DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fab1 and PIP4K2B

DIOPT Version :9

Sequence 1:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	XP_011523628.1	Gene:	PIP4K2B / 8396	HGNCID:	8998	Length:	443	Species:	Homo sapiens

Alignment Length:	313	Identity:	68/313 - (21%)
Similarity:	113/313 - (36%)	Gaps:	103/313 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1576 GKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFE---------------------YIDRCQ- 1618
            |:.|:||..|.|.|||:|.::|.|:........||.:                     :..||:
Human   133 GRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQMAGSLACLCILSLPCGIPISGWQKRCKF 197

  Fly  1619 --QQQQPTLLAKIFGVFRVSVKKKDSFVERSVMVMENLF-YGCNIENKFDLKGSERNRLVDPSNQ 1680
              :....|||.:..|::|::|    ..||..::|..|:| :...:..|:|||||...|......:
Human   198 IVECHGNTLLPQFLGMYRLTV----DGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEK 258

  Fly  1681 QGEIVLLDENLVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGL---------- 1735
            ..::....:|.. ::..:.|:|...||....:.::||..||.:..:||||||||:
Human   259 AKDLPTFKDNDF-LNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEE 322

  Fly  1736 -------------------------------------------------------------DKKN 1739
                                                                         ..|.
Human   323 MEVEERAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKK 387

  Fly  1740 GVLVLGIIDYIRTFTLDKRVESIIKGSGILGGKGKDPTVVNPERYKQRFIDAM 1792
            .|..:.|||.:..:...|:.....|  .:..|.|.:.:.||||:|.:||.:.|
Human   388 EVYFMAIIDILTPYDTKKKAAHAAK--TVKHGAGAEISTVNPEQYSKRFNEFM 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264
		DEP	329..397	CDD:214489
		Fab1_TCP	464..717	CDD:239450
		PIPKc	1413..1797	CDD:295374	68/313 (22%)
PIP4K2B	XP_011523628.1	PIPKc	39..443	CDD:238081	68/313 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810