DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fab1 and FAB1A

DIOPT Version :9

Sequence 1:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	NP_001320122.1	Gene:	FAB1A / 829460	AraportID:	AT4G33240	Length:	1757	Species:	Arabidopsis thaliana

Alignment Length:	1933	Identity:	497/1933 - (25%)
Similarity:	787/1933 - (40%)	Gaps:	528/1933 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 RNYKDTELQR-FWMPDSKAKECYDCSQKFSTFRRKHHCRLCGQIFCSKCCNQVVPGMIIRCDGD- 234
            |..:.:.:.| |||||.....||:|..:|:.|.|:|||||||::||:||....:|.     ..|
plant    21 RKSESSNMSRDFWMPDQSCPVCYECDAQFTVFNRRHHCRLCGRVFCAKCAANSIPS-----PSDE 80

  Fly   235 ----------LKVCNYCSK-----IV-------LTFLKSSSSEMGQDMQELQQHLSNKLEVQDSG 277
                      ::|||||.|     ||       :..|..|||...:.:.....:.||.  ..||.
plant    81 TKDSHEEPERIRVCNYCYKQWEQGIVPPDNGASIISLHFSSSPSARSVASTTSNSSNC--TIDST 143

  Fly   278 SSLAKHPQMQ-RAPLPRKTSVGYQEERFSSHPTYTTLSIDDRKNILQQSNSLITLHEEMQRDLPA 341
            :..:..|:|. ||  .|:.|.....|:.......:..|.|...::|..|::.:..
plant   144 AGPSPRPKMNPRA--SRRVSSNMDSEKSEQQNAKSRRSSDHYGHVLDSSDNQVEF---------- 196

  Fly   342 QNCGQRLIEFLNSNNKSANE-----------VQAVAILNAMLAAGFLE----------------P 379
                     |:||:.:|..|           .|:.|..|....|..|:                .
plant   197 ---------FVNSSGRSDGEADDDDDYQSDFAQSYAQGNDYYGAINLDEVDHIYGSHEAHDVGVK 252

  Fly   380 IVPD----PEQMDFDSSLHYKFSKSSSSDTS----RTMSPQFEANPHAEPQ------------PP 424
            |.|:    |...|.||.......|:...:..    :..||..|.:  .||:            ||
plant   253 IEPNISGFPPDQDLDSLNTETIDKTRQQENGWNDVKEGSPPCEES--FEPEVVDFESDGLLWLPP 315

  Fly   425 KSMDQSAEEKEKELENE-------------------LENDRCYTTATSKLLASYCE-HEEQLLAQ 469
            :. :...:|:|..|.::                   .|.|......:|..:.:..| |...|:||
plant   316 EP-ENEEDEREAVLSDDDGDEGDRGDWGYLRPSNSFNEKDFHSKDKSSGAMKNVVEGHFRALVAQ 379

  Fly   470 MLRAHNL------DQE-WDKVLQMLCSTAANHFKPEHCSNDLMDIRNYVNFKKVPGGRRKDSKIV 527
            :|...||      |:| |..::..|...||...||:...:..||...||..|.:|.|||.:|.:|
plant   380 LLEVDNLPMVNEGDEEGWLDIITSLSWEAATLLKPDTSKSGGMDPGGYVKVKCIPCGRRSESMVV 444

  Fly   528 HGVAFSKNVAHKDMATHVPFPRILLLQCPIVYERIEGKFVTIETVLLQEKEYLRNVCARIMSFKP 592
            .||...|||||:.|.:.:..||:|:|...:.|:||..:..:.:|:|.||.::|:...|:|.|..|
plant   445 KGVVCKKNVAHRRMTSKIEKPRLLILGGALEYQRISNQLSSFDTLLQQEMDHLKMAVAKIDSHNP 509

  Fly   593 NVVLVHKNVAGIAQDLLRSYEVTLVLDVKLSVMERLSRTLQCDIVSSIESNITMPKLGYCNDFYI 657
            :::||.|:|:..||:.|.:.:::|||::|.|::||:||.....||.||: .:|.||||||:.|::
plant   510 DILLVEKSVSRFAQEYLLAKDISLVLNIKRSLLERISRCTGAQIVPSID-QLTSPKLGYCDLFHV 573

  Fly   658 RNY-------------NGKTLMFFEKLTNPRGYTCLLRGGSNAELTRVKRVASALLFARYNWRLE 709
            ..:             ..||||||:....|.|.|.||:|....||.:||.|....:||.|:..||
plant   574 EKFVETHVSPCQVAKKMAKTLMFFDGCPKPLGCTILLKGAHEDELKKVKHVIQYGVFAAYHLALE 638

  Fly   710 MSFLLNEFAQ------------PLSPKPSIFD------------SKETSPKTETEAELRSKRPII 750
            .|||.:|.|.            .|..|||:.:            |.|.||.||...|
plant   639 TSFLADEGASIHELPLQTPITVALPDKPSMVNRSISTIPGFTVSSAEKSPTTELRGE-------- 695

  Fly   751 LERKSEDKITTIVSENVSDFTDPL----RASQAEA----LSTSPCAPPVVEALAVEPRYDNRFRT 807
             ..|:...:|...:.:.:.|...|    |...:|.    |.|..|.||
plant   696 -PHKANGDLTGNFTSSKTHFQGKLDGNDRIDPSERLLHNLDTVYCKPP----------------- 742

  Fly   808 ALSSTLLSVSPFLTFPLPYLETEQGRKCKLRKLFPAELYFSKQWSRTGLERPDSMGDGEAGKSEP 872
               .|:.|....|   :|.||:.|             |.|..:                    ||
plant   743 ---ETITSKDDGL---VPTLESRQ-------------LSFHVE--------------------EP 768

  Fly   873 GNKENQMQLLPAHDFVLMKITAPASSRDIQSKLAEFRSFGGRLPKGKAPMLRPKKKNAEVIQRPQ 937
            ..:::|..:|..   ...::|....:.|  |.:...::|..                    |...
plant   769 SVQKDQWSVLSG---ATEQVTDGGYTND--SAVIGNQNFNR--------------------QEQM 808

  Fly   938 KVSEEQLYKDALDPQNHQRLPVLF---CSFHYNPKGVSSFCKLPMLLDMKFYGQYDIMLEQFLQR 999
            :.|:...:..|.|   ||.:.|..   |.:    ||  |.|:...||.:|:||.:|..|.:||:.
plant   809 ESSKGDFHPSASD---HQSILVSLSTRCVW----KG--SVCERAHLLRIKYYGSFDKPLGRFLRD 864

  Fly  1000 YCCLFNSMCPSCNLPMLGHVRRYVHSLGCVHV---YLTEDLTRSDPTRIYFTSWCSIC---NATT 1058
            .....:..||||.:|...|:..|.|..|.:.:   .|.|.|......:|:....|..|   |...
plant   865 NLFDQDQCCPSCTMPAEAHIHCYTHRQGSLTISVKKLPELLPGQREGKIWMWHRCLKCPRINGFP 929

  Fly  1059 PT---IPLSDAAKCLSLAKYLEMRFHGHAYKRRPPSTDAEQGGTVCEHSLHRDYVHHFSFRGVGA 1120
            |.   |.:||||..||..|:||:.|..||...|..:         |.||||||.:..:.|..:.|
plant   930 PATRRIVMSDAAWGLSFGKFLELSFSNHAAASRVAN---------CGHSLHRDCLRFYGFGRMVA 985

  Fly  1121 KFQYTPVEVWETDLPSLTVQLDLPQPFQSAQ-VQEEIKNFSIKGHEVYNRIHERIADL------A 1178
            .|:|..:.::...||...:..:    :::.: :|:|.|....|...::|.:.|.::.:      |
plant   986 CFRYASINIYAVTLPPAKLYFN----YENQEWLQKESKEVIKKAEVLFNEVQEALSQISAKTMGA 1046

  Fly  1179 TEEENSP-----LVQHLKTMLTHDQFIFKQKIEIVHTLLTDNRAT----------------AYDT 1222
            ..:.::|     .::.|..:|...:..:|..::.:..::.|.:.|                :|..
plant  1047 GSKGSTPNKIKLSLEELAGLLEQRKKEYKDSLQQMLNVVKDGQPTIDILLINKLRRLIIFDSYAW 1111

  Fly  1223 SDALA----MARRALAESIELWGPRLQ----EIEKLTAKQAHHIDSG-TICTEELRPEQVQTAD- 1277
            .:.||    |.|....|:.:...|::.    .:|||:.::...|.:. .||.:.|    :|.||
plant  1112 DECLAGAANMVRNNYLEAPKNSAPKVMGRNVSLEKLSDEKVKSIPTHVAICNDSL----LQDADY 1172

  Fly  1278 -------SSKVTTS---SLPKE---NDPLEC-----PSEDTETGASNSQTVLDKNFSIDQMLAST 1324
                   .|...||   ::|::   :.|.:|     |||..:.....|..|:....:..|..|:.
plant  1173 ETCLNQGKSFADTSGKFAIPEDVGSDRPPDCRMEFDPSEGGKDNFVESSQVVKPAHTESQFQATD 1237

  Fly  1325 VNVYSDKKSIRKILT-----------------------QLLPSGNQVN------------PLQSP 1354
            ::...|...|.:..|                       :||.|.:::|            .:|.|
plant  1238 LSDTLDAAWIGEQTTSENGIFRPPSRAASTNGTQIPDLRLLGSESELNFKGGPTNDEHTTQVQLP 1302

  Fly  1355 FP-------------------AQD-----------------HLTLPLG--SIPIHVRETDLSSVI 1381
            .|                   |:|                 .|.||||  .:.:.|.:.:.:|:|
plant  1303 SPSFYYSLNKNYSLNSRKHIMAEDRPVYVSSYRELEWRSGARLLLPLGCNDLVLPVYDDEPTSII 1367

  Fly  1382 AYSLTSMDYQKAIDEAEANSNAAHSSPQLKRKIPLAESVSDAEDSPSLSRTSSNTSAAPNASVPS 1446
            ||:|||.:|:..:..::.:.:...|....        |:.|:.:..||:..|       :.||..
plant  1368 AYALTSSEYKAQMSGSDKSRDRLDSGGSF--------SLFDSVNLLSLNSLS-------DLSVDM 1417

  Fly  1447 PATAASESEEKS---------KERIKQPPSPHITLAFQDH----SCQFQCKIYFAREFDAMRSKS 1498
            ..:.:|..|:.|         |:.       |..::|.|.    ..::....|:|:||:|:|.
plant  1418 SRSLSSADEQVSQLLHSSLYLKDL-------HARISFTDEGPPGKVKYSVTCYYAKEFEALRM-- 1473

  Fly  1499 LKPPKLDKSLYRRLEKSKMREELRISQSRTGSEMELVRKPSDVGAPRTTEDDSNQEEDARIALAR 1563
                                                      :..|..|:            ..|
plant  1474 ------------------------------------------ICCPSETD------------FIR 1484

  Fly  1564 SLCKSVQWEARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLLAK 1628
            ||.:..:|.|:||||...|.|:|||||::|::...::..|..|.|.||:|:......:.||.|||
plant  1485 SLGRCRKWGAQGGKSNVFFAKSLDDRFIIKQVTKTELESFIKFGPAYFKYLTESISTKSPTSLAK 1549

  Fly  1629 IFGVFRVSVK--KKDSFVERSVMVMENLFYGCNIENKFDLKGSERNRLVDPSNQQGEIVLLDENL 1691
            |.|:::||.|  |.....:..|:|||||.:..|....:|||||.|.| .:|.......||||:||
plant  1550 ILGIYQVSSKHLKGGKEFKMDVLVMENLLFKRNFTRLYDLKGSTRAR-YNPDTSGSNTVLLDQNL 1613

  Fly  1692 VQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGLDKKNGVLVLGIIDYIRTFTLD 1756
            |:...:.|::|.|.:|.:|..|:..|:|||....|||||||||:|::...|||||||::|.:|.|
plant  1614 VEAMPTSPIFVGSKAKRLLERAVWNDTSFLASIHVMDYSLLVGVDEERNELVLGIIDFMRQYTWD 1678

  Fly  1757 KRVESIIKGSGILGG-KGKDPTVVNPERYKQRFIDAMDRYFLTVPDRW 1803
            |.:|:.:|.||:||| |...|||::|::||:||..||..|||.|||:|
plant  1679 KHLETWVKTSGLLGGPKNSTPTVISPQQYKKRFRKAMTAYFLMVPDQW 1726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264	29/71 (41%)
		DEP	329..397	CDD:214489	16/98 (16%)
		Fab1_TCP	464..717	CDD:239450	102/272 (38%)
		PIPKc	1413..1797	CDD:295374	128/399 (32%)
FAB1A	NP_001320122.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	153	1.000	Domainoid score	I1366
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	546	1.000	Inparanoid score	I258
OMA	1	1.010	-	-		QHG58433
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003143
OrthoInspector	1	1.000	-	-		otm3014
orthoMCL	1	0.900	-	-		OOG6_101979
Panther	1	1.100	-	-	O	PTHR45748
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2110
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830