Protein Alignment fab1 and pikfyve

DIOPT Version :10

• Sequence 1: NP_611269.1
• Gene: fab1 / 37033
• FlyBaseID: FBgn0028741
• Length: 1809
• Species: Drosophila melanogaster
• Sequence 2: XP_009302997.1
• Gene: pikfyve / 337690
• ZFINID: ZDB-GENE-030131-9636
• Length: 2117
• Species: Danio rerio
• Alignment Length: 2242
• Identity: 669/2242 - (29%)
• Similarity: 985/2242 - (43%)
• Gaps: 606/2242 - (27%)

  Fly    17 SPSKLTEF--ARNFEDKP--ESLFGRVVNKIQNVYNQSYNTVNDISSGS-SSSSSTQPVQVVGKS 76
            |||.||.|  ....:|:|  .|.:...|:..:  :|:.....|...:.. :.....:|..|..||
Zfish    26 SPSHLTHFKPLTPEQDEPPLRSAYSSFVSLFR--FNKEKTGANIAPAKKLAKLEEGRPPSVTEKS 88

  Fly    77 QFFSDSQTSTAEIADVETSSQSSVRPQPPTTLSIRTNSETRGTSTSSNTAAEDSETSDRVETLPL 141
            |..|.|                   ||.|           |...:|.:.:...|||..:...|..
Zfish    89 QSASSS-------------------PQGP-----------RRNWSSPSHSIHGSETHRKHPELLR 123

  Fly   142 PTSEANQGRTVS----------------NVLKHISNIVATKNNNDLRNYKDTELQRFWMPDSKAK 190
            .||.|::||..|                ..||.:..|:..|:       :|::|:::|||||:.|
Zfish   124 RTSAASEGRRKSEAPLGSHDPRTAVQLRTALKRLKEIMEGKS-------QDSDLKQYWMPDSQCK 181

  Fly   191 ECYDCSQKFSTFRRKHHCRLCGQIFCSKCCNQVVPGMIIRCDGDLKVCNYCSKIVLTFLKSS-SS 254
            |||||::||:||||:||||||||||||:||||.:||..:...|||:.|.||.||.|::..|: ||
Zfish   182 ECYDCNEKFTTFRRRHHCRLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSS 246

  Fly   255 EMGQDMQELQQHLSNKLEVQDSGSSL-AKHPQMQRAPL-----------------PRKTSVG--- 298
            .:|:|:..|          .||..|: ...|...|.|:                 .||.|:|
Zfish   247 SIGEDLSAL----------SDSPCSVCVLEPTEPRTPVGGRKASRNIFLEEDLAWQRKNSIGMRK 301

  Fly   299 -YQEERFSS--------------------HPTYTTLSID-------------------------- 316
             :||.:.|.                    ..:.|.||:|
Zfish   302 NHQESQNSGLNSRLTVVQEDIGKSPARKRSASVTNLSLDRSGSSMVPAYESSVSPQNSRALPKTD 366

  Fly   317 ---DRKNILQQSNSLITL---------------HEEMQRDLPAQNC--GQRLIEFLNSNNKSANE 361
               :.:.||..|..|..:               |....|..|  ||  |:.|:.:|..|...:..
Zfish   367 HSEEERKILLDSFQLKDIWKKICHNTTGMEFQDHRYWLRTYP--NCIVGKELVNWLLRNGTISTR 429

  Fly   362 VQAVAILNAMLAAGFLEPI------------------------VPDPEQMDFDSSLH-------- 394
            .||:||..|::...:|:.:                        .|.|:. |..:||.
Zfish   430 AQAIAIGQALVDGRWLDCVTHHDQIFRDEYALYRPLQSTEFSETPSPDS-DSVNSLEGHSEPSWF 493

  Fly   395 --YKF---------------SKSSSSDTSRTMSPQFEA--------------------------- 415
              .||               :.||||.:.||....|.:
Zfish   494 KDIKFDDSDTEQLADENDYVTPSSSSPSKRTSVSSFHSAVDSDSAASISLNMEQDNVNFHIKKQA 558

  Fly   416 -NPHAEPQP--PKSMD----------------------------------------QSAEEKEKE 437
             .||..|.|  .|||:                                        :..|||.||
Zfish   559 KYPHVPPYPAEQKSMEPHDPFTPETDIHAPMEVLLSEDGGQHISISDAFIKESLFNRRVEEKAKE 623

  Fly   438 L-----------ENELENDRCYTTATSKLLASYCEHEEQLLAQMLRAHNLDQEWDKVLQMLCSTA 491
            :           .::|..:.....|..:||::...|...||.|:|.:.:|...|..::..:....
Zfish   624 MLFTPLGWHHSSLDQLREENGEKKAMERLLSANHSHMMALLQQLLYSESLSLSWRDIIVPVVRQV 688

  Fly   492 ANHFKPE--HCSNDLMDIRNYVNFKKVPGGRRKDSKIVHGVAFSKNVAHKDMATHVPFPRILLLQ 554
            ....:|:  .|.:| ||||.:|:.||:|||::.||.:|:|...:||:|||.|.:::..|:||||:
Zfish   689 VQTVRPDVRSCDDD-MDIRQFVHIKKIPGGKKFDSAVVNGFVCTKNIAHKKMNSYIKNPKILLLK 752

  Fly   555 CPIVY-ERIEGKFVTIETVLLQEKEYLRNVCARIMSFKPNVVLVHKNVAGIAQDLLRSYEVTLVL 618
            |.|.| .|.|.||..|:.::|||:|:|:|...||:..:||:|||.|.|:.||||:|..:.:.:|:
Zfish   753 CSIEYLYREETKFTCIDPIVLQEREFLKNYVQRIVDVRPNLVLVEKTVSRIAQDMLLEHGIAIVI 817

  Fly   619 DVKLSVMERLSRTLQCDIVSSIESNITMPKLGYCNDFYIR-----NYNGKTLMFFEKLTNPRGYT 678
            :||..|::|:||..|.|:|.|::..:|.|:||.|:.||:.     |...|||||||......|.|
Zfish   818 NVKPQVLDRVSRMTQGDLVISMDQLLTKPRLGTCHKFYLHSFQLPNSEVKTLMFFEGCPPQLGCT 882

  Fly   679 CLLRGGSNAELTRVKRVASALLFARYNWRLEMSFLLNEFAQPLSPKPSIFDSK------------ 731
            ..|||.|..||.|||.:...::...|:.:||:|||::|||.|    ||:.:|.
Zfish   883 IKLRGASEYELARVKEIIIFMVCVAYHSQLEISFLMDEFAMP----PSLAESSSFPCLLESTTLR 943

  Fly   732 ---ETSPKTETE---------------------------AELRSKRPIILERKSED--------- 757
               |||.:.|::                           .:..|:.|...|...:|
Zfish   944 EEDETSGERESQDNDESTLGDDNLTLVPGDDFETGFTGTIKAHSREPSTSESSHKDGESPRINKN 1008

  Fly   758 --------------KITTIVSENVSDFTDPL----------RASQ-------------------- 778
                          |.:|.:|...|.|..|:          ..||
Zfish  1009 ASITSFSGGEEENIKTSTPLSSFSSTFPQPVTPPFLISDVKEMSQEVVKGSGEGEKNKYLESTLV 1073

  Fly   779 -AEALSTSPCAPP---------------VVEALAVEPRYDNR-------FRTALSSTLLSVSPFL 820
             .::.|:....||               |.|.:|..   |:|       |:..|...:|.:|||:
Zfish  1074 HQDSTSSETSLPPTRLFRDPLQDDTGLFVTEHVASS---DDRLKSISALFKQELKDIILCISPFI 1135

  Fly   821 TFPLPYLETEQGRKCKLRKLFPAELYFSKQWSRTGLERPDSMGDGEAGK-----SEPG------- 873
            ||..|:|.|..|.:|..|..||.::|.|...::...|.     ||...:     |.||
Zfish  1136 TFREPFLLTPAGLRCPSRDYFPEQVYLSPLLNKDSKEL-----DGRRKRQLLKESSPGSGSLTNG 1195

  Fly   874 --NKENQMQLLPAHDFVLMKITAP-ASSRDIQSKLAEFRSFGGRL-----------PKGKAPMLR 924
              :.:..:|:||.|.....:|... .||:.:...||::|:.|||:           |..|||:..
Zfish  1196 SVSHQRAIQILPCHKLTSARIAEQVGSSQQLARMLADYRAQGGRIRQREGTQFREAPPPKAPIKA 1260

  Fly   925 PKK--KNAEVIQRPQKVSEEQLYKDALDPQNHQRLPVLFCSFHYNPKGVSSFCKLPMLLDMKFYG 987
            ..:  |.|.||.......     .|.|:|.|||||.|||.|.........:.|..|.::.|:|||
Zfish  1261 DSEEDKGAGVIDMTWSTK-----LDCLNPINHQRLCVLFSSSSAQSNNAPNPCVSPWIVTMEFYG 1320

  Fly   988 QYDIMLEQFLQRYCCLFNSMCPS--CNLPMLGHVRRYVHSLGCVHVYLTEDLTRSDP---TRIYF 1047
            :.|:.|..||:|||...:..|||  |..||:.|:||:||..|||.:.|.| |....|   ..|..
Zfish  1321 KNDLTLGVFLERYCFRPSYQCPSMYCETPMVHHIRRFVHGKGCVQIVLKE-LDSPVPGYQHTILN 1384

  Fly  1048 TSWCSICNATTPTIPLSDAAKCLSLAKYLEMRFHGHAYKRRPPSTDAEQGGTVCEHSLHRDYVHH 1112
            .|||.||...||.:|||:.:..:|.|||||:||:||.|.||   .:||.    |.||:|:||..:
Zfish  1385 YSWCRICKQVTPVVPLSNDSWSMSFAKYLELRFYGHQYTRR---ANAEP----CGHSIHKDYHQY 1442

  Fly  1113 FSFRGVGAKFQYTPVEVWETDLPSLTVQLDLPQPFQSAQVQEEIKNFSIKGHEVYNRIHERIADL 1177
            ||:..:.|.|.|.||.:.|..||...:.:....|.:|: :|:::|:||.|..:||..|.:|:..|
Zfish  1443 FSYNQMVASFSYIPVRLLEICLPPPKIIIRNQGPSKSS-LQQDLKDFSQKVAQVYLAIDDRLTSL 1506

  Fly  1178 ATEEENSPLVQHLKTMLTHDQFIFK-----------QKIEI-VHTLLTDNRATAYDTSDALAMAR 1230
            .|:..:....:.::     |.|..|           :|::: :.|.:.|:........:::.:.:
Zfish  1507 KTDTFSKTREEKME-----DMFAQKDMEESELRGWIEKLQVRLQTSVIDSSQQLQAVLESVVVKK 1566

  Fly  1231 RALAESIELWGPRLQEI-------EKLTA-------KQAHHIDSGTICTE-------------EL 1268
            :.|.|:::.|..||||:       ::|:.       :|....:|.|...|             :.
Zfish  1567 QGLCETLQSWNNRLQELFQQEKGRKRLSVPPSPGRHRQPTTDESKTSALESSPRNPSPVVPNGDK 1631

  Fly  1269 RPEQVQTADSSKVTTSSLPKENDPLECPSEDTETG--------ASNSQTVLDKNFSIDQMLASTV 1325
            ....:.|..||. .:|||.:...|.|.||:...:|        .||.:.:.|     ..:|.|..
Zfish  1632 EDRHLNTFPSSS-GSSSLLQLPSPAEQPSDVITSGPSFPDQDSVSNPEDMFD-----GHLLGSND 1690

  Fly  1326 NVYSDKKSIRKILTQLLPSGNQVNPLQSPF-PAQDHLTLPLGSIPIHVRETDLSSVIAYSLTSMD 1389
            :...:|.:::.||..||| ||..||:..|| |.:.:|......:||.|.|.:.||:||::|:..:
Zfish  1691 SQVKEKSTMKTILANLLP-GNSYNPIPFPFDPDKHYLMYEHERVPIAVCEREPSSIIAFALSCKE 1754

  Fly  1390 YQKAIDEAEANSNAAHSSPQLKRKIPLAES-VSDAEDSPSLSRTSSNTSAAPNASVPSPATAASE 1453
            |:.|::|. ..:.|........:.|...|| |.::...||    .::.|....:||.:......|
Zfish  1755 YKTALEEL-TKTTAKTGGDDTSQTISAGESRVKNSPAKPS----DNSMSQLSRSSVDADPLKEPE 1814

  Fly  1454 SEEKSKERIKQPPSPHITLAFQDHSCQFQCKIYFAREFDAMRSKSLKPPKLDKSLYRRLEKSKMR 1518
            |.:|.|   ||..:|||.|.|.|.:.:|.|:||:|.||                       .|||
Zfish  1815 SADKQK---KQTGNPHIELQFSDANAKFYCRIYYAEEF-----------------------HKMR 1853

  Fly  1519 EELRISQSRTGSEMELVRKPSDVGAPRTTEDDSNQEEDARIALARSLCKSVQWEARGGKSGSRFC 1583
            ||:          ||            :||||          ..|||...|.|:|||||||:.|.
Zfish  1854 EEI----------ME------------STEDD----------FVRSLSHCVNWQARGGKSGAVFY 1886

  Fly  1584 KTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLLAKIFGVFRVSVKKKDSFVER-- 1646
            .|.||||:||:|...::..|..|||.||.||......::||.||||.||:|:..|...:..|:
Zfish  1887 ATEDDRFILKQMPRLEVQSFLDFAPHYFTYITGAVHLKRPTALAKILGVYRIGYKNSQNNTEKKL 1951

  Fly  1647 SVMVMENLFYGCNIENKFDLKGSERNRLV--DPSNQQGEIVLLDENLVQMSWSKPLYVLSHSKTV 1709
            .::||||||||..:...||||||.|||.|  |...:..|:|||||||:::....|||:.||.|.:
Zfish  1952 DLLVMENLFYGRKMAQVFDLKGSLRNRNVKTDQGKESCEVVLLDENLLKLVHDNPLYIRSHCKAI 2016

  Fly  1710 LRDAIQRDSSFLEKNLVMDYSLLVGLDKKNGVLVLGIIDYIRTFTLDKRVESIIKGSGILGGKGK 1774
            ||.||..|:.||..:|::|||||||.|.....||:||||||||||.||::|.::|.:|||||:||
Zfish  2017 LRAAIHSDALFLSSHLIIDYSLLVGRDDSTDELVVGIIDYIRTFTWDKKLEMVVKSTGILGGQGK 2081

  Fly  1775 DPTVVNPERYKQRFIDAMDRYFLTVPDRWEGL 1806
            .||||:||.|:.||.:|||:|||.|||.|.||
Zfish  2082 MPTVVSPELYRTRFCEAMDKYFLMVPDHWSGL 2113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264	41/60 (68%)
		DEP	329..397	CDD:214489	20/118 (17%)
		Fab1_TCP	464..717	CDD:239450	105/260 (40%)
		PIPKc_PIKfyve	1479..1796	CDD:340437	142/320 (44%)
pikfyve	XP_009302997.1	FYVE_PIKfyve_Fab1	173..234	CDD:277264	41/60 (68%)
		DEP_PIKfyve	383..464	CDD:239895	15/82 (18%)
		Fab1_TCP	661..921	CDD:239450	105/260 (40%)
		PIPKc_PIKfyve	1837..2103	CDD:340437	142/320 (44%)