DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5033 and AT2G40360

DIOPT Version :9

Sequence 1:	NP_611270.1	Gene:	CG5033 / 37036	FlyBaseID:	FBgn0028744	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_181567.3	Gene:	AT2G40360 / 818629	AraportID:	AT2G40360	Length:	753	Species:	Arabidopsis thaliana

Alignment Length:	813	Identity:	320/813 - (39%)
Similarity:	468/813 - (57%)	Gaps:	92/813 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTKKLALKRRGKDSEPTNEVVASSEASENEEE----------EEDLLQAVKDPGEDST-DDEGID 54
            |||    :.:|.:.:...|..:.:.:.:::::          |||||||   .|.||. |.:.:.
plant     1 MTK----RSKGANEDKLIETKSKNVSGKSQKQKKPVEAESLKEEDLLQA---SGTDSDYDGDSLP 58

  Fly    55 QEYHSDSSEELQFESDEEGNYLGRKQSSSAEEDEESSDEED-NEEEESTDGEEVEDEE---KDSK 115
            ...:||..:....:|:::|.:.|     :.:.|.|.||::| .|.:.|.|.|:.:..|   .|:.
plant    59 GSLNSDDFDSDFSDSEDDGTHEG-----TEDGDVEFSDDDDVLEHDGSIDNEDDDGSEHVGSDNN 118

  Fly   116 SKQTDDKPSGSGAASKKALTAELPKRDSSKPEYQDSDTS-DEEDIRNTVGNIPMHWYDEYKHIGY 179
            .:...|:.|..|.|                  .::||:| ||...||||||:|:.||::.|||||
plant   119 EEHGSDEDSERGEA------------------VEESDSSEDEVPSRNTVGNVPLKWYEDEKHIGY 165

  Fly   180 DWDAKKIIKPPQGDQIDEFLRKIEDPDFWRTVKDPLTGQDVRLTDEDIALIKRIVSGRIPNKDHE 244
            |...|||.|..:.|::|.||..|:|...||.:.|....:||.||.|:..:::||:.|..|:.|.:
plant   166 DLTGKKITKKEKQDKLDSFLATIDDSKTWRKIYDEYNDEDVELTKEESKIVQRILKGEAPHADFD 230

  Fly   245 EYEPWIEWFTSEVEKMPIKNVPDHKRSFLPSVSEKKRVSRMVHALKMGWMKTTEEVEREKQAKRG 309
            .|.|::|||..:....|:.:.|:.||.|:||..|.|:|.::|.|::.||:|..:..|.
plant   231 PYAPYVEWFKHDDAIHPLSSAPEPKRRFIPSKWEAKKVVKIVRAIRKGWIKFDKPEEE------- 288

  Fly   310 PKFYMLWETDTSREHMRRIHDPVSAPKRDLPGHAESYNPPPEYLFDAKETKEWLKLKDEPHKRKL 374
            |..|:||..|::.:...:....:..||..||||.|||||..||: ..:|.|...:|..|..:.|
plant   289 PNVYLLWGDDSTSDQKSKHLTYIPPPKLKLPGHDESYNPSLEYI-PTEEEKASYELMFEEDRPK- 351

  Fly   375 HFMPQKFKSLREVPAYSRYLRERFLRCLDLYLCPRAKRVKLNIDAEYLIPKLPSPRDLQPFPTVE 439
             |:|.:|.|||.:|||...|:|.|.||||||||||.::.::|||.|.|.|||||.:||:|:|...
plant   352 -FIPTRFTSLRSIPAYENALKESFERCLDLYLCPRVRKKRINIDPESLKPKLPSRKDLRPYPNSC 415

  Fly   440 SMVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCIRTIETDEVVRCVAWCPNPKLSI 504
            .:.|:|||..|.|:|.:..||::.|||.|.:|::||:.||||::..:.||.:.||||.|..:|.:
plant   416 YLEYKGHTGAVTSISTDSSGEWIASGSTDGSVRMWEVETGRCLKVWQFDEAIMCVAWNPLSRLPV 480

  Fly   505 IAVATGNRLLLVNPKVGDKVLVKKTDDLLAEAPSQDVIESERIKTA------------VQWSNAE 557
            :|||.|..|..:|.::|       ||:       :..|..||:.:.            |.|.
plant   481 LAVAMGRDLFFLNTELG-------TDE-------EQEITKERLHSGNIPEPDASVAAIVTWL--- 528

  Fly   558 ADEQEKGVRVVITHFKPIRQVTWHGRGDYLATVMPEGANRSALIHQLSKRRSQ-IPFSKSKGLIQ 621
            .||...|::  |.|||.|..:.||.:||||:|||..|..|..::|||||:::| :|| |.:||..
plant   529 PDELYGGIK--IRHFKSISSIDWHRKGDYLSTVMASGETRGVVLHQLSKQKTQRLPF-KIRGLPV 590

  Fly   622 FVLFHPVKPCFFVATQHNIRIYDLVKQ-ELVKKLLTNSKWISGMSIHPKGDNLLVSTYDKKMLWF 685
            ..||||....|||||:.::|:|:|:|. |..|||.|..:.||.|:|||.||||:|.:.:.||.||
plant   591 CTLFHPSLSYFFVATRKDVRVYNLLKPGEATKKLETGLREISSMAIHPGGDNLIVGSKEGKMCWF 655

  Fly   686 DLDLSTKPYQTMRLHRNAVRSVAFHLRYPLFASGSDDQAVIVSHGMVYNDLLQNPLIVPLKKLQT 750
            |:|||:|||:|::.|...:.:||.|..||||||.|:|....|.||||||||.||||||||:.|:.
plant   656 DMDLSSKPYKTLKNHPKDITNVAVHRSYPLFASCSEDSTAYVFHGMVYNDLNQNPLIVPLEILRG 720

  Fly   751 HEKRDEFGVLDVNWHPVQPWVFSTGADSTIRLY 783
            |..:.  ||||..:||.|||:|:.||||.|:||
plant   721 HSSKG--GVLDCKFHPRQPWLFTAGADSIIKLY 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5033	NP_611270.1	BOP1NT	171..436	CDD:214986	109/264 (41%)
		WD40	436..>783	CDD:225201	160/360 (44%)
		WD40	442..783	CDD:238121	159/354 (45%)
		WD40 repeat	452..487	CDD:293791	15/34 (44%)
		WD40 repeat	492..570	CDD:293791	23/89 (26%)
		WD40 repeat	575..613	CDD:293791	18/38 (47%)
		WD40 repeat	621..655	CDD:293791	16/34 (47%)
		WD40 repeat	661..698	CDD:293791	23/36 (64%)
		WD40 repeat	704..752	CDD:293791	29/47 (62%)
		WD40 repeat	759..783	CDD:293791	14/23 (61%)
AT2G40360	NP_181567.3	BOP1NT	157..412	CDD:285371	109/264 (41%)
		WD40	415..751	CDD:295369	159/357 (45%)
		WD40	417..>751	CDD:225201	159/355 (45%)
		WD40 repeat	426..463	CDD:293791	16/36 (44%)
		WD40 repeat	468..509	CDD:293791	17/54 (31%)
		WD40 repeat	545..582	CDD:293791	17/36 (47%)
		WD40 repeat	589..625	CDD:293791	16/35 (46%)
		WD40 repeat	631..671	CDD:293791	23/39 (59%)
		WD40 repeat	674..698	CDD:293791	11/23 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	219	1.000	Domainoid score	I725
eggNOG	1	0.900	-	-		E1_KOG0650
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6612
Inparanoid	1	1.050	556	1.000	Inparanoid score	I251
OMA	1	1.010	-	-		QHG54153
OrthoDB	1	1.010	-	-		D759498at2759
OrthoFinder	1	1.000	-	-		FOG0004220
OrthoInspector	1	1.000	-	-		oto3485
orthoMCL	1	0.900	-	-		OOG6_102525
Panther	1	1.100	-	-	LDO	PTHR17605
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2967
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840