DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5033 and PAFAH1B1

DIOPT Version :9

Sequence 1:NP_611270.1 Gene:CG5033 / 37036 FlyBaseID:FBgn0028744 Length:784 Species:Drosophila melanogaster
Sequence 2:XP_011522203.1 Gene:PAFAH1B1 / 5048 HGNCID:8574 Length:428 Species:Homo sapiens


Alignment Length:588 Identity:128/588 - (21%)
Similarity:197/588 - (33%) Gaps:211/588 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   186 IIKPPQGDQIDEFLRKIEDPDFWRTVKDPLTGQDVRLTDEDIALIKRIVSGRIPNKDHEEYEPWI 250
            ::...|.|::|.|.|                |:|..|...|.|..:.|......|...|.|..  
Human     2 VLSQRQRDELDWFQR----------------GEDSILNKADEARNRAIADYLRSNGYEEAYSV-- 48

  Fly   251 EWFTSEVEKMPIKNVPDHKRSFLPSVSEKK-----RVSRMVHALKMGWMKTTEE------VEREK 304
              |..|.| :.:....|.|.:   .:.|||     |:.:.|..|:....:..||      :.:::
Human    49 --FKKEAE-LDVNEELDKKYA---GLLEKKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKR 107

  Fly   305 QAK----RGPKFYMLWETDTSREHMRR-IHDP-----VSAP---------------KRDLPGHAE 344
            ..|    |.|:.|.|   ...|..:.| |..|     |||.               :|.|.||.:
Human   108 DPKEWIPRPPEKYAL---SGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTD 169

  Fly   345 SYNPPPEYLFDAKETKEWLKLKDEPHKRKLHFMPQKFKSLREVPAYSRYLRERFLRCLDLYLCPR 409
            |..   :..||              |..||                             |..|..
Human   170 SVQ---DISFD--------------HSGKL-----------------------------LASCSA 188

  Fly   410 AKRVKLNIDAEYLIPKLPSPRDLQPFPTVESMVYRGHTDLVRSVSVEPKGEYLVSGSDDKTVKIW 474
            ...:||              .|.|.|..:.:|  .||...|.||::.|.|:::||.|.|||:|:|
Human   189 DMTIKL--------------WDFQGFECIRTM--HGHDHNVSSVAIMPNGDHIVSASRDKTIKMW 237

  Fly   475 EIATGRCIRTIETD-EVVRCVAWCPNPKLSIIAVATGNRLLLVNPKVGDKVLVKKTDDLLAEAPS 538
            |:.||.|::|.... |.||.|.  ||...::||..:.::.:        :|.|..|.:..||   
Human   238 EVQTGYCVKTFTGHREWVRMVR--PNQDGTLIASCSNDQTV--------RVWVVATKECKAE--- 289

  Fly   539 QDVIESERIKTAVQW---------SNAEADEQEKGVRVVITHFKPIRQVTWHGRGDYLATVMPEG 594
              :.|.|.:...:.|         |.|...|.:|.       .||         |.:|       
Human   290 --LREHEHVVECISWAPESSYSSISEATGSETKKS-------GKP---------GPFL------- 329

  Fly   595 ANRSALIHQLSKRRSQIPFSKSKGLIQFVLFHPVKPCFFVATQHNIRIYDLVKQELVKKLLTNSK 659
                     ||..|.:                            .|:::|:.....:..|:.:..
Human   330 ---------LSGSRDK----------------------------TIKMWDVSTGMCLMTLVGHDN 357

  Fly   660 WISGMSIHPKGDNLLVSTYDKKMLWFDLDLSTKPYQTMRLHRNAVRSVAFHLRYPLFASGSDDQA 724
            |:.|:..|..|..:|....||.:..:|.. :.:..:|:..|.:.|.|:.||...|...:||.||.
Human   358 WVRGVLFHSGGKFILSCADDKTLRVWDYK-NKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQT 421

  Fly   725 VIV 727
            |.|
Human   422 VKV 424

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5033NP_611270.1 BOP1NT 171..436 CDD:214986 55/285 (19%)
WD40 436..>783 CDD:225201 72/302 (24%)
WD40 442..783 CDD:238121 71/296 (24%)
WD40 repeat 452..487 CDD:293791 17/34 (50%)
WD40 repeat 492..570 CDD:293791 18/86 (21%)
WD40 repeat 575..613 CDD:293791 5/37 (14%)
WD40 repeat 621..655 CDD:293791 2/33 (6%)
WD40 repeat 661..698 CDD:293791 8/36 (22%)
WD40 repeat 704..752 CDD:293791 11/24 (46%)
WD40 repeat 759..783 CDD:293791
PAFAH1B1XP_011522203.1 LisH 30..53 CDD:285685 5/26 (19%)
WD40 115..>428 CDD:225201 100/451 (22%)
WD40 122..426 CDD:238121 97/444 (22%)
WD40 repeat 129..166 CDD:293791 8/36 (22%)
WD40 repeat 172..208 CDD:293791 13/97 (13%)
WD40 repeat 213..249 CDD:293791 18/35 (51%)
WD40 repeat 256..291 CDD:293791 11/49 (22%)
WD40 repeat 297..353 CDD:293791 14/115 (12%)
WD40 repeat 359..395 CDD:293791 8/36 (22%)
WD40 repeat 401..425 CDD:293791 11/24 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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