DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhit and RGS19

DIOPT Version :9

Sequence 1:	NP_611271.3	Gene:	Dhit / 37037	FlyBaseID:	FBgn0028743	Length:	274	Species:	Drosophila melanogaster
Sequence 2:	XP_011526786.1	Gene:	RGS19 / 10287	HGNCID:	13735	Length:	246	Species:	Homo sapiens

Alignment Length:	256	Identity:	122/256 - (47%)
Similarity:	155/256 - (60%)	Gaps:	52/256 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GGSLGGVSPTVGGSVGILGSTSNVLQE----------------------SNATTFQRPQSQKPCC 90
            |..||   |::||  |.....|::|.:                      |:.|......|:.|||
Human    10 GPHLG---PSLGG--GARSCCSSLLNDPGPPPSPAITGPEEADRPPSMSSHDTASPAAPSRNPCC 69

  Fly    91 FCWCCCCSCSWAKCLAIKNADENAPTKR-----------DLVNAEFLDGEQPTLEEIRSWGKSFD 144
            .||||||||||           |...:|           .|.:.|..  ..|:.||::||.:|||
Human    70 LCWCCCCSCSW-----------NQERRRAWQASRESKLQPLPSCEVC--ATPSPEEVQSWAQSFD 121

  Fly   145 KLMKSTAGRKVFQNFLRSEFSEENILFWLACEDLKKENSPELVEEKARLIYEDYISILSPREVSL 209
            |||.|.|||.||:.|||:|:||||:|||||||:||.|.:..:|:||||||||||:|||||:||||
Human   122 KLMHSPAGRSVFRAFLRTEYSEENMLFWLACEELKAEANQHVVDEKARLIYEDYVSILSPKEVSL 186

  Fly   210 DSRVREIVNRNMIEPTTHTFDEAQIQIYTLMHRDSYPRFLNSQKFKTLAQLQDNSNAGSKA 270
            ||||||.:|:.|.||:.||||:||:|||||||||||||||:|..::.|. ||..|.:.|:|
Human   187 DSRVREGINKKMQEPSAHTFDDAQLQIYTLMHRDSYPRFLSSPTYRALL-LQGPSQSSSEA 246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhit	NP_611271.3	RGS_RZ-like	139..256	CDD:188673	83/116 (72%)
RGS19	XP_011526786.1	RGS_RGS19	116..233	CDD:188699	83/116 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	183	1.000	Domainoid score	I3425
eggNOG	1	0.900	-	-		E1_KOG3589
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47786
OrthoDB	1	1.010	-	-		D1409647at2759
OrthoFinder	1	1.000	-	-		FOG0000119
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103880
Panther	1	1.100	-	-	LDO	PTHR10845
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1014
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.790