DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5033 and SPBC4F6.13c

DIOPT Version :9

Sequence 1:	NP_611270.1	Gene:	CG5033 / 37036	FlyBaseID:	FBgn0028744	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_596113.2	Gene:	SPBC4F6.13c / 2540888	PomBaseID:	SPBC4F6.13c	Length:	740	Species:	Schizosaccharomyces pombe

Alignment Length:	818	Identity:	297/818 - (36%)
Similarity:	442/818 - (54%)	Gaps:	116/818 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTKKLALKRRGKDSEPTNEVVASSEASENEEEEEDLLQAVKD-PGEDSTDDEGIDQEYHSDSSEE 64
            |.:|.:..:|           |:|.....:::|::..:.|.: |.|..|:....:..:..|..||
pombe     5 MNRKRSRSKR-----------ANSNVGVEKDKEKEKSKGVSNVPNEVETESSSHEPSFKKDVDEE 58

  Fly    65 L-----QFESDEEGNYLGRKQSSSAEEDEESSDEEDNEEEESTDGEEVEDEEKDSKSKQTDDKPS 124
            :     :...:|||.|......|:.|...:..::.|:|||    .||::
pombe    59 IPSLTAELSEEEEGEYSSESGRSTPELSPDDFEDADDEEE----FEEID---------------- 103

  Fly   125 GSGAASKKALTAELPKRDSSKPEYQDSDTSDEEDIRNTVGNIPMHWYDEYKHIGYDWDAKKIIKP 189
             :|.:|                   ||.|   ||:...:...|   |||..:|.||.|.|||.:|
pombe   104 -AGYSS-------------------DSST---EDVAPGLYESP---YDENLYINYDIDGKKITRP 142

  Fly   190 PQGDQIDEFLRKIEDPDFWRTVKDPLTGQDVRLTDEDIALIKRIVSGRIPNKDHEEYEPWIEWFT 254
            .....:|..:..|:....|..:.||:||:.|.||.|::.|:||:....||:::.:.|..:.::||
pombe   143 ATPAALDSLIASIDKDKGWTGIVDPMTGKPVNLTTEELGLLKRLAQSEIPDENFDPYPDYDDFFT 207

  Fly   255 SEVEKMPIKNVPDHKRSFLPSVSEKKRVSRMVHALKMGWMKTTEE-VEREKQAKRGPKFYMLWET 318
            :.|.:.|:.:.|:.||.|.||..|:||:.::.:|::.|.:.|:|: .|||::::.....:.||..
pombe   208 NTVRETPLSSAPEPKRRFAPSKHEQKRILQLAYAIRKGRILTSEQRAERERESQSNYADHDLWAD 272

  Fly   319 DTSREHMRRIHDPVSAPKRDLPGHAESYNPPPEYLFDAKETKEWLKLKDEPHKRKLHFMPQKFKS 383
            |......:|..|...|||...|.|.||||||.|||   |::.::               |:|:||
pombe   273 DDQATVNQRKLDYAPAPKLPPPSHEESYNPPEEYL---KQSSDF---------------PKKYKS 319

  Fly   384 LREVPAYSRYLRERFLRCLDLYLCPRAKRVKLNIDAEYLIPKLPSPRDLQPFPTVESMVYRGHTD 448
            ||.|||||..::|:|.|||||||.||.:|.|||||.|.|:||||:|.:|:||||..:.|:.||..
pombe   320 LRVVPAYSNLIKEKFERCLDLYLAPRVRRTKLNIDPESLLPKLPTPSELRPFPTRCTNVFIGHKG 384

  Fly   449 LVRSVSVEPKGEYLVSGSDDKTVKIWEIATGRCI-----------RTIETDE------------- 489
            .||.:||...|.:|.||.||..::|||:.||||:           ..|::||
pombe   385 RVRCLSVHVSGNWLASGGDDGVLRIWEVMTGRCVWKCSLDSFGNAHNIDSDEDAVNESLSHSTKS 449

  Fly   490 -VVRCVAWCPNPKLSIIAVATGNRLLLVNPKVGDKVLVKKTDDLLAEAPSQDVIESERIKTAVQW 553
             :::.:||.|.....::|||....:..:.|.:.....::.:.:|...||.|:       .:|:..
pombe   450 SIIQSLAWGPLSDSPVLAVAVDETVYFITPPIFSDEQIEASKELFTSAPYQE-------SSAIWR 507

  Fly   554 SNAEADEQEKG--VRVVITHFKPIRQVTWHGRGDYLATVMPEGANRSALIHQLSKRRSQIPFSKS 616
            ..|:...|..|  |...::....|:.::||.|||||||..|..::::.||||||:..||.|||||
pombe   508 RGAKQSLQLHGGIVHATVSTPSSIKSLSWHRRGDYLATSSPTSSSQAVLIHQLSRGASQSPFSKS 572

  Fly   617 KGLIQFVLFHPVKPCFFVATQHNIRIYDLVKQELVKKLLTNSKWISGMSIHPKGDNLLVSTYDKK 681
            ||.:|.|.|||..|...||||..:|||:||||||||.|||..||:|.:|:|..||::::.:|||:
pombe   573 KGSVQAVTFHPTMPYLLVATQRYVRIYNLVKQELVKTLLTGVKWVSSLSVHSSGDHVIIGSYDKR 637

  Fly   682 MLWFDLDLSTKPYQTMRLHRNAVRSVAFHLRYPLFASGSDDQAVIVSHGMVYNDLLQNPLIVPLK 746
            :.|||||.|:|||:.:|.|..|:|.|::|...|||.|||||..|.|.||.||:|||.||||||||
pombe   638 LCWFDLDFSSKPYKNLRYHSRALRDVSYHPSLPLFCSGSDDGDVQVFHGRVYSDLLANPLIVPLK 702

  Fly   747 KLQTHEKRDEFGVLDVNWHPVQPWVFSTGADSTIRLYT 784
            .|:.|:..|..|||...|||.:.|:||.||...||::|
pombe   703 ILRNHKVVDNVGVLSTCWHPKEAWLFSAGAGGEIRMWT 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5033	NP_611270.1	BOP1NT	171..436	CDD:214986	105/265 (40%)
		WD40	436..>783	CDD:225201	157/373 (42%)
		WD40	442..783	CDD:238121	155/367 (42%)
		WD40 repeat	452..487	CDD:293791	16/45 (36%)
		WD40 repeat	492..570	CDD:293791	16/79 (20%)
		WD40 repeat	575..613	CDD:293791	19/37 (51%)
		WD40 repeat	621..655	CDD:293791	21/33 (64%)
		WD40 repeat	661..698	CDD:293791	17/36 (47%)
		WD40 repeat	704..752	CDD:293791	29/47 (62%)
		WD40 repeat	759..783	CDD:293791	12/23 (52%)
SPBC4F6.13c	NP_596113.2	BOP1NT	124..372	CDD:214986	105/265 (40%)
		WD40	375..739	CDD:295369	155/370 (42%)
		WD40	376..739	CDD:225201	155/369 (42%)
		WD40 repeat	388..447	CDD:293791	18/58 (31%)
		WD40 repeat	453..516	CDD:293791	13/69 (19%)
		WD40 repeat	531..569	CDD:293791	19/37 (51%)
		WD40 repeat	577..611	CDD:293791	21/33 (64%)
		WD40 repeat	617..654	CDD:293791	17/36 (47%)
		WD40 repeat	660..708	CDD:293791	29/47 (62%)
		WD40 repeat	715..739	CDD:293791	12/23 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	228	1.000	Domainoid score	I515
eggNOG	1	0.900	-	-		E1_KOG0650
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6612
Inparanoid	1	1.050	516	1.000	Inparanoid score	I226
OMA	1	1.010	-	-		QHG54153
OrthoFinder	1	1.000	-	-		FOG0004220
OrthoInspector	1	1.000	-	-		oto101980
orthoMCL	1	0.900	-	-		OOG6_102525
Panther	1	1.100	-	-	LDO	PTHR17605
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R401
SonicParanoid	1	1.000	-	-		X2967
TreeFam	1	0.960	-	-
	14	13.860