Protein Alignment fab1 and PIP5K1A

DIOPT Version :9

• Sequence 1: NP_611269.1
• Gene: fab1 / 37033
• FlyBaseID: FBgn0028741
• Length: 1809
• Species: Drosophila melanogaster
• Sequence 2: XP_006711626.1
• Gene: PIP5K1A / 8394
• HGNCID: 8994
• Length: 574
• Species: Homo sapiens
• Alignment Length: 493
• Identity: 96/493 - (19%)
• Similarity: 159/493 - (32%)
• Gaps: 155/493 - (31%)

  Fly  1364 PLGSIPIHVRETDLSSVIAYSLTSMDYQK----AIDEAEANSNAAHSSPQLKRKIPLAESVSDAE 1424
            |:.|..:..|:....|::.|: :.|..:|    ::|.:...:....:|..||..|.|
Human    48 PMASEVLEARQDSYISLVPYA-SGMPIKKIGHRSVDSSGETTYKKTTSSALKGAIQL-------- 103

  Fly  1425 DSPSLSRTSSNTSAAPNASVPSPATAASESEEKSKERIKQPPSPHITLAFQDHSCQFQCKIYFAR 1489
               .::.|..:.|..|...|........||.....|.....|:.|    :.|    |:.|.|...
Human   104 ---GITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHH----YND----FRFKTYAPV 157

  Fly  1490 EFDAMRSK-SLKPPKLDKSLYRRLEKSKMREELRISQSRTGSEMELVRKPSDVGAPRTTEDDSNQ 1553
            .|...|.. .::|   |..||                       .|..:|
Human   158 AFRYFRELFGIRP---DDYLY-----------------------SLCSEP--------------- 181

  Fly  1554 EEDARIALARSLCKSVQWEARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRCQ 1618
                    ...||.|       |.|||.|..:.||.|::|.:..::....:...|.|:..::
Human   182 --------LIELCSS-------GASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLN--- 228

  Fly  1619 QQQQPTLLAKIFGVFRVSVKKKDSFVERSVMVMENLF-YGCNIENKFDLKGSERNRLVDPSNQQG 1682
             |...|||.|.:|::.|....|:.    .::||.||. ....:..|:|||||...|......::.
Human   229 -QNPRTLLPKFYGLYCVQAGGKNI----RIVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREK 288

  Fly  1683 EIVLLDENLVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLV-------------- 1733
            .:....:..........|::.:.....|...:|||...|:...:||||||:
Human   289 PLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLS 353

  Fly  1734 -------------------------------------------GLDKKNG-----VLVLGIIDYI 1750
                                                       |:..:|.     :|.:||||.:
Human   354 SETQYSVDTRRPAPQKALYSTAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDIL 418

  Fly  1751 RTFTLDKRVESIIKGSGILGGKGKDPTVVNPERYKQRF 1788
            :::...|::|...|.   |...|...:|..|..|.:||
Human   419 QSYRFVKKLEHSWKA---LVHDGDTVSVHRPGFYAERF 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264
		DEP	329..397	CDD:214489
		Fab1_TCP	464..717	CDD:239450
		PIPKc	1413..1797	CDD:295374	85/440 (19%)
PIP5K1A	XP_006711626.1	PIPKc	121..461	CDD:214623	79/408 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810