DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5033 and BOP1

DIOPT Version :9

Sequence 1:	NP_611270.1	Gene:	CG5033 / 37036	FlyBaseID:	FBgn0028744	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_056016.1	Gene:	BOP1 / 23246	HGNCID:	15519	Length:	746	Species:	Homo sapiens

Alignment Length:	783	Identity:	375/783 - (47%)
Similarity:	519/783 - (66%)	Gaps:	61/783 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KRRGKDSEPTNEVVASSEASENEEEEEDLLQAVKDPGEDSTDDEGIDQEYHSDSSEELQFESDEE 72
            |||   |||         ..|.|.|.|..|.........:..|.|:     |||         ||
Human    19 KRR---SEP---------ELEPEPEPEPPLLCTSPLSHSTGSDSGV-----SDS---------EE 57

  Fly    73 GNYLGRKQSSSAEEDEESSDEEDNEEEESTDGEEVEDEEKDSKSKQTDDKPSGSGAASKKALTAE 137
            ..:.|.:.|.|     :||:::|..:||..|| .::||......|.|:::...|         ..
Human    58 SVFSGLEDSGS-----DSSEDDDEGDEEGEDG-ALDDEGHSGIKKTTEEQVQAS---------TP 107

  Fly   138 LPKRDSSKPEYQD---SDTSDEEDIRNTVGNIPMHWYDEYKHIGYDWDAKKIIKPPQ-GDQIDEF 198
            .|:.:.:.....|   .|:||||||||||||:|:.|||::.|:|||.|.::|.||.: .|::|:|
Human   108 CPRTEMASARIGDEYAEDSSDEEDIRNTVGNVPLEWYDDFPHVGYDLDGRRIYKPLRTRDELDQF 172

  Fly   199 LRKIEDPDFWRTVKDPLTGQDVRLTDEDIALIKRIVSGRIPNKDHEEYEPWIEWFTSEVEKMPIK 263
            |.|::|||:||||:||:||:|:|||||.:||::|:.||:..:.....|||.:::|:.:|...|:.
Human   173 LDKMDDPDYWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNPYEPAVDFFSGDVMIHPVT 237

  Fly   264 NVPDHKRSFLPSVSEKKRVSRMVHALKMGWMKTTEEVEREKQAKRGPKFYMLWETDTSREHMRRI 328
            |.|..||||:||:.||::|||||||:||||      ::..:.....|.||.||..:.....:.|.
Human   238 NRPADKRSFIPSLVEKEKVSRMVHAIKMGW------IQPRRPRDPTPSFYDLWAQEDPNAVLGRH 296

  Fly   329 HDPVSAPKRDLPGHAESYNPPPEYLFDAKETKEWLKLKDEPHKRKLHFMPQKFKSLREVPAYSRY 393
            ...|.|||..|||||||||||||||...:|...|  .:.||.:|||.|:|:||.|||.||||.|:
Human   297 KMHVPAPKLALPGHAESYNPPPEYLLSEEERLAW--EQQEPGERKLSFLPRKFPSLRAVPAYGRF 359

  Fly   394 LRERFLRCLDLYLCPRAKRVKLNIDAEYLIPKLPSPRDLQPFPTVESMVYRGHTDLVRSVSVEPK 458
            ::|||.||||||||||.:::::|:|.|.||||||.|||||||||.:::|||||:||||.:||.|.
Human   360 IQERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQPFPTCQALVYRGHSDLVRCLSVSPG 424

  Fly   459 GEYLVSGSDDKTVKIWEIATGRCIRTIETDEVVRCVAWCPNPKLSIIAVATGNRLLLVNPKVGDK 523
            |::|||||||.::::||:||.||:||:....||:.|||.|:|.:.::|.|..:.:||:||.:||:
Human   425 GQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVCLVAAAVEDSVLLLNPALGDR 489

  Fly   524 VLVKKTDDLLAE--APSQDVIESERIKTAVQWSNAEADEQEKGVRVVITHFKPIRQVTWHGRGDY 586
            ::...||.||:.  .|.:..::..|      |..|..:|::.|:|:.|.|.||:.||||||||||
Human   490 LVAGSTDQLLSAFVPPEEPPLQPAR------WLEASEEERQVGLRLRICHGKPVTQVTWHGRGDY 548

  Fly   587 LATVMPEGANRSALIHQLSKRRSQIPFSKSKGLIQFVLFHPVKPCFFVATQHNIRIYDLVKQELV 651
            ||.|:....:...||||||:||||.||.:|.|.:|.|.|||.:|...||:|.::|:|.|::|||.
Human   549 LAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQRSVRLYHLLRQELT 613

  Fly   652 KKLLTNSKWISGMSIHPKGDNLLVSTYDKKMLWFDLDLSTKPYQTMRLHRNAVRSVAFHLRYPLF 716
            |||:.|.||:|.:::||.|||::..:||.|::|||||||||||:.:|.|:.|:|:||||.|||||
Human   614 KKLMPNCKWVSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLRHHKKALRAVAFHPRYPLF 678

  Fly   717 ASGSDDQAVIVSHGMVYNDLLQNPLIVPLKKLQTHEKRDEFGVLDVNWHPVQPWVFSTGADSTIR 781
            ||||||.:|||.|||||||||||||:||:|.|:.|....:.|||||.:||.||||||:|||.|:|
Human   679 ASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLGVLDVIFHPTQPWVFSSGADGTVR 743

  Fly   782 LYT 784
            |:|
Human   744 LFT 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5033	NP_611270.1	BOP1NT	171..436	CDD:214986	136/265 (51%)
		WD40	436..>783	CDD:225201	186/348 (53%)
		WD40	442..783	CDD:238121	184/342 (54%)
		WD40 repeat	452..487	CDD:293791	19/34 (56%)
		WD40 repeat	492..570	CDD:293791	24/79 (30%)
		WD40 repeat	575..613	CDD:293791	23/37 (62%)
		WD40 repeat	621..655	CDD:293791	17/33 (52%)
		WD40 repeat	661..698	CDD:293791	20/36 (56%)
		WD40 repeat	704..752	CDD:293791	36/47 (77%)
		WD40 repeat	759..783	CDD:293791	17/23 (74%)
BOP1	NP_056016.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..116		34/137 (25%)
		BOP1NT	144..402	CDD:285371	136/265 (51%)
		Sufficient for nucleolar localization. /evidence=ECO:0000250	265..427		91/169 (54%)
		WD40	408..745	CDD:295369	184/342 (54%)
		WD40	409..>745	CDD:225201	183/341 (54%)
		WD 1	411..450		23/38 (61%)
		WD40 repeat	417..453	CDD:293791	20/35 (57%)
		WD 2	452..492		15/39 (38%)
		WD40 repeat	457..556	CDD:293791	42/104 (40%)
		WD 3	532..576		27/43 (63%)
		WD 4	577..615		17/37 (46%)
		WD40 repeat	583..613	CDD:293791	14/29 (48%)
		WD 5	618..657		22/38 (58%)
		WD40 repeat	623..660	CDD:293791	20/36 (56%)
		WD 6	661..700		29/38 (76%)
		WD40 repeat	666..711	CDD:293791	35/44 (80%)
		WD 7	716..746		19/29 (66%)
		WD40 repeat	721..745	CDD:293791	17/23 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146978
Domainoid	1	1.000	291	1.000	Domainoid score	I1546
eggNOG	1	0.900	-	-		E1_KOG0650
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6612
Inparanoid	1	1.050	741	1.000	Inparanoid score	I591
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54153
OrthoDB	1	1.010	-	-		D261614at33208
OrthoFinder	1	1.000	-	-		FOG0004220
OrthoInspector	1	1.000	-	-		oto91424
orthoMCL	1	0.900	-	-		OOG6_102525
Panther	1	1.100	-	-	LDO	PTHR17605
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2967
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.810