DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fab1 and pip4k2aa

DIOPT Version :9

Sequence 1:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	NP_001122174.1	Gene:	pip4k2aa / 560360	ZFINID:	ZDB-GENE-080721-18	Length:	404	Species:	Danio rerio

Alignment Length:	313	Identity:	72/313 - (23%)
Similarity:	127/313 - (40%)	Gaps:	88/313 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1554 EEDARIALARS--LCKSVQWEARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDR 1616
            ::|.:.:|.||  |....|     |:||:||..:.|.|:|:|.::|.|:........||.:||..
Zfish   108 DQDFQNSLTRSAPLVSEAQ-----GRSGARFHTSYDKRYVIKTISSEDVAEMHNILKKYHQYIVE 167

  Fly  1617 CQQQQQPTLLAKIFGVFRVSVKKKDSFVERSVMVMENLF-YGCNIENKFDLKGSERNRLVDPSNQ 1680
            |...   |||.:..|::|::|...:::    ::|..|:| :..::..|:|||||...|......:
Zfish   168 CHGS---TLLPQFLGMYRLTVDGDETY----MIVTRNVFSHRLSVYKKYDLKGSTVAREASDKEK 225

  Fly  1681 QGEIVLLDENLVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGL---------- 1735
            ..|:....:|.. ::..:.:|:...||.:..:.:|:|..||....:||||||||:
Zfish   226 AKELPTYKDNDF-INDGQKIYIDDESKKIFLNKLQKDVEFLALLKLMDYSLLVGIHDVERAEQEE 289

  Fly  1736 -------------------------------------------------------DKKNGVLVLG 1745
                                                                   ..:..|..:.
Zfish   290 VESEDNEGEEEGESDGGIVGTPPDSPSNTLDSTKPLSPGDFDPNIDVYAIKSHDNSPRKEVYFMA 354

  Fly  1746 IIDYIRTFTLDKRVESIIKGSGILGGKGKDPTVVNPERYKQRFIDAMDRYFLT 1798
            :||.::.:...|:.....|  .:..|.|.:.:.||||:|.:||.|     |:|
Zfish   355 VIDILQHYDAKKKAAHAAK--TVKHGAGAEISTVNPEQYSKRFYD-----FIT 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264
		DEP	329..397	CDD:214489
		Fab1_TCP	464..717	CDD:239450
		PIPKc	1413..1797	CDD:295374	70/310 (23%)
pip4k2aa	NP_001122174.1	PIPKc	61..403	CDD:214623	72/313 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810