DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fab1 and Rufy2

DIOPT Version :9

Sequence 1:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	NP_081701.2	Gene:	Rufy2 / 70432	MGIID:	1917682	Length:	606	Species:	Mus musculus

Alignment Length:	291	Identity:	58/291 - (19%)
Similarity:	108/291 - (37%)	Gaps:	73/291 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KLTEFARNFEDKPESLFG--RVVNKIQNVYNQSYNTVNDISSGSSSSSS---------------- 66
            ||.|  ::..:|.::|.|  :.:.:::.:..:.|..:.....|....:.
Mouse   334 KLLE--KDIHEKQDTLIGLRQQLEEVKAINIEMYQRLQGSEDGLKEKNEIIARLEEKTNKITTAM 396

  Fly    67 ---TQPVQVVGKSQFFSDSQTS--TAEIADVETSSQSSVRPQPPTTLSIRTN----SETRGTSTS 122
               .|.:|...|:|..::::..  ..|......|.|..:..:....:.:.|:    .|.|.|...
Mouse   397 RQLEQRLQQAEKAQKEAEAEDEKYAQECLSQSDSLQRQISQKEQQLVQLETDLKIEKEWRQTLQE 461

  Fly   123 SNTAAEDSETSDRVETLPLPTSEANQGRTVSNVLKHISNIVATKNNNDLRNYKDTE--LQRF--- 182
            .....:|..:..|.||           :.|.::.|...|: ..:|....|.|::.|  ||..
Mouse   462 DLQKEKDVLSHLRHET-----------QKVISLKKEFLNL-QDENQQLKRIYQEQEQALQELGSK 514

  Fly   183 ----------------------WMPDSKAKECYDCSQKFSTFRRKHHCRLCGQIFCSKCCNQVVP 225
                                  |:.|..|..|..|.::||..:||||||.||:|||:.|.:..:|
Mouse   515 LCESKLKIDDIKEANKALQGLVWLKDKDATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELP 579

  Fly   226 GMIIRCDGDLKVCNYCSKIVLTFLKSSSSEM 256
              :......::||:.|..::   ::..||.|
Mouse   580 --LPSSPKPVRVCDSCHAML---IQRCSSNM 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264	23/85 (27%)
		DEP	329..397	CDD:214489
		Fab1_TCP	464..717	CDD:239450
		PIPKc	1413..1797	CDD:295374
Rufy2	NP_081701.2	RUN	45..168	CDD:280855
		Taxilin	209..535	CDD:286771	32/214 (15%)
		DUF972	223..>295	CDD:283750
		GBP_C	<326..510	CDD:303769	31/189 (16%)
		coiled coil	497..507	CDD:293879	3/9 (33%)
		FYVE_RUFY2	534..604	CDD:277298	24/74 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2108
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030