DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fab1 and PIP4K2C

DIOPT Version :9

Sequence 1:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	NP_001139730.1	Gene:	PIP4K2C / 79837	HGNCID:	23786	Length:	421	Species:	Homo sapiens

Alignment Length:	308	Identity:	69/308 - (22%)
Similarity:	124/308 - (40%)	Gaps:	87/308 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1564 SLCKSVQWEARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLLAK 1628
            ||.::...|:.|  |..||..:.|...|:||::|.|:.........|.:||.:|...   |||.:
Human   125 SLTRNPPSESEG--SDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGN---TLLPQ 184

  Fly  1629 IFGVFRVSVKKKDSFVERSVMVMENLF-YGCNIENKFDLKGSERNRLVDPSNQQGEIVLLDENLV 1692
            ..|::||||..:||:    ::||.|:| :...:..|:|||||..:|......:..|:..| :::.
Human   185 FLGMYRVSVDNEDSY----MLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTL-KDMD 244

  Fly  1693 QMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGLD--------------------- 1736
            .::.::.:|:....|.:..:.::||..||.:..:||||||:|:.
Human   245 FLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEV 309

  Fly  1737 -----------------------------------------------------KKNGVLVLGIID 1748
                                                                 .:..|..:|:||
Human   310 DGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLID 374

  Fly  1749 YIRTFTLDKRVESIIKGSGILGGKGKDPTVVNPERYKQRFIDAMDRYF 1796
            .:..:...|:.....|  .:..|.|.:.:.|:||:|.:||:|.:...|
Human   375 ILTQYDAKKKAAHAAK--TVKHGAGAEISTVHPEQYAKRFLDFITNIF 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264
		DEP	329..397	CDD:214489
		Fab1_TCP	464..717	CDD:239450
		PIPKc	1413..1797	CDD:295374	69/308 (22%)
PIP4K2C	NP_001139730.1	Required for interaction with PIP5K1A. /evidence=ECO:0000269\|PubMed:31091439	69..75
PIP4K2C	NP_001139730.1	PIPKc	72..420	CDD:214623	68/306 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810