Protein Alignment fab1 and FAB1

DIOPT Version :9

• Sequence 1: NP_611269.1
• Gene: fab1 / 37033
• FlyBaseID: FBgn0028741
• Length: 1809
• Species: Drosophila melanogaster
• Sequence 2: NP_116674.2
• Gene: FAB1 / 850574
• SGDID: S000001915
• Length: 2278
• Species: Saccharomyces cerevisiae
• Alignment Length: 2446
• Identity: 533/2446 - (21%)
• Similarity: 867/2446 - (35%)
• Gaps: 869/2446 - (35%)

  Fly    50 SYNTVNDISSGSSSSSSTQPVQV-------VGKSQFFSDSQTSTAEIADVET----SSQSSVRPQ 103
            |:...:.:.|.|:.:||...:..       :.|......|.::|:...|:.|    |:.|..:..
Yeast    11 SFPDGSHVRSSSTGTSSVNTIDATLSRPNYIKKPSLHIMSTSTTSTTTDLVTNPILSNISVPKIS 75

  Fly   104 PPTTLSIRT---NSETRGTSTSSNTAAE-DSETSDRVETLPLPTSEANQGRTVSNVLKHI----- 159
            |||:.||.|   .|...||::.||..|. ::.||...:.||..||    ||..|:.:|..
Yeast    76 PPTSSSIATATSTSHVTGTASHSNIKANANTSTSVNKKNLPPTTS----GRIPSSTIKRYPSRYK 136

  Fly   160 -----------------SNIVATKNN---NDLRNYKDTELQ------------------------ 180
                             |:|.|:|:.   ..:||.:...:|
Yeast   137 PSHSLQLPIKNDSNFKRSSIYASKSTVTAIPIRNNRPISMQNSYARTPDSDHDDVGDEVSSIKSA 201

  Fly   181 ---------------------------------RFWMPDSKAKECYDCSQKFSTFRRKHHCRLCG 212
                                             .:||.|..:|||:.|.:.|:|||||||||:||
Yeast   202 SSSLTASLSKSFLFAFYNNRKKDKTSNNGVLSKEYWMKDESSKECFSCGKTFNTFRRKHHCRICG 266

  Fly   213 QIFCSKCCNQVVPGMIIRCDGDLKVCNYCSKIVLTFLKSSSSEMGQDMQ---------------- 261
            |||||. |..::.|....|...::||..|.:...|:..||..|....||
Yeast   267 QIFCSS-CTLLIDGDRFGCHAKMRVCYNCYEHADTYEDSSDEENDSTMQLNEPRSRSRSRSSNTN 330

  Fly   262 ---ELQQHLSNKLEVQDSGSSL------AKHPQMQR--------------------------APL 291
               ....||....:...:|:.|      ..:||.|.                          .|.
Yeast   331 PYSHSHSHLHLISQDNHNGTDLHDPVAATDNPQQQNEVYLLNDDDVQSIMTSGEDSKLFISTPPP 395

  Fly   292 PRKTSV---------------------GYQEERFSSH------PT-YTTLSIDDRKNILQQSNSL 328
            |.|.::                     .||::....|      || ||...:|:..:....|||.
Yeast   396 PPKMAIPATKQGGSLEISFDSENDRALHYQDDNPGRHHHLDSVPTRYTIRDMDNISHYDTNSNST 460

  Fly   329 ITLHEEMQRDL---------------------------PAQNCGQRLIEFLNSN--NKSANEVQA 364
            :..|.......                           ||.:..:.:..:::||  ||.:|...|
Yeast   461 LRPHYNTNNSTITINNLNNTTSNNSNYNNTNSNSNINNPAHSLRRSIFHYVSSNSVNKDSNNSSA 525

  Fly   365 VAILNAMLAAGFLEP---IVPD----------------PEQMDFDSS------------------ 392
            ....:|. ::..|:|   |:.:                |.|.:..::
Yeast   526 TPASSAQ-SSSILDPANRIIGNYAHRNYKFKFNYNSKGPSQQNDTANGNNDNNNNNNNNNNNNNN 589

  Fly   393 ----------------------------------------LHYKFSKSSSSDTSRTMSPQFEAN- 416
                                                    |.|..::..||:...:||.....|
Yeast   590 NSASGIADNNNIPSNDNGTTFTLDKKKRNPLTKSKSTSAYLEYPLNEEDSSEDEGSMSIYSVLND 654

  Fly   417 PHAEPQPPKSMDQSA-----------------EEKEKELENELEN-------------------- 444
            .|....|.:||..|.                 :.|.|...|..::
Yeast   655 DHKTDNPIRSMRNSTKSFQRAQASLQRMRFRRKSKSKHFPNNSKSSIYRDLNFLTNSTPNLLSVV 719

  Fly   445 -------------DRCYTTATSKL----------------------------LASYCE------- 461
                         |:..::|.|:|                            :||...
Yeast   720 SDDNLYDDSSPLQDKASSSAASRLTDRKFSNSSGSNNNSNSNSNINTDPWKRIASISGFKLKKEK 784

  Fly   462 ----------HEEQLLAQMLRAHNLD--QEW----DKVLQMLCSTAANHFKPEHCSNDL--MDIR 508
                      |...||.|:|....:.  |||    |..|:.:..|..|       :.||  :|.|
Yeast   785 KRELNEVSLLHMHALLKQLLNDQEISNLQEWITLLDGALRKVLRTILN-------ARDLNTLDFR 842

  Fly   509 -NYVNFKKVPGGRRKDSKIVHGVAFSKNVAHKDMATHVPFPRILLLQCPIVYERIEGKFVTIETV 572
             .||..|::.||..::|:.:.||.|||.:..|.|..|:..|||||:..|:.|::....|::||:|
Yeast   843 QTYVKIKRISGGSPQNSEYIDGVVFSKALPSKTMPRHLKNPRILLIMFPLEYQKNNNHFLSIESV 907

  Fly   573 LLQEKEYLRNVCARIMSFKPNVVLVHKNVAGIAQDLLRSYEVTLVLDVKLSVMERLSRTLQCDIV 637
            ..||:|||..:.:|:.|..|:::.|..||:|.|.:||....:.:..::|..|:||:::..:.||.
Yeast   908 FRQEREYLDKLVSRLKSLHPDIIYVGANVSGYALELLNDSGIVVQFNMKPQVIERIAKLTEADIA 972

  Fly   638 SSIESNITMPKLGYCNDFYIRNY----NGKTLMFFEKLTNPRGYTCLLRGGSNAELTRVKRVASA 698
            .|::...|..|:|.|..|.:::|    ..||..|........|.|.||||.|...|.::|:|:..
Yeast   973 ISVDKLATNIKMGECETFEVKSYIYGNISKTYTFLRGCNPELGGTILLRGDSLENLRKIKQVSEF 1037

  Fly   699 LLFARYNWRLEMSFLLNEFAQPLSPKPSIFDSKETSPKTETEAELRSKRPIILERKSEDKITTIV 763
            :::|.::.:||.||..:.|.|                 ..|:..|         :::|.|...:.
Yeast  1038 MVYAIFSLKLESSFFNDNFIQ-----------------LSTDVYL---------KRAESKKLQVF 1076

  Fly   764 SENVSDFTDPLRASQAEALSTSPCAPPVVEALAVEPRYDNRFRTALSSTLLSVSPFLTFPLPY-L 827
            ....:||.                           .:::||        :|:|||.:.||:|: |
Yeast  1077 EGYFADFL---------------------------IKFNNR--------ILTVSPTVDFPIPFLL 1106

  Fly   828 ETEQGRKCKLRKLFPAELYFSKQWSRTGLERPDSMGDGEAGKSEPG-NKENQMQLLPAHDFVLMK 891
            |..:|.:.||                  :||.:..      :||.. :::.|:.:|...:..:.|
Yeast  1107 EKARGLEKKL------------------IERINQY------ESESDLDRQTQLNMLQGLESTITK 1147

  Fly   892 -----ITAPASSRDIQSKLAEFRSFGGRLPKGKAPMLRPKKKNAEVIQRPQKVSEEQLYKDALDP 951
                 :.......:|::...||:.               :.:..||     ..|..|   :.|..
Yeast  1148 KHLGNLIKFLHEMEIENLELEFQK---------------RSRQWEV-----SYSSSQ---NLLGT 1189

  Fly   952 QNHQRLPVLFCSFHYNPKGVSSFCKLPMLLDMKFYGQYDIMLEQFLQ------RYCCLFNSMCPS 1010
            .:||.:.||:......   .::.|..|.::.:.::...||.:.||::      ||.|.     ..
Yeast  1190 GSHQSITVLYSMVSTK---TATPCVGPQIVTIDYFWDSDISIGQFIENVVGTARYPCQ-----QG 1246

  Fly  1011 CNLPMLGHVRRYVHSLGCVHVYLTEDLTRSDPTRIYFTSW--CSICNATTPTIPLSDAAKCLSLA 1073
            ||...|.|.|.|||..|.|.|.:.:..||....:....:|  |..|..:||.:.:|:.....|..
Yeast  1247 CNGLYLDHYRSYVHGSGKVDVLIEKFQTRLPKLKDIILTWSYCKKCGTSTPILQISEKTWNHSFG 1311

  Fly  1074 KYLEMRFHGHAYKRRPPSTDAEQGGTVCEHSLHRDYVHHFSFRGVGAKFQYTPVEV--------- 1129
            ||||:.|  .:||      |:..|...|.|...:|:|.:|.:..:..:.:|:.:||
Yeast  1312 KYLEVMF--WSYK------DSVTGIGKCPHDFTKDHVKYFGYNDLVVRLEYSDLEVHELITPPRK 1368

  Fly  1130 --WETDLPSLTVQLDLPQPFQSAQVQEEIKNFSIKGHEVYNRIHERIADLATEEE---NSPLVQH 1189
              |:   |.:.::|.:...:   ::.|:|.||.   ..|.:|:.....|..|:::   ....:..
Yeast  1369 IKWK---PHIDIKLKVELYY---KILEKINNFY---GSVLSRLERIKLDSMTKDKVLSGQAKIIE 1424

  Fly  1190 LKTMLTHDQFIFKQKIEIVHTLLTDNRATAYDTSDALAMARRALAESIELWG-----------PR 1243
            ||:..|.:|.:..|.::   |...|:..   |....|.:..::|.:....|.           |.
Yeast  1425 LKSNATEEQKLMLQDLD---TFYADSPC---DQHLPLNLVIKSLYDKAVNWNSTFAIFAKSYLPS 1483

  Fly  1244 LQEIEKLTAKQAHHI--DSGTICTEELRPEQVQTADSSKVTTSSLPKEN-DPLECPSEDTETGAS 1305
            ..:|.::||||...:  ||....:|:.:....:.|.:.|...:.||.|. ..:|.|..|::....
Yeast  1484 ETDISRITAKQLKKLFYDSSRKDSEDKKSLHDEKAKTRKPEKNELPLEGLKDVEKPKIDSKNTTE 1548

  Fly  1306 NSQTVLDKNFSIDQMLASTVNVYSDKKSI-----RKILTQLLPSGNQVNPLQSPFPAQ------- 1358
            |      ::.:.:...|.|:..:.|...|     ...|| :.||.:.|:...:|...:
Yeast  1549 N------RDRTNEPQNAVTITTFKDDTPIIPTSGTSHLT-VTPSASSVSSSLTPQTEERPPISRS 1606

  Fly  1359 --------DHLTLP-------------LGSIPIHVRETDLSSVIAYSLTSMDYQKAIDEAEAN-- 1400
                    |..|.|             |.|:.....:.:..|.:|.....|.:.....|.|..
Yeast  1607 GTGISMTHDKSTRPNIRKMSSDSSLCGLASLANEYSKNNKVSKLATFFDQMHFDALSKEFELERE 1671

  Fly  1401 ------SNAAHSSPQLKRKIPLAE---SVSDAEDSPSLSRTSSNTSAAPNASV------------ 1444
                  :...:.:.:|:...|:.|   :|.||.|.|..||:|.|..::.|...
Yeast  1672 RERLQLNKDKYQAIRLQTSTPIVEIYKNVKDAVDEPLHSRSSGNNLSSANVKTLEAPVGEHSRAN 1736

  Fly  1445 ----------------------------PSPATAAS---ESEEKSKERIKQPPSPHITLAFQDHS 1478
                                        ||..|.||   .|:...||..:.|.|
Yeast  1737 NCNPPNLDQNLETELENSISQWGENILNPSGKTTASTHLNSKPVVKETSENPKS----------- 1790

  Fly  1479 CQFQCKIYFAREFDAMRSKSLKP-------------PKLDKSL---------------------- 1508
                    ..||.|..:|:.|.|             |:.:|||
Yeast  1791 --------IVRESDNSKSEPLPPVITTTTVNKVESTPQPEKSLLMKTLSNFWADRSAYLWKPLVY 1847

  Fly  1509 ---------------------------------YR------RLEKSKMREELRISQSRTG----- 1529
                                             ||      .:::.:.::....:.::||
Yeast  1848 PTCPSEHIFTDSDVIIREDEPSSLIAFCLSTSDYRNKMMNLNVQQQQQQQTAEAAPAKTGGNSGG 1912

  Fly  1530 -------------------------SEME--------LVRKPSDVGAPRTTEDDSNQEEDARI-- 1559
                                     ||:.        |:..|...||...|..:|.....|.:
Yeast  1913 TTQTGDPSVNISPSVSTTSHNKGRDSEISSLVTTKEGLLNTPPIEGARDRTPQESQTHSQANLDT 1977

  Fly  1560 ------------------------------------------------ALARSLCKSVQWEARGG 1576
                                                            ...:||.:.|:|::.||
Yeast  1978 LQELEKIMTKKTATHLRYQFEEGLTVMSCKIFFTEHFDVFRKICDCQENFIQSLSRCVKWDSNGG 2042

  Fly  1577 KSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLLAKIFGVFRVSVKKKD 1641
            ||||.|.|||||||::||::..::..|..|||.||||:.:......||.|||:||.:::.||...
Yeast  2043 KSGSGFLKTLDDRFIIKELSHAELEAFIKFAPSYFEYMAQAMFHDLPTTLAKVFGFYQIQVKSSI 2107

  Fly  1642 S---FVERSVMVMENLFYGCNIENKFDLKGSERNRLVDPSNQQGEIVLLDENLVQMSWSKPLYVL 1703
            |   ..:..|::||||||.......||||||.|||.|:.:.:..| ||||||:|:..:..|::|.
Yeast  2108 SSSKSYKMDVIIMENLFYEKKTTRIFDLKGSMRNRHVEQTGKANE-VLLDENMVEYIYESPIHVR 2171

  Fly  1704 SHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGLDKKNGVLVLGIIDYIRTFTLDKRVESIIKGSGI 1768
            .:.|.:||.::..|:.||.|..||||||::|:|.:...|.:||||:|||||.||::||.:|..|:
Yeast  2172 EYDKKLLRASVWNDTLFLAKMNVMDYSLVIGIDNEGYTLTVGIIDFIRTFTWDKKLESWVKEKGL 2236

  Fly  1769 LGGKG--KDPTVVNPERYKQRFIDAMDRYFLTVPDRW--EG 1805
            :||..  |.||||.|.:||:||.:||:||.|.|||.|  ||
Yeast  2237 VGGASVIKQPTVVTPRQYKKRFREAMERYILMVPDPWYREG 2277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264	30/60 (50%)
		DEP	329..397	CDD:214489	17/173 (10%)
		Fab1_TCP	464..717	CDD:239450	86/265 (32%)
		PIPKc	1413..1797	CDD:295374	157/596 (26%)
FAB1	NP_116674.2	PHA03255	<64..>145	CDD:165513	24/84 (29%)
		FYVE_like_SF	236..296	CDD:333710	30/60 (50%)
		Fab1_TCP	797..1056	CDD:239450	86/265 (32%)
		MSS4	1597..2278	CDD:227578	175/701 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343099
Domainoid	1	1.000	145	1.000	Domainoid score	I985
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	541	1.000	Inparanoid score	I175
Isobase	1	0.950	-	0	Normalized mean entropy	S5320
OMA	1	1.010	-	-		QHG58433
OrthoFinder	1	1.000	-	-		FOG0003143
OrthoInspector	1	1.000	-	-		oto100347
orthoMCL	1	0.900	-	-		OOG6_101979
Panther	1	1.100	-	-	LDO	PTHR45748
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2108
SonicParanoid	1	1.000	-	-		X2110
TreeFam	1	0.960	-	-
	15	14.740