Protein Alignment fab1 and Hrs

DIOPT Version :10

• Sequence 1: NP_611269.1
• Gene: fab1 / 37033
• FlyBaseID: FBgn0028741
• Length: 1809
• Species: Drosophila melanogaster
• Sequence 2: NP_525099.3
• Gene: Hrs / 33458
• FlyBaseID: FBgn0031450
• Length: 760
• Species: Drosophila melanogaster
• Alignment Length: 496
• Identity: 93/496 - (18%)
• Similarity: 183/496 - (36%)
• Gaps: 116/496 - (23%)

  Fly   154 NVLKHISNIVAT-----KNNNDLRNYKDT---------------ELQRFWMPD-----SKAKECY 193
            ||.:.:..:|.|     ::::..:..|||               |....:..|     :..:.|:
  Fly   101 NVRQKMLELVQTWAYAFRSSDKYQAIKDTMTILKAKGHTFPELREADAMFTADTAPNWADGRVCH 165

  Fly   194 DCSQKFSTFRRKHHCRLCGQIFCSKCCNQVVPGMIIRCDGDLKVCNYC----------------- 241
            .|..:|:...||||||.|||:||.:|..:..|......:.:::||:.|
  Fly   166 RCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSGGAKSG 230

  Fly   242 -----SKIVLTFLKSSSSEMGQ-DMQELQQHLSNKLEVQDSGSSLAKHPQMQRAPLPRKTSVGYQ 300
                 |::...:|.|:.::..| ..::.:|.|..:.|:|.:.:......:.|:..|.......|:
  Fly   231 PRPADSELPAEYLNSTLAQQVQTPARKTEQELKEEEELQLALALSQSEAEQQKPKLQSLPPAAYR 295

  Fly   301 EERFSSHPTYTTLSIDDRKNILQQSNSLITLHEEMQRDLPAQNCGQRLIEFLNSNNKSANEVQAV 365
            .::.|..|.    :..:.|...||               |.:.....|.::|   |:|..|.:.:
  Fly   296 MQQRSPSPE----APPEPKEYHQQ---------------PEEATNPELAKYL---NRSYWEQRKI 338

  Fly   366 AILNAMLAAGFLEPIVPDPEQMDFDSSLHYKFSKSSSSDTSRTMSPQFEANPHAEPQPPKSMDQS 430
            :..::|.:.....|:.|.|:.... ..|..|.:.....|       :|.||...:.:...:..:|
  Fly   339 SESSSMASPSAPSPMPPTPQPQQI-MPLQVKSADEVQID-------EFAANMRTQVEIFVNRMKS 395

  Fly   431 AEEKEKELENELENDRCYTTATSKLLASYCEHEEQLLAQMLRAHNLDQEW-----DKVLQMLCST 490
            ...:.:.:.|:......:.|.||.       |.:||  ..::..:..:.|     ||:.|:..|.
  Fly   396 NSSRGRSISNDSSVQTLFMTLTSL-------HSQQL--SYIKEMDDKRMWYEQLQDKLTQIKDSR 451

  Fly   491 AA-NHFKPEHCSNDLMDIRNYVNFKKVPGGRRKDSKIVHGVAFSKNVAHKDMATHVPFPRILLLQ 554
            || :..:.||..          ..:::...:.:..::  .:|...::..|....::.:.|.|.||
  Fly   452 AALDQLRQEHVE----------KLRRIAEEQERQRQM--QMAQKLDIMRKKKQEYLQYQRQLALQ 504

  Fly   555 CPIVYERIEGKFVTIETVLLQEK---EYLRNVCARIMSFKP 592
            .....||        |..|.||:   :||....|....:.|
  Fly   505 RIQEQER--------EMQLRQEQQKAQYLMGQSAPPFPYMP 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264	20/87 (23%)
		DEP	329..397	CDD:214489	11/67 (16%)
		Fab1_TCP	464..717	CDD:239450	27/138 (20%)
		PIPKc_PIKfyve	1479..1796	CDD:340437
Hrs	NP_525099.3	VHS_Hrs	4..141	CDD:340771	7/39 (18%)
		FYVE_Hrs	157..217	CDD:277260	19/59 (32%)
		GAT_Hrs	376..471	CDD:410592	21/120 (18%)
		PABP-1234	<501..641	CDD:130689	13/45 (29%)