Protein Alignment aft and CMTR2

DIOPT Version :9

• Sequence 1: NP_477413.1
• Gene: aft / 37034
• FlyBaseID: FBgn0026309
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001093112.1
• Gene: CMTR2 / 55783
• HGNCID: 25635
• Length: 770
• Species: Homo sapiens
• Alignment Length: 709
• Identity: 227/709 - (32%)
• Similarity: 332/709 - (46%)
• Gaps: 123/709 - (17%)

  Fly    23 SEVEQLFEKKFHYQKPKGNKSWQLPPPDQALFSEFYQFEALQGLREQLNAVKSKLNDYGVQEWSA 87
            :::.:||.|.|.|.||..|: ||||.|.:....:..:..|...|:..||.||:.|:|..:.||..
Human    24 ADIFELFAKNFSYGKPLNNE-WQLPDPSEIFTCDHTELNAFLDLKNSLNEVKNLLSDKKLDEWHE 87

  Fly    88 HTNRRDPSGEVSWRLKNDTKAEFVTVAWCKLFECLHRYPLVTKPA-----VNSMHLCEAPGAFIA 147
            ||...:.:|::...::....||..|.||||..|.|..:||:.:.|     :||:|||||||||||
Human    88 HTAFTNKAGKIISHVRKSVNAELCTQAWCKFHEILCSFPLIPQEAFQNGKLNSLHLCEAPGAFIA 152

  Fly   148 SLNHYLHSKYEKDEIKWRWRSTTLNPYYEGNAINQMISDDRFIVHTLDNWFFHKDLTGNLLDVAN 212
            ||||||  |..:....|.|.:.|||||:|.|....||.|||.|.:||..|:|..|.||:::.:..
Human   153 SLNHYL--KSHRFPCHWSWVANTLNPYHEANDDLMMIMDDRLIANTLHWWYFGPDNTGDIMTLKF 215

  Fly   213 IDHLVERCEVEFQGQVDLVTADGSIDCAAQPDCQEEIVVRLFFAEVLSALRILSSGGNFLVKMFT 277
            :..|  :..:.....|.|||||||.||...|..||.:|..|.:.||::||..|.:||:|::||||
Human   216 LTGL--QNFISSMATVHLVTADGSFDCQGNPGEQEALVSSLHYCEVVTALTTLGNGGSFVLKMFT 278

  Fly   278 LFEACSVSLLYTLNCIFEEVHIFKPATSKRGNSEVYVICLNY---NKDHPDLPRLL----EEIKS 335
            :||.||::|:|.|||.|::||:|||||||.|||||||:||:|   ...||.|.::.    .|:|.
Human   279 MFEHCSINLMYLLNCCFDQVHVFKPATSKAGNSEVYVVCLHYKGREAIHPLLSKMTLNFGTEMKR 343

  Fly   336 KLAQPNDTLVMPLFAKFQIPHDFLMQHEIACRMYMKLQTDAIEGSIYAYESNDRHYLRHLHHLRS 400
            |          .||....||..||.:||..|..:.|.|.:.|..:|..:|...:.....|::||.
Human   344 K----------ALFPHHVIPDSFLKRHEECCVFFHKYQLETISENIRLFECMGKAEQEKLNNLRD 398

  Fly   401 LVANTYYSLYKVKPLEDSLCIVDKEA-----TSKALGFQVPVYGGSYTER---ESLKHGDLLKQI 457
            .....:...:::|.|..:..:|.|.:     .:|..| |...|..:|.||   |:|...|.:.:.
Human   399 CAIQYFMQKFQLKHLSRNNWLVKKSSIGCSTNTKWFG-QRNKYFKTYNERKMLEALSWKDKVAKG 462

  Fly   458 YCLRREFNQLEKCLNNRTP-YSYVKNRTAPLNL-----HISRGAPVQSLQSSMFASEPIL----- 511
            |     ||...:......| .|.:...||. ||     ||..|..:..::.|.|.:..||
Human   463 Y-----FNSWAEEHGVYHPGQSSILEGTAS-NLECHLWHILEGKKLPKVKCSPFCNGEILKTLNE 521

  Fly   512 ILRLRILDTFELD----PVWQSAPKCQLESKTL-------------------------CYLP--- 544
            .:...:...|.||    |..|.:..|.:.|:.|                         |.|.
Human   522 AIEKSLGGAFNLDSKFRPKQQYSCSCHVFSEELIFSELCSLTECLQDEQVVVPSNQIKCLLVGFS 586

  Fly   545 ---------PTEDEAFHTAQ----------------QRFFID-LLEEVKKLKP-DSIVFHKFLFL 582
                     |.|.....:|:                ||.|:| ||..:::|.. |.::.......
Human   587 TLRNIKMHIPLEVRLLESAELTTFSCSLLHDGDPTYQRLFLDCLLHSLRELHTGDVMILPVLSCF 651

  Fly   583 THYAASLLLFLIESVYQ----DCCFNSNQAQT---LTLSKLKDTANSA---LEQVLELL 631
            |.:.|. |:|::.|.::    .|..:|:..:|   |.....:|..|..   |:.|.|||
Human   652 TRFMAG-LIFVLHSCFRFITFVCPTSSDPLRTCAVLLCVGYQDLPNPVFRYLQSVNELL 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aft	NP_477413.1	FtsJ	110..319	CDD:279986	108/213 (51%)
CMTR2	NP_001093112.1	FtsJ	114..320	CDD:279986	107/209 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158091
Domainoid	1	1.000	213	1.000	Domainoid score	I2770
eggNOG	1	0.900	-	-		E1_KOG3674
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	294	1.000	Inparanoid score	I2774
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1327262at2759
OrthoFinder	1	1.000	-	-		FOG0007380
OrthoInspector	1	1.000	-	-		oto88571
orthoMCL	1	0.900	-	-		OOG6_105981
Panther	1	1.100	-	-	LDO	PTHR16121
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5504
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760