQIFNLMKFDSYA 172

  Fly   247 RFLNSQKFK--TLAQLQ-------DNSNAGS 268
            ||:.|..::  .||:.:       .:|:.||
  Rat   173 RFVKSPLYQECLLAEAEGRPLREPGSSHLGS 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhit	NP_611271.3	RGS_RZ-like	139..256	CDD:188673	42/123 (34%)
Rgs14	NP_446216.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..59		1/7 (14%)
		RGS_RGS14	58..186	CDD:188697	46/135 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..220		3/13 (23%)
		Necessary for interaction with RABGEF1. /evidence=ECO:0000250	297..424
		RGS12_RBD	301..374	CDD:176412
		UBQ	382..443	CDD:294102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..493
		GoLoco	497..519	CDD:214645
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810