Protein Alignment fab1 and pikfyve

DIOPT Version :10

• Sequence 1: NP_611269.1
• Gene: fab1 / 37033
• FlyBaseID: FBgn0028741
• Length: 1809
• Species: Drosophila melanogaster
• Sequence 2: NP_001362234.2
• Gene: pikfyve / 550069
• XenbaseID: XB-GENE-989454
• Length: 2104
• Species: Xenopus tropicalis
• Alignment Length: 2199
• Identity: 647/2199 - (29%)
• Similarity: 985/2199 - (44%)
• Gaps: 530/2199 - (24%)

  Fly    17 SPSKLTEFARNFEDKPESLFGRVVNKIQNVYNQSYNTVNDISSGSSSSSSTQPVQVVGKSQFFSD 81
            |||.||.|.....|:.:..|....:...:::..|.:.|...::...|...|            :|
 Frog    23 SPSHLTHFKPLTPDQDDPPFKSAYSSFVSLFRFSKDEVRAATTFDKSDRGT------------ND 75

  Fly    82 SQTSTAEIADVETSSQSSVRPQPPTTLSIRTNSETRGTSTSSNTAAEDSETSDRVETLPL---PT 143
            ....:|..:....||..|:|  .|.....::.:|.||::|        |:|..:.|. ||   |.
 Frog    76 PALRSAWPSPHHFSSSHSIR--SPVQYKKQSLAERRGSAT--------SDTHRKAEP-PLGHDPR 129

  Fly   144 SEANQGRTVSNVLKHISNIVATKNNNDLRNYKDTELQRFWMPDSKAKECYDCSQKFSTFRRKHHC 208
            : |.|.|:::.|||.:..|:..|:       :|::|:::|||||:.|||||||:||:||||:|||
 Frog   130 T-AVQLRSLTTVLKRLKEIMEGKS-------QDSDLKQYWMPDSQCKECYDCSEKFTTFRRRHHC 186

  Fly   209 RLCGQIFCSKCCNQVVPGMIIRCDGDLKVCNYCSKIVLTFLKSS-SSEMGQDMQEL--------- 263
            |||||||||:||||.:||..:...|||:.|.||.||.:.:..|| |:.:|:|:..|
 Frog   187 RLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCCKIAVNYAHSSDSNTIGEDLTALSDSSCSISL 251

  Fly   264 --------------------------------QQHLSNKLEV------QDSGSSLAKHP------ 284
                                            |::..|.|..      :|.|.|.|::.
 Frog   252 LDPGEPRTPVGGRKSSRNIFLEEDLAWQSLVHQENPKNTLTTRLASVQEDVGKSPARNRSASITN 316

  Fly   285 -QMQR--APL--PRKTSVGYQEERFSSHPTYTTLSI-DDRKNILQQSNSLITL------------ 331
             .:.|  :|:  |.::||..|..|     ||..... ::.:.||..|..|..|
 Frog   317 LSLDRSGSPMVPPYESSVSPQSSR-----TYLKNDTNEEERKILLDSVQLKELWKKICHNNSGME 376

  Fly   332 ---HEEMQRDLPAQNC--GQRLIEFLNSNNKSANEVQAVAILNAMLAAGFLEPI----------- 380
               |....|..|  ||  |:.|:.:|..|.......||:||..|::...:|:.:
 Frog   377 FQDHRYWLRTHP--NCIVGKDLVNWLIRNGHITTRAQAIAIGQALVDGRWLDCVTHHDQLFRDEY 439

  Fly   381 -------------VPDPE-----------------QMDFDSS----------------------- 392
                         .|.|:                 .:.||.|
 Frog   440 ALYRPLQSTEFSETPSPDSDSVNSVEGHSEPSWFKDIKFDDSDTEQIADEGEDNLTNSTSPSKRT 504

  Fly   393 LHYKFSKSSSSDTSRTMSPQFEAN------------PHAEPQP-----------------PKS-- 426
            ....|..:..||::.::|...|.:            ||..|.|                 |.|
 Frog   505 SVSSFQSAMDSDSAASISLNVEMDNVNFHIKKHSKYPHVPPHPADQKEFLLSEDGGQQIVPISDA 569

  Fly   427 ------MDQSAEEKEKEL-----------ENELENDRCYTTATSKLLASYCEHEEQLLAQMLRAH 474
                  .::..|||.|:|           .::|..:.....|..:||::...|...||.|:|...
 Frog   570 FIKESLFNRRVEEKSKDLLFTPLGWHHNNLDQLREENGEKQAMERLLSANHNHMMSLLQQLLYNE 634

  Fly   475 NLDQEW-DKVLQMLCSTAANHFKPEHCSNDLMDIRNYVNFKKVPGGRRKDSKIVHGVAFSKNVAH 538
            :|...| |.::|::|..... .:|:..::|.||||.:|:.||:|||::.||.:|:|...:||:||
 Frog   635 SLSLSWKDIIVQLVCQVVQT-VRPDVKNDDDMDIRQFVHIKKIPGGKKFDSMVVNGFVCTKNIAH 698

  Fly   539 KDMATHVPFPRILLLQCPIVY-ERIEGKFVTIETVLLQEKEYLRNVCARIMSFKPNVVLVHKNVA 602
            |.|...:..|:||||:|.|.| .|.|.||..|:.::|||:|:|:|...||:..:|.:|||.|.|:
 Frog   699 KKMNASIKTPKILLLKCSIEYLYREETKFTCIDPIVLQEREFLKNYVQRIVDVRPTLVLVEKTVS 763

  Fly   603 GIAQDLLRSYEVTLVLDVKLSVMERLSRTLQCDIVSSIESNITMPKLGYCNDFYIRNY-----NG 662
            .||||:|..:.:|||::||..|::::.|..|.|:|.|::..:|.|:||.|..||::.:     ..
 Frog   764 RIAQDMLLEHGITLVINVKPQVLDQVCRMTQGDLVMSMDQLLTKPRLGTCQKFYMQVFPLPKNEA 828

  Fly   663 KTLMFFEKLTNPRGYTCLLRGGSNAELTRVKRVASALLFARYNWRLEMSFLLNEFAQPLS-PKPS 726
            |||||||......|.|..|||.|..||:|||.:...|::|.|:.:||:|||::|||.|.: ||.|
 Frog   829 KTLMFFEGCPQHLGCTIQLRGASEYELSRVKEIIIFLVYAAYHSQLEISFLMDEFAMPPTLPKSS 893

  Fly   727 -----------------IFDSKETS----------PKTETEAELRSKRPI------ILERKS--- 755
                             :|:.:|.|          .:....:|.:|...|      .||.||
 Frog   894 SFHTLIEGQGEENGHTDLFNGEECSIIHWESDLSLERLHMPSESKSSDDIDFDEASDLETKSLGG 958

  Fly   756 ---------------------------------------EDKITT--------IVSENVSDFTDP 773
                                                   :|::.|        ..:.|:..|.||
 Frog   959 HSSVPHQDPSVMMSSSVQSSGGSVETKIMNQICHIPGITKDEVVTQQETESLQETTSNIKPFRDP 1023

  Fly   774 LRASQA-----EALSTSPCAPPVVEALAVEPRYDNRFRTALSSTLLSVSPFLTFPLPYLETEQGR 833
            |:....     |..||.       :.|.|   :...||..|...:|..||.:||..|:|.:|:|.
 Frog  1024 LQDDTGLYITEEVTSTD-------DRLKV---HSLSFRQELKDVILCSSPIITFKEPFLLSEKGM 1078

  Fly   834 KCKLRKLFPAELYFS----------KQWSRTGLERPDSMGDGEAGKSEPGNKENQMQLLPAHDFV 888
            :|..|..||.::|.|          :...:..|.|..|...|..|.:.    ...:::.|:|:.:
 Frog  1079 RCPTRDYFPDQVYMSPLLNKEVKEMESRRKKQLLRELSSIQGINGTAH----SKAIEIFPSHELL 1139

  Fly   889 LMKITAP-ASSRDIQSKLAEFRSFGGRL-PKGKAPMLRPKKKNAEVIQRPQKVSEEQLYK----- 946
            ..:|:.. ..|:|:...||::|:.|||: .|...|....|.....:..:.:..||....|
 Frog  1140 SKRISEHLGDSQDLARILADYRARGGRIRQKDTDPFFHTKDVTNGLTSKNENKSESDEEKSLTDM 1204

  Fly   947 ------DALDPQNHQRLPVLFCSFHYNPKGVSSFCKLPMLLDMKFYGQYDIMLEQFLQRYCCLFN 1005
                  |.|:..|||||.|||.|.........|:|..|.::.|:|||:.|:.|..||:|||...:
 Frog  1205 SWNSKIDCLNIINHQRLCVLFSSSSAQSNNAPSYCVSPWIVTMEFYGKNDLTLGVFLERYCFRPS 1269

  Fly  1006 SMCPS--CNLPMLGHVRRYVHSLGCVHVYLTEDLTRSDP---TRIYFTSWCSICNATTPTIPLSD 1065
            ..|||  |:.||:.|:||:||..|||.:.|.| |....|   ..|...|||.||...||.:|||:
 Frog  1270 YQCPSVFCDTPMVHHIRRFVHGNGCVQIVLKE-LDSPVPGYQHTILTYSWCRICQQATPVVPLSN 1333

  Fly  1066 AAKCLSLAKYLEMRFHGHAYKRRPPSTDAEQGGTVCEHSLHRDYVHHFSFRGVGAKFQYTPVEVW 1130
            .:..:|.|||||:||:|:.|.||   .:||.    |.||:|.:|..:||:..:.|.|.|:|:.:.
 Frog  1334 DSWSMSFAKYLELRFYGYQYTRR---ANAEP----CGHSIHHNYHQYFSYNQMVASFSYSPIRLL 1391

  Fly  1131 ETDLPSLTVQLDLPQPFQSAQVQEEIKNFSIKGHEVYNRIHERIADLATEEENSPLVQHLKTMLT 1195
            |..:|:..:.:....| ....:.:::|:||.|..:||..:.:|:..|.|:..:....:.::.:..
 Frog  1392 EVCVPTPKIHIKHHSP-AKVSILQDLKDFSQKVTQVYLAVDDRLTSLKTDTFSRTREEKMEDLFA 1455

  Fly  1196 H---DQFIFKQKIEIVHT-LLTDNRATAYDTS---DALAMARRALAESIELWGPRLQEI---EKL 1250
            .   ::..|:..||.:.. ||:.|..|.....   :::...:::|.|.::.|..|||::   ||.
 Frog  1456 QKEMEEVEFRNWIEKLQARLLSSNMDTEQQLQSIFESMIAKKQSLCEMLQAWNNRLQDLFQQEKG 1520

  Fly  1251 TAKQAHHIDSGTI--------CTEELRP------------EQVQTADSSKVTTSSLPKENDPLEC 1295
            ..:.:.....|.:        |..:..|            ::..|..|...|.||..:...|.:.
 Frog  1521 RKRPSVPASPGRMRQGEENKGCASDASPRNSSPAQNGEREDRFMTTLSQSSTGSSHLQIPSPPDL 1585

  Fly  1296 PSEDTETG--ASNSQTVLDKNFSID-----QMLASTVNVYSDKKSIRKILTQLLPSGNQVNPLQS 1353
            .|:.:..|  .:.|.|.:|...|.:     .:|.||.:...:|.:::.|...||| ||..||:..
 Frog  1586 ASDQSFAGTFTALSATEMDTTSSCEDVFDGHLLGSTDSQVKEKSTMKTIFANLLP-GNSYNPILP 1649

  Fly  1354 PF-PAQDHLTLPLGSIPIHVRETDLSSVIAYSLTSMDYQKAIDEAEANSNAAHSSP-----QLKR 1412
            || |.:.:|......:||.|.|.:.||:||::|:..:|:.|:||....::.:.|..     .|..
 Frog  1650 PFDPDKHYLMYEHERVPIAVCEKEPSSIIAFALSCKEYKNALDELSKTASKSCSEECALPVNLVD 1714

  Fly  1413 KIPLAESVSDAEDSPSLSRTSSNTSAAPNASVPSPATAAS------------------------- 1452
            ..|...|.|.|.|:.|:   .||....|.:....|:...|
 Frog  1715 SRPKTSSPSRASDASSV---QSNRPTEPESQSKKPSGVLSFFRGTGGKSPDLSAQRKETLRGADS 1776

  Fly  1453 -------ESEEKSKERIKQPP--------------SPHITLAFQDHSCQFQCKIYFAREFDAMRS 1496
                   ..:|.::.:..:|.              :||:.|.|.|.:.:|.|:||:|.||..||.
 Frog  1777 AYYQVGQTGKEGAESQATEPQDDVDGVDKQKKAFGNPHVELQFSDANAKFYCRIYYAGEFHRMRK 1841

  Fly  1497 KSLKPPKLDKSLYRRLEKSKMREELRISQSRTGSEMELVRKPSDVGAPRTTEDDSNQEEDARIAL 1561
            ..|                             ||                :|||          .
 Frog  1842 VIL-----------------------------GS----------------SEDD----------F 1851

  Fly  1562 ARSLCKSVQWEARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLL 1626
            .|||...|.|:|||||||:.|..|.||||:||:|...::..|..|||.||.||....|.::||.|
 Frog  1852 IRSLAHCVPWQARGGKSGAAFYATEDDRFILKQMPRLEVQSFLDFAPHYFTYIINAVQMKRPTAL 1916

  Fly  1627 AKIFGVFRVSVKKKDSFVER--SVMVMENLFYGCNIENKFDLKGSERNRLV--DPSNQQGEIVLL 1687
            |||.||:|:..|...:..|:  .::||||||||..:...||||||.|||.|  |...:..::|||
 Frog  1917 AKILGVYRIGYKNSQNNTEKKLDLLVMENLFYGRKMAQVFDLKGSLRNRNVKTDTGKESCDVVLL 1981

  Fly  1688 DENLVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGLDKKNGVLVLGIIDYIRT 1752
            ||||::|....|||:.||.|:|||.:|..||.||..:|::|||||||.|.....||:||||||||
 Frog  1982 DENLLKMVRDNPLYIRSHCKSVLRASIHSDSHFLSSHLIIDYSLLVGRDDTTDELVVGIIDYIRT 2046

  Fly  1753 FTLDKRVESIIKGSGILGGKGKDPTVVNPERYKQRFIDAMDRYFLTVPDRWEGL 1806
            ||.||::|.::|.:|||||:||.||||:||.|:.||.:|||:|||.|||.|.||
 Frog  2047 FTWDKKLEMVVKSTGILGGQGKMPTVVSPELYRTRFCEAMDKYFLMVPDHWTGL 2100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264	42/60 (70%)
		DEP	329..397	CDD:214489	21/148 (14%)
		Fab1_TCP	464..717	CDD:239450	107/259 (41%)
		PIPKc_PIKfyve	1479..1796	CDD:340437	141/320 (44%)
pikfyve	NP_001362234.2	FYVE_PIKfyve_Fab1	160..221	CDD:277264	42/60 (70%)
		DEP_PIKfyve	363..444	CDD:239895	16/82 (20%)
		Fab1_TCP	624..883	CDD:239450	107/259 (41%)
		PIPKc_PIKfyve	1824..2090	CDD:340437	141/320 (44%)