DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fab1 and pikfyve

DIOPT Version :9

Sequence 1:NP_611269.1 Gene:fab1 / 37033 FlyBaseID:FBgn0028741 Length:1809 Species:Drosophila melanogaster
Sequence 2:XP_009302996.1 Gene:pikfyve / 337690 ZFINID:ZDB-GENE-030131-9636 Length:2121 Species:Danio rerio


Alignment Length:2235 Identity:664/2235 - (29%)
Similarity:983/2235 - (43%) Gaps:588/2235 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SPSKLTEF--ARNFEDKP--ESLFGRVVNKIQNVYNQSYNTVNDISSGS-SSSSSTQPVQVVGKS 76
            |||.||.|  ....:|:|  .|.:...|:..:  :|:.....|...:.. :.....:|..|..||
Zfish    26 SPSHLTHFKPLTPEQDEPPLRSAYSSFVSLFR--FNKEKTGANIAPAKKLAKLEEGRPPSVTEKS 88

  Fly    77 QFFSDSQTSTAEIADVETSSQSSVRPQPPTTLSIRTNSETRGTST---------SSNTAAEDSET 132
            |..|.|                   ||.|.......:....|:.|         .::.|:.:.|.
Zfish    89 QSASSS-------------------PQGPRRNWSSPSHSIHGSETHRKHPELLRRTSAASAEWEE 134

  Fly   133 SDRVETLPLPTSEANQGRTVSNVLKHISNIVATKNNNDLRNYKDTELQRFWMPDSKAKECYDCSQ 197
            ..|....||.:.:......:...||.:..|:..|:       :|::|:::|||||:.||||||::
Zfish   135 GRRKSEAPLGSHDPRTAVQLRTALKRLKEIMEGKS-------QDSDLKQYWMPDSQCKECYDCNE 192

  Fly   198 KFSTFRRKHHCRLCGQIFCSKCCNQVVPGMIIRCDGDLKVCNYCSKIVLTFLKSS-SSEMGQDMQ 261
            ||:||||:||||||||||||:||||.:||..:...|||:.|.||.||.|::..|: ||.:|:|:.
Zfish   193 KFTTFRRRHHCRLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSSSIGEDLS 257

  Fly   262 ELQQHLSNKLEVQDSGSSL-AKHPQMQRAPL-----------------PRKTSVG----YQEERF 304
            .|          .||..|: ...|...|.|:                 .||.|:|    :||.:.
Zfish   258 AL----------SDSPCSVCVLEPTEPRTPVGGRKASRNIFLEEDLAWQRKNSIGMRKNHQESQN 312

  Fly   305 SS--------------------HPTYTTLSID-----------------------------DRKN 320
            |.                    ..:.|.||:|                             :.:.
Zfish   313 SGLNSRLTVVQEDIGKSPARKRSASVTNLSLDRSGSSMVPAYESSVSPQNSRALPKTDHSEEERK 377

  Fly   321 ILQQSNSLITL---------------HEEMQRDLPAQNC--GQRLIEFLNSNNKSANEVQAVAIL 368
            ||..|..|..:               |....|..|  ||  |:.|:.:|..|...:...||:||.
Zfish   378 ILLDSFQLKDIWKKICHNTTGMEFQDHRYWLRTYP--NCIVGKELVNWLLRNGTISTRAQAIAIG 440

  Fly   369 NAMLAAGFLEPI------------------------VPDPEQMDFDSSLH----------YKF-- 397
            .|::...:|:.:                        .|.|:. |..:||.          .||  
Zfish   441 QALVDGRWLDCVTHHDQIFRDEYALYRPLQSTEFSETPSPDS-DSVNSLEGHSEPSWFKDIKFDD 504

  Fly   398 -------------SKSSSSDTSRTMSPQFEA----------------------------NPHAEP 421
                         :.||||.:.||....|.:                            .||..|
Zfish   505 SDTEQLADENDYVTPSSSSPSKRTSVSSFHSAVDSDSAASISLNMEQDNVNFHIKKQAKYPHVPP 569

  Fly   422 QP--PKSMD----------------------------------------QSAEEKEKEL------ 438
            .|  .|||:                                        :..|||.||:      
Zfish   570 YPAEQKSMEPHDPFTPETDIHAPMEVLLSEDGGQHISISDAFIKESLFNRRVEEKAKEMLFTPLG 634

  Fly   439 -----ENELENDRCYTTATSKLLASYCEHEEQLLAQMLRAHNLDQEWDKVLQMLCSTAANHFKPE 498
                 .::|..:.....|..:||::...|...||.|:|.:.:|...|..::..:........:|:
Zfish   635 WHHSSLDQLREENGEKKAMERLLSANHSHMMALLQQLLYSESLSLSWRDIIVPVVRQVVQTVRPD 699

  Fly   499 --HCSNDLMDIRNYVNFKKVPGGRRKDSKIVHGVAFSKNVAHKDMATHVPFPRILLLQCPIVY-E 560
              .|.:| ||||.:|:.||:|||::.||.:|:|...:||:|||.|.:::..|:||||:|.|.| .
Zfish   700 VRSCDDD-MDIRQFVHIKKIPGGKKFDSAVVNGFVCTKNIAHKKMNSYIKNPKILLLKCSIEYLY 763

  Fly   561 RIEGKFVTIETVLLQEKEYLRNVCARIMSFKPNVVLVHKNVAGIAQDLLRSYEVTLVLDVKLSVM 625
            |.|.||..|:.::|||:|:|:|...||:..:||:|||.|.|:.||||:|..:.:.:|::||..|:
Zfish   764 REETKFTCIDPIVLQEREFLKNYVQRIVDVRPNLVLVEKTVSRIAQDMLLEHGIAIVINVKPQVL 828

  Fly   626 ERLSRTLQCDIVSSIESNITMPKLGYCNDFYIR-----NYNGKTLMFFEKLTNPRGYTCLLRGGS 685
            :|:||..|.|:|.|::..:|.|:||.|:.||:.     |...|||||||......|.|..|||.|
Zfish   829 DRVSRMTQGDLVISMDQLLTKPRLGTCHKFYLHSFQLPNSEVKTLMFFEGCPPQLGCTIKLRGAS 893

  Fly   686 NAELTRVKRVASALLFARYNWRLEMSFLLNEFAQPLSPKPSIFDSK---------------ETSP 735
            ..||.|||.:...::...|:.:||:|||::|||.|    ||:.:|.               |||.
Zfish   894 EYELARVKEIIIFMVCVAYHSQLEISFLMDEFAMP----PSLAESSSFPCLLESTTLREEDETSG 954

  Fly   736 KTETE---------------------------AELRSKRPIILERKSED---------------- 757
            :.|::                           .:..|:.|...|...:|                
Zfish   955 ERESQDNDESTLGDDNLTLVPGDDFETGFTGTIKAHSREPSTSESSHKDGESPRINKNASITSFS 1019

  Fly   758 -------KITTIVSENVSDFTDPL----------RASQ---------------------AEALST 784
                   |.:|.:|...|.|..|:          ..||                     .::.|:
Zfish  1020 GGEEENIKTSTPLSSFSSTFPQPVTPPFLISDVKEMSQEVVKGSGEGEKNKYLESTLVHQDSTSS 1084

  Fly   785 SPCAPP---------------VVEALAVEPRYDNR-------FRTALSSTLLSVSPFLTFPLPYL 827
            ....||               |.|.:|..   |:|       |:..|...:|.:|||:||..|:|
Zfish  1085 ETSLPPTRLFRDPLQDDTGLFVTEHVASS---DDRLKSISALFKQELKDIILCISPFITFREPFL 1146

  Fly   828 ETEQGRKCKLRKLFPAELYFSKQWSRTGLERPDSMGDGEAGK-----SEPG---------NKENQ 878
            .|..|.:|..|..||.::|.|...::...|.     ||...:     |.||         :.:..
Zfish  1147 LTPAGLRCPSRDYFPEQVYLSPLLNKDSKEL-----DGRRKRQLLKESSPGSGSLTNGSVSHQRA 1206

  Fly   879 MQLLPAHDFVLMKITAP-ASSRDIQSKLAEFRSFGGRL-----------PKGKAPMLRPKK--KN 929
            :|:||.|.....:|... .||:.:...||::|:.|||:           |..|||:....:  |.
Zfish  1207 IQILPCHKLTSARIAEQVGSSQQLARMLADYRAQGGRIRQREGTQFREAPPPKAPIKADSEEDKG 1271

  Fly   930 AEVIQRPQKVSEEQLYKDALDPQNHQRLPVLFCSFHYNPKGVSSFCKLPMLLDMKFYGQYDIMLE 994
            |.||.......     .|.|:|.|||||.|||.|.........:.|..|.::.|:|||:.|:.|.
Zfish  1272 AGVIDMTWSTK-----LDCLNPINHQRLCVLFSSSSAQSNNAPNPCVSPWIVTMEFYGKNDLTLG 1331

  Fly   995 QFLQRYCCLFNSMCPS--CNLPMLGHVRRYVHSLGCVHVYLTEDLTRSDP---TRIYFTSWCSIC 1054
            .||:|||...:..|||  |..||:.|:||:||..|||.:.|.| |....|   ..|...|||.||
Zfish  1332 VFLERYCFRPSYQCPSMYCETPMVHHIRRFVHGKGCVQIVLKE-LDSPVPGYQHTILNYSWCRIC 1395

  Fly  1055 NATTPTIPLSDAAKCLSLAKYLEMRFHGHAYKRRPPSTDAEQGGTVCEHSLHRDYVHHFSFRGVG 1119
            ...||.:|||:.:..:|.|||||:||:||.|.||   .:||.    |.||:|:||..:||:..:.
Zfish  1396 KQVTPVVPLSNDSWSMSFAKYLELRFYGHQYTRR---ANAEP----CGHSIHKDYHQYFSYNQMV 1453

  Fly  1120 AKFQYTPVEVWETDLPSLTVQLDLPQPFQSAQVQEEIKNFSIKGHEVYNRIHERIADLATEEENS 1184
            |.|.|.||.:.|..||...:.:....|.:|: :|:::|:||.|..:||..|.:|:..|.|:..:.
Zfish  1454 ASFSYIPVRLLEICLPPPKIIIRNQGPSKSS-LQQDLKDFSQKVAQVYLAIDDRLTSLKTDTFSK 1517

  Fly  1185 PLVQHLKTMLTHDQFIFK-----------QKIEI-VHTLLTDNRATAYDTSDALAMARRALAESI 1237
            ...:.::     |.|..|           :|::: :.|.:.|:........:::.:.::.|.|::
Zfish  1518 TREEKME-----DMFAQKDMEESELRGWIEKLQVRLQTSVIDSSQQLQAVLESVVVKKQGLCETL 1577

  Fly  1238 ELWGPRLQEI-------EKLTA-------KQAHHIDSGTICTE-------------ELRPEQVQT 1275
            :.|..||||:       ::|:.       :|....:|.|...|             :.....:.|
Zfish  1578 QSWNNRLQELFQQEKGRKRLSVPPSPGRHRQPTTDESKTSALESSPRNPSPVVPNGDKEDRHLNT 1642

  Fly  1276 ADSSKVTTSSLPKENDPLECPSEDTETG--------ASNSQTVLDKNFSIDQMLASTVNVYSDKK 1332
            ..||. .:|||.:...|.|.||:...:|        .||.:.:.|     ..:|.|..:...:|.
Zfish  1643 FPSSS-GSSSLLQLPSPAEQPSDVITSGPSFPDQDSVSNPEDMFD-----GHLLGSNDSQVKEKS 1701

  Fly  1333 SIRKILTQLLPSGNQVNPLQSPF-PAQDHLTLPLGSIPIHVRETDLSSVIAYSLTSMDYQKAIDE 1396
            :::.||..||| ||..||:..|| |.:.:|......:||.|.|.:.||:||::|:..:|:.|::|
Zfish  1702 TMKTILANLLP-GNSYNPIPFPFDPDKHYLMYEHERVPIAVCEREPSSIIAFALSCKEYKTALEE 1765

  Fly  1397 AEANSNAAHSSPQLKRKIPLAES-VSDAEDSPSLSRTSSNTSAAPNASVPSPATAASESEEKSKE 1460
            . ..:.|........:.|...|| |.::...||    .::.|....:||.:......||.:|.| 
Zfish  1766 L-TKTTAKTGGDDTSQTISAGESRVKNSPAKPS----DNSMSQLSRSSVDADPLKEPESADKQK- 1824

  Fly  1461 RIKQPPSPHITLAFQDHSCQFQCKIYFAREFDAMRSKSLKPPKLDKSLYRRLEKSKMREELRISQ 1525
              ||..:|||.|.|.|.:.:|.|:||:|.||                       .|||||:    
Zfish  1825 --KQTGNPHIELQFSDANAKFYCRIYYAEEF-----------------------HKMREEI---- 1860

  Fly  1526 SRTGSEMELVRKPSDVGAPRTTEDDSNQEEDARIALARSLCKSVQWEARGGKSGSRFCKTLDDRF 1590
                  ||            :||||          ..|||...|.|:|||||||:.|..|.||||
Zfish  1861 ------ME------------STEDD----------FVRSLSHCVNWQARGGKSGAVFYATEDDRF 1897

  Fly  1591 VLKEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLLAKIFGVFRVSVKKKDSFVER--SVMVMEN 1653
            :||:|...::..|..|||.||.||......::||.||||.||:|:..|...:..|:  .::||||
Zfish  1898 ILKQMPRLEVQSFLDFAPHYFTYITGAVHLKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVMEN 1962

  Fly  1654 LFYGCNIENKFDLKGSERNRLV--DPSNQQGEIVLLDENLVQMSWSKPLYVLSHSKTVLRDAIQR 1716
            ||||..:...||||||.|||.|  |...:..|:|||||||:::....|||:.||.|.:||.||..
Zfish  1963 LFYGRKMAQVFDLKGSLRNRNVKTDQGKESCEVVLLDENLLKLVHDNPLYIRSHCKAILRAAIHS 2027

  Fly  1717 DSSFLEKNLVMDYSLLVGLDKKNGVLVLGIIDYIRTFTLDKRVESIIKGSGILGGKGKDPTVVNP 1781
            |:.||..:|::|||||||.|.....||:||||||||||.||::|.::|.:|||||:||.||||:|
Zfish  2028 DALFLSSHLIIDYSLLVGRDDSTDELVVGIIDYIRTFTWDKKLEMVVKSTGILGGQGKMPTVVSP 2092

  Fly  1782 ERYKQRFIDAMDRYFLTVPDRWEGL 1806
            |.|:.||.:|||:|||.|||.|.||
Zfish  2093 ELYRTRFCEAMDKYFLMVPDHWSGL 2117

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fab1NP_611269.1 FYVE_PIKfyve_Fab1 182..243 CDD:277264 41/60 (68%)
DEP 329..397 CDD:214489 20/118 (17%)
Fab1_TCP 464..717 CDD:239450 105/260 (40%)
PIPKc 1413..1797 CDD:295374 164/388 (42%)
pikfyveXP_009302996.1 FYVE_PIKfyve_Fab1 177..238 CDD:277264 41/60 (68%)
DEP_PIKfyve 387..468 CDD:239895 15/82 (18%)
Fab1_TCP 665..925 CDD:239450 105/260 (40%)
PIPKc 1814..2108 CDD:238081 155/351 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170578368
Domainoid 1 1.000 296 1.000 Domainoid score I1453
eggNOG 1 0.900 - - E1_COG5253
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H32115
Inparanoid 1 1.050 604 1.000 Inparanoid score I902
OMA 1 1.010 - - QHG58433
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003143
OrthoInspector 1 1.000 - - oto41021
orthoMCL 1 0.900 - - OOG6_101979
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2108
SonicParanoid 1 1.000 - - X2110
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 1 1.500 - -
1515.190

Return to query results.
Submit another query.