Protein Alignment fab1 and FAB1C

DIOPT Version :10

• Sequence 1: NP_611269.1
• Gene: fab1 / 37033
• FlyBaseID: FBgn0028741
• Length: 1809
• Species: Drosophila melanogaster
• Sequence 2: NP_177257.3
• Gene: FAB1C / 843440
• AraportID: AT1G71010
• Length: 1648
• Species: Arabidopsis thaliana
• Alignment Length: 1880
• Identity: 458/1880 - (24%)
• Similarity: 763/1880 - (40%)
• Gaps: 494/1880 - (26%)

  Fly   165 TKNNNDLRNYKDTELQRFWMPDSKAKECYDCSQKFSTFRRKHHCRLCGQIFCSKCCNQVVPGMII 229
            |.:::|......:..|.|.:....:|.|:||..|   ..:.:.|..||..:|..|.:..
plant    20 TSDSSDSLFLLSSSKQDFGIMPIVSKMCHDCGTK---VEQGYCCLSCGSCWCKSCSDTE------ 75

  Fly   230 RCDGDLKVCNYCSKIVLTFLKSSSSEMGQDMQELQQHLSNKLEVQDSGSSLAKHPQMQRAPLPRK 294
              :..:|:|..|.               .:::||:....:|:..:||             |.| .
plant    76 --ESKMKLCRECD---------------AEVRELRVKSYDKVHPRDS-------------PDP-P 109

  Fly   295 TSVGYQEERFSSHPTYTTLSIDDRKNILQQSNSLITLHEEMQRDLPAQNCGQRLIEFLNSNNKSA 359
            :|:..:.|..:|     :|.|.|.:|:     :.|..:.....:..|:.||::|:...:.|.:.:
plant   110 SSLATESESLAS-----SLEIRDCRNM-----ASIRCYPSRGEEEEARYCGKQLLSPSSDNYQDS 164

  Fly   360 NEVQAVAILNAMLAAGFLEPIVPDPEQMDFDSSLHYKFSKSSSSDTSRTMSP------------- 411
            :::::.::                       |:.|..||..||:.:|...||
plant   165 SDIESGSV-----------------------SARHELFSCKSSAGSSPHDSPLRNNFSPLGRFVQ 206

  Fly   412 -------------------------------QFEANPHAE-------------------PQPPKS 426
                                           ..|...|.|                   |.||:.
plant   207 HAKDLRSPTVCSFDNHQEQLLADNLVKPGQGVLEQEDHEEEEDKLQQPLDFENNGRIWYPPPPED 271

  Fly   427 MDQSAEEKEKELENELENDRCYTTATSKLLAS-----------------------YCEHEEQLLA 468
            .:..||......::  |:|....:||...|:|                       ..:|...|:|
plant   272 ENDDAESNYFHYDD--EDDDIGDSATEFSLSSSFSSHIPTKEKLGENSNEPLRTVVHDHFRALVA 334

  Fly   469 QMLRAHNLDQ-------EWDKVLQMLCSTAANHFKPEHCSNDLMDIRNYVNFKKVPGGRRKDSKI 526
            ::||...|..       ||..::..|...|||..||:..:...||..|||..|.|..|.:.:|.:
plant   335 ELLRGEELSPSDDGSAGEWLDIVTALAWQAANFVKPDTRAGGSMDPGNYVKIKCVASGNQNESIL 399

  Fly   527 VHGVAFSKNVAHKDMATHVPFPRILLLQCPIVYERIEGKFVTIETVLLQEKEYLRNVCARIMSFK 591
            :.|:..|||:.||.|.:....||::||...:.|:|:.|:..:..|:|.||.|:::.:.|:|.|.:
plant   400 IRGIVCSKNITHKRMISQYKNPRVMLLAGSLEYQRVAGQLASFNTLLQQENEHMKAIIAKIESLR 464

  Fly   592 PNVVLVHKNVAGIAQDLLRSYEVTLVLDVKLSVMERLSRTLQCDIVSSIESNITMPKLGYCNDFY 656
            |||:||.|:.:..||..|...|::|||:||.|:::|::|.....:..|::| |:..:||:|..|.
plant   465 PNVLLVEKSASSYAQQYLLEKEISLVLNVKRSLLDRIARCTGAVLCPSLDS-ISTARLGHCELFR 528

  Fly   657 IRNY-------------NGKTLMFFEKLTNPRGYTCLLRGGSNAELTRVKRVASALLFARYNWRL 708
            ....             ..:|||:||......|.|.:|||....||.:||.|....:||.|:..|
plant   529 TERVLEQHEAGNQSNRKPSRTLMYFEGCPRRLGCTVVLRGSCREELKKVKHVIQYAVFAAYHLSL 593

  Fly   709 EMSFLLNEFAQPLSPKPSIFDSKETSPKTETEAELRSKRPIILERKSEDKITTIVSENVSDFTDP 773
            |.|||.:|.|              :.||      :|.|:|.::...|:.:   |:.|.:|..|..
plant   594 ETSFLADEGA--------------SLPK------IRLKQPGMVRTASQRR---IIDEGISLITQS 635

  Fly   774 LRASQAEALSTSPCAPPVVEALAVEPRYDNRFRTALSSTLLSVSPFLTFPLPYLETEQGRKCKL- 837
            ...:.::||         :|..|.|..:                   |.|:|..|.     |:.
plant   636 PTETDSQAL---------LETAAHEDEH-------------------TAPMPEHEV-----CESL 667

  Fly   838 ------RKLFPAELYFSKQWSRTGLERPDSMGDGEAGKSEPGNKENQMQLLPAHDFVLMKITAPA 896
                  .::||..       |....|:.|:: :|:...:......:..||...|:..|.
plant   668 CEDFDPTQIFPPS-------SEVETEQSDTL-NGDFANNLVTRSYSSNQLNDLHEPTLC------ 718

  Fly   897 SSRDIQSKLAEFRSFGGRLPKGKAPMLRPKKKNAEVIQRPQKVSE-EQLYKDALDPQ------NH 954
                :.|::.|..:   :.|.|:....|.:::|..|  .||.:.: |..|:|.:..:      :|
plant   719 ----LSSEIPETPT---QQPSGEEDNGRGEEENQLV--NPQDLPQHESFYEDDVSSEYFSAADSH 774

  Fly   955 QRLPVLFCSFHYNPKGV--SSFCKLPMLLDMKFYGQYDIMLEQFLQRYCCLFNSMCPSCNLPMLG 1017
            |.:.|.|.|     :.|  .|.|:...||.:||||.:|..|.::|:.......|.|.||...:..
plant   775 QSILVSFSS-----RCVLKESVCERSRLLRIKFYGSFDKPLGRYLKDDLFDKTSSCRSCKELVDA 834

  Fly  1018 HVRRYVHSLGCVHVYL----TEDLTRSDPTRIYFTSWCSIC------NATTPTIPLSDAAKCLSL 1072
            ||..|.|..|.:.:.:    :..|......:|:....|..|      ...|..:.:||||..||.
plant   835 HVLCYSHQNGNLTINVRRLPSMKLPGEQDGKIWMWHRCLRCAHVDGVPPATRRVVMSDAAWGLSF 899

  Fly  1073 AKYLEMRFHGHAYKRRPPSTDAEQGGTVCEHSLHRDYVHHFSFRGVGAKFQYTPVEVWETDLPSL 1137
            .|:||:.|..||...|..|         |.|||.||.:..:.|..:.|.|:|:|:.:....||..
plant   900 GKFLELSFSNHATANRVAS---------CGHSLQRDCLRFYGFGNMVAFFRYSPINILTVLLPPS 955

  Fly  1138 TVQLDL-PQP----FQSAQVQEEIKNFSIKGHEVYNRIHERIADLATEEENSPLVQHLKTMLTHD 1197
            .::.:. ||.    .::|::..:::....:..::.||:.|: :.|...|::.....|.:.:...|
plant   956 MLEFNSHPQQEWIRTEAAELVGKMRTMYTEISDMLNRMEEK-SSLLEPEQSEACDLHSRIIGLID 1019

  Fly  1198 QFIFKQKIEIVHTL--LTDNRATAYDTSDALAM--ARRALAESIELW------------------ 1240
            |.: |:|.|....|  :.:.......:.|.|.:  .||||......|
plant  1020 QLV-KEKDEYDDALQPIFEENLQIQGSLDILELNRLRRALMIGAHAWDHQLYLLNSQLKKASVFK 1083

  Fly  1241 --------GPRLQEIEKLTAK---------QAHHIDS---------------GTICTEEL----- 1268
                    .|.:.:..|:..:         :..|.||               ||..:|.:
plant  1084 TGDDNAPRNPEMHDPPKIDRRMQEGSDERDEQSHTDSEANGDNKDPENIPSPGTSLSERIDSAWL 1148

  Fly  1269 -------RPEQVQTADSSKVTTSSLPKENDPLECPSEDTETGASNSQTVLDKNFSIDQMLASTV- 1325
                   :.|.:...:......|||.:...|:...|.|:   |...|..:.|......:..||:
plant  1149 GSFQNLEKAETIAETEGFSAVNSSLRRLARPIRVQSFDS---AIRFQERIQKGLPPSSLYLSTLR 1210

  Fly  1326 ---------NVYSDKKS-IRKILTQLLP---------SGNQVNPLQSPFPAQD--HLTLP---LG 1366
                     |:..|..| :.:..:|:||         .|:....:.|.....|  .:.:|   |.
plant  1211 SFHASGEYRNMVRDPVSNVMRTYSQMLPLEVQKLDLIVGSAPTYISSASQMADGARMLIPQRGLN 1275

  Fly  1367 SIPIHVRETDLSSVIAYSLTSMDYQKAIDEAEANSNAAHSSPQLKRKIPLAESVSDAEDSPSLSR 1431
            .|.:.|.:.|.:||::|::.|.:|::.|    .|...|.||.        :.::::.|..||...
plant  1276 DIVVPVYDDDPASVVSYAINSKEYKEWI----VNKGLASSSS--------SSNLNNRESEPSAFS 1328

  Fly  1432 TSSNTSAAPNASVPSPATAASESEEKSKERIKQPPSPHITLAFQDHS----------CQFQCKIY 1486
            |..:.|.  :......|...|..:::.        |||:|::|.|.:          .:|....|
plant  1329 TWRSLSM--DVDYIQHAVYGSSQDDRK--------SPHLTISFSDRASSSSTATEGKVKFSVTCY 1383

  Fly  1487 FAREFDAMRSKSLKPPKLDKSLYRRLEKSKMREELRISQSRTGSEMELVRKPSDVGAPRTTEDDS 1551
            ||.:||.:| |:..|.::|
plant  1384 FATQFDTLR-KTCCPSEVD---------------------------------------------- 1401

  Fly  1552 NQEEDARIALARSLCKSVQWEARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDR 1616
                     ..|||.:..:|.|:||||...|.|:||:||::|::...::..||.|||:||:|:..
plant  1402 ---------FVRSLSRCQRWSAQGGKSNVYFAKSLDERFIIKQVVKTELDSFEDFAPEYFKYLKE 1457

  Fly  1617 CQQQQQPTLLAKIFGVFRVSVK--KKDSFVERSVMVMENLFYGCNIENKFDLKGSERNRLVDPSN 1679
            ......||.||||.|:::||:|  |.....:..:||||||||...|...:|||||.|:| .:|:.
plant  1458 SLSSGSPTCLAKILGIYQVSIKHPKGGKETKMDLMVMENLFYNRRISRIYDLKGSARSR-YNPNT 1521

  Fly  1680 QQGEIVLLDENLVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGLDKKNGVLVL 1744
            ...:.||||.||::...::|:::.|.:|..|..||..|::||....|||||||||.|::...|||
plant  1522 SGADKVLLDMNLLETLRTEPIFLGSKAKRSLERAIWNDTNFLASVDVMDYSLLVGFDEERKELVL 1586

  Fly  1745 GIIDYIRTFTLDKRVESIIKGSGILGG-KGKDPTVVNPERYKQRFIDAMDRYFLTVPDRW 1803
            ||||::|.:|.||.:|:.:|.|||||| |...||:|:|::||:||..||..||||||:.|
plant  1587 GIIDFMRQYTWDKHLETWVKASGILGGPKNASPTIVSPKQYKRRFRKAMTTYFLTVPEPW 1646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264	14/60 (23%)
		DEP	329..397	CDD:214489	8/67 (12%)
		Fab1_TCP	464..717	CDD:239450	92/272 (34%)
		PIPKc_PIKfyve	1479..1796	CDD:340437	117/319 (37%)
FAB1C	NP_177257.3	Fab1_TCP	330..602	CDD:239450	92/272 (34%)
		PIPKc_PIKfyve	1376..1639	CDD:340437	117/319 (37%)