DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fab1 and pip5k1ab

DIOPT Version :9

Sequence 1:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	XP_021322354.1	Gene:	pip5k1ab / 492549	ZFINID:	ZDB-GENE-041111-123	Length:	598	Species:	Danio rerio

Alignment Length:	258	Identity:	68/258 - (26%)
Similarity:	108/258 - (41%)	Gaps:	44/258 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1564 SLCKSVQWE-ARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLLA 1627
            |||.....| :..|.|||.|..|.||.|::|.:..::....:...|.||..::    |.:.|||.
Zfish   153 SLCNDPLIELSNPGASGSIFYVTSDDEFIIKTVMHKEAEFLQKLLPGYFMNLN----QNKRTLLP 213

  Fly  1628 KIFGVFRVSVKKKDSFVERSVMVMENLF-YGCNIENKFDLKGSERNRLVDPSNQQGEI-VLLDEN 1690
            |.:|::.|....|:.    .::||.||. ....:..|:|||||...|...|..:...: ...|.:
Zfish   214 KFYGLYCVQAGGKNI----RIVVMNNLLPRSVPMHLKYDLKGSTYKRRASPKERDKSVPTYKDLD 274

  Fly  1691 LVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGLDKKNGVLVLGIIDYIRTFTL 1755
            .:| ...:.:.:...:...|...||||...|:...:||||||||               :....|
Zfish   275 FIQ-DMPEGIQLEPDNYNALCKTIQRDCLLLQSFKIMDYSLLVG---------------VHNTDL 323

  Fly  1756 DKRVESIIKGSGILGGKGKDPTVV----NPERYKQRFIDAMD--------RYFLTVPDRWEGL 1806
            ..|     :.:|::.|.|.:.||.    .|:..|..:..||:        :..|...|:|.|:
Zfish   324 ASR-----ERAGVVEGGGSEGTVTPDHRRPQIQKALYSTAMESIQGEAKGKGTLETEDQWGGI 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264
		DEP	329..397	CDD:214489
		Fab1_TCP	464..717	CDD:239450
		PIPKc	1413..1797	CDD:295374	64/247 (26%)
pip5k1ab	XP_021322354.1	PIPKc	98..444	CDD:214623	68/258 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810