Protein Alignment CG5033 and BOP1

DIOPT Version :10

• Sequence 1: NP_611270.1
• Gene: CG5033 / 37036
• FlyBaseID: FBgn0028744
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_056016.1
• Gene: BOP1 / 23246
• HGNCID: 15519
• Length: 746
• Species: Homo sapiens
• Alignment Length: 809
• Identity: 138/809 - (17%)
• Similarity: 242/809 - (29%)
• Gaps: 307/809 - (37%)

  Fly   188 LFATDVLAREQISTTADQTSALEEADDSFLYYTPQQGNVLFGSALDGWAFDLATFARLY------ 246
            |:.|..:....:..|:.|.|.|          |.|:.|....:|        ||:|..|
Human   100 LYRTGSVGIGNLQRTSSQRSTL----------TYQRNNYALNTA--------ATYAEPYRPVQYR 146

  Fly   247 -----HGKLE--GVQDSGELLNALWGDYFYSPRKKA-------------------IEPGATEKGR 285
                 :.:|:  |..|.|...:.........||:.|                   ::..|....:
Human   147 VQECSYNRLQHTGPADDGATRSPSIDSIQKDPREFAWRDPELPEVIHMLQHQFPSVQANAAAYLQ 211

  Fly   286 KPLF----VQLVLDNLWNIYGLVENRDEAKLRTISERCGVVQNVRDLKHAD-GRVPVRNLLAGWL 345
            ...|    |::.:..|..|..||:..|...|......||.::|:...|..| .::.::|:  |.:
Human   212 HLCFGDNKVKMEVYRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNV--GGI 274

  Fly   346 PMERSLLGAVCRTVPNPTGISEMKAEKLLCSRLADFASYPAETQALKRDIM-------------- 396
            |   :||..:.:::       :.:..:|:...|.:.:|..|....:.||.:
Human   275 P---ALLRLLRKSI-------DAEVRELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGW 329

  Fly   397 -RCRADSERLIVFVSKMFPIEHGALAGAKDTLERLTKALSLSDPEDGGCDGEAEIFLAFARVYSG 460
             ....|.:..|.|.:.:      .|......|..|:.|...:..:...|:|..:
Human   330 NNSSFDDDHKIKFQTSL------VLRNTTGCLRNLSSAGEEARKQMRSCEGLVD----------- 377

  Fly   461 TLRRGSRVFVIGPKYDPRTMITTDDAGAN------------PHLVEIEIDSLFL--------LMG 505
                 |.::||      .|.:.|.|..:.            .:.:|:|:....|        |:|
Human   378 -----SLLYVI------HTCVNTSDYDSKTVENCVCTLRNLSYRLELEVPQARLLGLNELDDLLG 431

  Fly   506 RQLEPVDAVPA---------------------GNIVGI--------------------------- 522
            ::....|:.|:                     |.|.|:
Human   432 KESPSKDSEPSCWGKKKKKKKRTPQEDQWDGVGPIPGLSKSPKGVEMLWHPSVVKPYLTLLAESS 496

  Fly   523 ---------GGLQNV--------VLKTATLSNTRYCPPFVDL---------PLIATPILRVAVEP 561
                     |.|||:        ....|.:...:..|..|:|         ..:||.:..:|::.
Human   497 NPATLEGSAGSLQNLSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDV 561

  Fly   562 KDIQ-----KMPQLVRGL--------------------------KLLNQADACVE---------- 585
            ::.:     .|..||..|                          |.:..|.|..:
Human   562 RNKELIGKYAMRDLVNRLPGGNGPSILSDETVAAICCALHEVTSKNMENAKALADSGGIEKLVNI 626

  Fly   586 ---------VRVQESGEHVLLTLGEVHLERCIKDLQETYAKIELNVSKPIVPFKETIVPFVPTSE 641
                     ::|.::...||.||.:      .:||:..|.|...|.:..|.|        |.|.|
Human   627 TKGRGDRSSLKVVKAAAQVLNTLWQ------YRDLRSIYKKDGWNQNHFITP--------VSTLE 677

  Fly   642 DNPEEEIAKDREKDKTVTLQTPNRQCTIKLIAMPLSQEVVD------LLNRNEPVLKAYIKAHEA 700
                    :||.|... :|.|.|:|.:      |:.|.|..      ||...||     ...::.
Human   678 --------RDRFKSHP-SLSTTNQQMS------PIIQSVGSTSSSPALLGIREP-----RSEYDR 722

  Fly   701 KQPLPQALQDSISELRAGLTQLLPETVPFDRIWSFGPKKCGTNLLVNGTDFKHTAVWYENETTEQ 765
            .||..|...........||.....:..|. .|.|:.......|     ...:|..::|::::|.:
Human   723 TQPPMQYYNSQGDTTHKGLYPGSSKPSPI-YISSYSSPAREQN-----RRLQHQQLYYQDDSTRK 781

  Fly   766 TADDPRAQYESSFLNGFQMASLAGPLCDE 794
            |.|..|...:|.       .|...|.||:
Human   782 TLDAYRLYLQSP-------RSYEDPYCDD 803

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5033	NP_611270.1	BOP1NT	171..436	CDD:214986	53/299 (18%)
		WD40	442..783	CDD:238121	81/490 (17%)
		WD40 repeat	452..487	CDD:293791	6/34 (18%)
		WD40 repeat	492..570	CDD:293791	22/164 (13%)
		WD40 repeat	575..613	CDD:293791	10/56 (18%)
		WD40 repeat	621..655	CDD:293791	8/33 (24%)
		WD40 repeat	661..698	CDD:293791	10/42 (24%)
		WD40 repeat	704..752	CDD:293791	7/47 (15%)
		WD40 repeat	759..783	CDD:293791	5/23 (22%)
BOP1	NP_056016.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..116		3/15 (20%)
		BOP1NT	144..402	CDD:462371	47/297 (16%)
		Sufficient for nucleolar localization. /evidence=ECO:0000250	265..427		29/201 (14%)
		WD40	<408..744	CDD:441893	62/369 (17%)
		WD 1	411..450		7/38 (18%)
		WD40 repeat	417..453	CDD:293791	5/35 (14%)
		WD 2	452..492		3/39 (8%)
		WD40 repeat	457..556	CDD:293791	13/98 (13%)
		WD 3	532..576		7/43 (16%)
		WD 4	577..615		4/37 (11%)
		WD40 repeat	583..613	CDD:293791	2/29 (7%)
		WD 5	618..657		7/44 (16%)
		WD40 repeat	623..660	CDD:293791	7/42 (17%)
		WD 6	661..700		15/61 (25%)
		WD40 repeat	666..711	CDD:293791	15/67 (22%)
		WD 7	716..746		6/34 (18%)
		WD40 repeat	721..745	CDD:293791	5/23 (22%)