DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fab1 and CCT4

DIOPT Version :9

Sequence 1:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	NP_609579.1	Gene:	CCT4 / 34674	FlyBaseID:	FBgn0032444	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	118/526 - (22%)
Similarity:	195/526 - (37%)	Gaps:	146/526 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 DDRKNILQQSNSLITLHEEMQRDLPAQNCGQRLIEFLNSNNKSANE--VQAVAILNAMLAAGFLE 378
            :|...||:|.|   .||       ||   .:.|:|...:.:.:|.:  ...|.|..|:|.|  .|
  Fly    65 NDGATILKQMN---VLH-------PA---AKMLVELSRAQDVAAGDGTTSVVVIAGALLEA--CE 114

  Fly   379 PIVPDPEQMDFDSSLHYKFSKSSSSDTSRTMSPQFEANPHAEPQPPKSMDQSAEEKEKELENELE 443
            .::        ...||    .::.||:.:..|                  ..|.|..|::...:|
  Fly   115 KLL--------QKGLH----PTAISDSFQRCS------------------NKAVEILKQMSTPIE 149

  Fly   444 NDRCYT---TATSKLLASYCEHEEQLLAQMLRAHNLDQEWDKVLQMLCSTAANHFKP-EHCSNDL 504
            .|...|   :|::.|.:.....:..|||.:        ..|.||::.        .| :..|.||
  Fly   150 LDDRETLIKSASTSLNSKVVSQQSSLLAPI--------AVDAVLKVT--------DPGKETSVDL 198

  Fly   505 MDIRNYVNFKKVPGGRRKDSKIVHGVAFSKNVAHKDMATHVPFPRILLLQCPIV-------YERI 562
            .:|:...:.    ||..:|:::|.|:.|:...|..:....:...:|.|:|..|.       :..|
  Fly   199 KNIKVISSL----GGTVEDTELVDGLVFTCRSAGSNAPKRIEKAKIGLIQFCISAPKTDMDHNVI 259

  Fly   563 EGKFVTIETVLLQEKEYLRNVCARIMSFKPNVVLVHKN-----VAGIAQDLLRSYEVTLVLDVKL 622
            ...:..::.||.:|:.|:.|:..:|.....||:||.|:     |:.:||..|...:..:|.||:.
  Fly   260 VSDYAAMDRVLKEERSYILNIVKQIKKSGCNVLLVQKSILRDAVSDLAQHFLDKIKCMVVKDVER 324

  Fly   623 SVMERLSRTLQCDIVSSIESNITMPKLGYCNDFYIRNYNGKTLM--------FFEKLTN----PR 675
            ..:|.:.:||.|..::|::            .|...|.:...|:        .|.|:|.    .|
  Fly   325 EDIEFVCKTLHCRPIASLD------------HFTAENLSSADLVEEVASGTNKFVKITGIQNMGR 377

  Fly   676 GYTCLLRGGSNAELTRVKR-VASALLFARYNWRL------------EMSFLLNEFAQPLSPKP-- 725
            ..:.:.||.:...|....| :..||...|...:|            ||:..|...||.:....
  Fly   378 TVSIICRGSNKLVLEEAARSLHDALCVVRCLVKLRAQIVGGGAPEIEMALQLAALAQTVEGVDAY 442

  Fly   726 ---SIFDSKETSPKT----------ETEAELRS------KRPIILERKSEDKITTIVSENVSDFT 771
               :..|:.|..|.|          .|..|||:      |...|..||.  .||.|.:|||   .
  Fly   443 CFRAFADALEVIPSTLAENAGLNPIATVTELRNRHAQGEKNAGINVRKG--AITDIFAENV---V 502

  Fly   772 DPLRAS 777
            .||..|
  Fly   503 QPLLVS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264
		DEP	329..397	CDD:214489	15/69 (22%)
		Fab1_TCP	464..717	CDD:239450	64/290 (22%)
		PIPKc	1413..1797	CDD:295374
CCT4	NP_609579.1	TCP1_delta	18..531	CDD:239454	118/526 (22%)
CCT4	NP_609579.1	Cpn60_TCP1	37..529	CDD:278544	118/526 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453416
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930