DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhit and RGS14

DIOPT Version :9

Sequence 1:	NP_611271.3	Gene:	Dhit / 37037	FlyBaseID:	FBgn0028743	Length:	274	Species:	Drosophila melanogaster
Sequence 2:	XP_024310096.1	Gene:	RGS14 / 10636	HGNCID:	9996	Length:	593	Species:	Homo sapiens

Alignment Length:	162	Identity:	54/162 - (33%)
Similarity:	84/162 - (51%)	Gaps:	18/162 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 NAEFLDGEQPTLEEIRSWGKSFDKLMKSTAGRKVFQNFLRSEFSEENILFWLACE---DLKKENS 183
            ::.|...|||    :.||..||::|::...|...|..||:.|||.||:.||.|||   .:...::
Human    51 SSPFPTEEQP----VASWALSFERLLQDPLGLAYFTEFLKKEFSAENVTFWKACERFQQIPASDT 111

  Fly   184 PELVEEKARLIYEDYIS--ILSPREVSLDSRVREIVNRNMIEPTTHTFDEAQIQIYTLMHRDSYP 246
            .:|.:| ||.||::::|  .|||..:...:.:.|.|   :.||....|...|:||:.||..|||.
Human   112 QQLAQE-ARNIYQEFLSSQALSPVNIDRQAWLGEEV---LAEPRPDMFRAQQLQIFNLMKFDSYA 172

  Fly   247 RFLNSQKFK--TLAQLQD---NSNAGSKADSP 273
            ||:.|..::  .||:.:.   .....|:..||
Human   173 RFVKSPLYRECLLAEAEGRPLREPGSSRLGSP 204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhit	NP_611271.3	RGS_RZ-like	139..256	CDD:188673	44/123 (36%)
RGS14	XP_024310096.1	RGS_RGS14	58..186	CDD:188697	48/135 (36%)
		RGS12_us1	189..273	CDD:318754	3/16 (19%)
		RGS12_RBD	303..376	CDD:176412
		RBD	376..445	CDD:128731
		GoLoco	525..547	CDD:214645
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810