DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fab1 and MSS4

DIOPT Version :9

Sequence 1:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	NP_010494.1	Gene:	MSS4 / 851789	SGDID:	S000002616	Length:	779	Species:	Saccharomyces cerevisiae

Alignment Length:	805	Identity:	155/805 - (19%)
Similarity:	274/805 - (34%)	Gaps:	265/805 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1179 TEEENSPLVQHLKTMLTHDQFIFKQKIEIV----------HTLLTD-NRATAYDTSDALAMARRA 1232
            ||:|.|         |.|...|.:.:...|          |.:..| |..|:|.:|        :
Yeast    24 TEQEPS---------LLHSAIIERHQDRSVPNSNSNPDSNHRIKKDRNNHTSYHSS--------S 71

  Fly  1233 LAESIELWGPRLQEIEKLTAKQAHHIDSGTICTEELRPEQVQTADSSKVTTSSLPKENDPL-ECP 1296
            .:|| .:..|||.:.|..|...          .|||.|    |.::|::...:.....||| :..
Yeast    72 NSES-NMESPRLSDGESSTPTS----------IEELNP----TINNSRLVKRNYSISIDPLHDNS 121

  Fly  1297 SEDTETGASNSQTVLDKNFSIDQMLASTVN------VYSDKKSIRKILTQLLPSGNQVNPLQSPF 1355
            :.:|:....|:.|....|        ||.|      .:.:.|..:||.|..|.|.|.::...|..
Yeast   122 NNNTDDDHPNTITSPRPN--------STSNKEMQKYSFPEGKESKKITTPSLNSNNCLDLDNSSL 178

  Fly  1356 P---------AQDHLTLPLGSIPIHVRETDLSSVIAYSLTSMDYQKAIDEAEANSNAAHSSPQLK 1411
            .         ..||:.|   :..:..|.:.:|:|.|.| |::..::...::...:...|:|.. .
Yeast   179 VHTDSYIQDLNDDHILL---NKRVSRRSSRISAVTATS-TTIKQRRNTQDSNLPNIPFHASKH-S 238

  Fly  1412 RKIPLAESVSDAEDSPSLSRTSSNTSAAPNAS--------------VPSPATAASESEEKSKERI 1462
            :.:|:       :||..:...:.:||..||::              :|.|:..:.:....||...
Yeast   239 QILPM-------DDSDVIKLANGDTSMKPNSATKISHSMTSLPLHPLPQPSQKSKQYHMISKSTT 296

  Fly  1463 KQPPSPHITLAFQDHSCQFQ------------------CKIYFAREFDAMRSKSLKPPKLDKSLY 1509
            ..||.       .||..|..                  .....|.......|.:.:..|:.:||.
Yeast   297 SLPPE-------NDHYYQHSRGTNHNHAANAAAVNNNTTTTTAATGLKRSESATAEIKKMRQSLL 354

  Fly  1510 RRLEKSKMREELRISQSR---------------------TGSEMELVRKPSDVGAPRTTED---- 1549
            .:.|..:.|:...:...|                     ||..: .|.:.|.:..|.|..|
Yeast   355 HKREMKRKRKTFLVDDDRVLIGNKVSEGHVNFIIAYNMLTGIRV-AVSRCSGIMKPLTPADFRFT 418

  Fly  1550 -----DSNQEE---DARIALA-RSLCKSVQWEARG-------------------------GKSGS 1580
                 |.:..|   .::.|.. :..|..|..|.|.                         |||||
Yeast   419 KKLAFDYHGNELTPSSQYAFKFKDYCPEVFRELRALFGLDPADYLVSLTSKYILSELNSPGKSGS 483

  Fly  1581 RFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLLAKIFGVFRVS--VKKKDSF 1643
            .|..:.|.::::|.::..:.........:|:.::    :....||:.:.:|:.||.  :..::..
Yeast   484 FFYYSRDYKYIIKTIHHSEHIHLRKHIQEYYNHV----RDNPNTLICQFYGLHRVKMPISFQNKI 544

  Fly  1644 VERSV--MVMENLF-YGCNIENKFDLKGSERNRLVDPSNQQGEIVLLDEN----LVQMSWSK--- 1698
            ..|.:  :||.||| ...:|...:|||||...|.   :|...|.:..|.:    :..::|.:
Yeast   545 KHRKIYFLVMNNLFPPHLDIHITYDLKGSTWGRF---TNLDKERLAKDRSYRPVMKDLNWLEEGQ 606

  Fly  1699 -----PLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGLDKKN------------------- 1739
                 ||    ..||.|.. :::|...|.|...||||||:|:...|
Yeast   607 KIKFGPL----KKKTFLTQ-LKKDVELLAKLNTMDYSLLIGIHDINKAKEDDLQLADTASIEEQP 666

  Fly  1740 ----------GVLV--------------------------LGIIDYIRTFTLDKRVESIIKGSGI 1768
                      |.:|                          :||||::..:::.|::|:..:.
Yeast   667 QTQGPIRTGTGTVVRHFFREFEGGIRASDQFNNDVDLIYYVGIIDFLTNYSVMKKLETFWRS--- 728

  Fly  1769 LGGKGKDPTVVNPERYKQRFIDAMD 1793
            |....|..:.:.|..|..||.:.::
Yeast   729 LRHDTKLVSAIPPRDYANRFYEFIE 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264
		DEP	329..397	CDD:214489
		Fab1_TCP	464..717	CDD:239450
		PIPKc	1413..1797	CDD:295374	99/544 (18%)
MSS4	NP_010494.1	MSS4	4..772	CDD:227578	155/805 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810