DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fab1 and Pikfyve

DIOPT Version :9

Sequence 1:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	XP_006245133.1	Gene:	Pikfyve / 316457	RGDID:	1592067	Length:	2129	Species:	Rattus norvegicus

Alignment Length:	2210	Identity:	673/2210 - (30%)
Similarity:	990/2210 - (44%)	Gaps:	547/2210 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SPSKLTEFARNFEDKPESLFGRVVNKIQNV--YNQSYNTVNDISSGSSSSSSTQPVQVVGKSQFF 79
            |||.||.|.....|:.|..|....:...|:  :|:...........|.|||.:.| |:..::|
  Rat    43 SPSHLTHFKPLTPDQDEPPFKSAYSSFVNLFRFNKERGEGGQGEQQSPSSSWSSP-QIPSRTQ-- 104

  Fly    80 SDSQTSTAEIADVETSSQSSVRPQPPTTLSIRTNSETRGTSTSSNTAAEDSETSD-RVETLPL-- 141
                               |||...|....:......|.:..:.|......|::| |.:..|.
  Rat   105 -------------------SVRSPVPYKKQLNEELHRRSSVLAENILPNPQESTDSRRKAEPACG 150

  Fly   142 ---PTSEANQGRTVSNVLKHISNIVATKNNNDLRNYKDTELQRFWMPDSKAKECYDCSQKFSTFR 203
               |.: |.|.|::|.|||.:..|:..|:       :|::|:::|||||:.|||||||:||:|||
  Rat   151 GHDPRT-AVQLRSLSTVLKRLKEIMEGKS-------QDSDLKQYWMPDSQCKECYDCSEKFTTFR 207

  Fly   204 RKHHCRLCGQIFCSKCCNQVVPGMIIRCDGDLKVCNYCSKIVLTFLKSS-SSEMGQDMQELQQH- 266
            |:||||||||||||:||||.:||..:...|||:.|.||.||.|::..|: |:.:|:|:..|...
  Rat   208 RRHHCRLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSNSIGEDLNALSDST 272

  Fly   267 --------------------------------------------LSNKL-EVQ-DSGSSLAKHP- 284
                                                        ||.:| .|| |:|.|.|::.
  Rat   273 CSVSILDPSEPRTPVGSRKASRNIFLEDDLAWQSLIHPDSSSSALSTRLVSVQEDAGKSPARNRS 337

  Fly   285 ------QMQRAPLPR----KTSVGYQEERFSSHPTY-TTLSIDDRKNILQQSNSLITL------- 331
                  .:.|:..|.    :|||..|..|     .| .|.:.:|.:.||..|..|..|
  Rat   338 ASITNLSLDRSGSPMVPSYETSVSPQANR-----NYIRTETTEDERKILLDSAQLKDLWKKICHH 397

  Fly   332 --------HEEMQRDLPAQNC--GQRLIEFLNSNNKSANEVQAVAILNAMLAAGFLEPI------ 380
                    |....|..|  ||  |:.|:.:|..|...|...||:||..||:...:|:.:
  Rat   398 TSGMEFQDHRYWLRTHP--NCIVGKELVNWLIRNGHIATRAQAIAIGQAMVDGRWLDCVSHHDQL 460

  Fly   381 ------------------VPDPE-----------------QMDFDSSLHYKFSK-------SSSS 403
                              .|.|:                 .:.||.|...:.::       :|:|
  Rat   461 FRDEYALYRPLQSTEFSETPSPDSDSVNSVEGHSEPSWFKDIKFDDSDTEQIAEEGDDNLANSAS 525

  Fly   404 DTSRTMSPQFEAN----------------------------PHAEPQPPKS-------------- 426
            .:.||....|::.                            ||..|.|...
  Rat   526 PSKRTSVSSFQSTVDSDSAASISLNVELDNVNFHIKKPSKYPHVPPHPADQKEYLVSDTGGQQLS 590

  Fly   427 ----------MDQSAEEKEKEL--------ENEL-----ENDRCYTTATSKLLASYCEHEEQLLA 468
                      .::..|||.|||        .|.|     ||:.  ..|..:||::...|...||.
  Rat   591 ISDAFIKESLFNRRVEEKSKELPFTPLGWHHNNLELLREENEE--KQAMERLLSANHNHMMALLQ 653

  Fly   469 QMLRAHNLDQEWDKVLQMLCSTAANHFKPE--HCSNDLMDIRNYVNFKKVPGGRRKDSKIVHGVA 531
            |:|:..:|...|..::..|........:|:  |..:| ||||.:|:.||:|||::.||.:|:|..
  Rat   654 QLLQNESLSSSWRDIIVSLVCQVVQTVRPDVKHQDDD-MDIRQFVHIKKIPGGKKFDSVVVNGFV 717

  Fly   532 FSKNVAHKDMATHVPFPRILLLQCPIVY-ERIEGKFVTIETVLLQEKEYLRNVCARIMSFKPNVV 595
            .:||:|||.|.:.:..|:||||:|.|.| .|.|.||..|:.::|||:|:|:|...||:..:|.:|
  Rat   718 CTKNIAHKKMNSCIKNPKILLLKCSIEYLYREETKFTCIDPIVLQEREFLKNYVQRIVDVRPTLV 782

  Fly   596 LVHKNVAGIAQDLLRSYEVTLVLDVKLSVMERLSRTLQCDIVSSIESNITMPKLGYCNDFYIR-- 658
            ||.|.|:.||||:|..:.:|||::||..|:||:||..|.|:|.|::..:|.|.||.|:.||::
  Rat   783 LVEKTVSRIAQDMLLEHGITLVINVKSQVLERISRMTQGDLVVSMDQLLTKPHLGTCHKFYMQLF 847

  Fly   659 ---NYNGKTLMFFEKLTNPRGYTCLLRGGSNAELTRVKRVASALLFARYNWRLEMSFLLNEFAQP 720
               |...|||||||......|.|..|||||:.||.|||.:...::...|:.:||:|||::|||.|
  Rat   848 QLPNEQTKTLMFFEGCAQHLGCTIKLRGGSDYELARVKEILIFMICVAYHSQLEISFLMDEFAMP 912

  Fly   721 --LSPKPSI-----------------------------FDSKETSPKTETEA-------ELRSKR 747
              |:..||.                             ||:..:...|..|:       ||.:|.
  Rat   913 PTLTQSPSFHFLAEGRGEEGASQEQVSGSSLPQDPECPFDALSSDDSTLLESRTVPEKGELDNKS 977

  Fly   748 --PIILERKSEDKIT------------TIVSENVSDFTDPLRASQAEALSTSPCAPPVVEALAVE 798
              ..:...|.:|..|            .:|.|::.    ||...|.:|:...   .|......||
  Rat   978 VPQAVASLKHQDYTTPTCPAGIPCALFALVPESLL----PLHMDQQDAVGDE---QPETSQQTVE 1035

  Fly   799 PR----------------------------------YDNRFRTALSSTLLSVSPFLTFPLPYLET 829
            .:                                  |...|:..|...:|.:||.:||..|:|.|
  Rat  1036 QQDPKSQMRAFRDPLQDDTGMYVTEEVTSSEDKRKTYSLTFKQELKDVILCISPVITFREPFLLT 1100

  Fly   830 EQGRKCKLRKLFPAELYFSKQWSRTGLE-----RPDSMGDGEAGKSEPGNKENQ-MQLLPAHDFV 888
            |:|.:|..|..||.::|:|...::...|     :...:.|....:|..||.:.: :|:||:|:.|
  Rat  1101 EKGMRCSTRDYFPEQIYWSPLLNKEVKEMESRRKKQLLRDLSGLQSMNGNVQTKSIQVLPSHELV 1165

  Fly   889 LMKITAP-ASSRDIQSKLAEFRSFGGRL-PKGKAPMLRPK-------KKNAEVIQRPQK---VSE 941
            ..:|... ..|:.:...||::|:.|||: .|...|.:..|       .|:....:..::   :..
  Rat  1166 STRIAEHLGDSQSLGRMLADYRARGGRIQSKHLDPFVHSKDTSCTSGSKSGNKTESDEERGLIPS 1230

  Fly   942 EQLYK---DALDPQNHQRLPVLFCSFHYNPKGVSSFCKLPMLLDMKFYGQYDIMLEQFLQRYCCL 1003
            :.|:.   |.|:|.|||||.|||.|.........|.|..|.::.|:|||:.|:.|..||:|||..
  Rat  1231 DVLWPTKVDCLNPANHQRLCVLFSSSSAQSSNAPSACVSPWIVTMEFYGKNDLTLGIFLERYCFR 1295

  Fly  1004 FNSMCPS--CNLPMLGHVRRYVHSLGCVHVYLTEDLTRSDP---TRIYFTSWCSICNATTPTIPL 1063
            .:..|||  |:.||:.|:||:||..|||.:.|.| |....|   ..|...|||.||...||.:.|
  Rat  1296 SSYQCPSMFCDTPMVHHIRRFVHGQGCVQIILKE-LDSPVPGYQHTILTYSWCRICKQVTPVVAL 1359

  Fly  1064 SDAAKCLSLAKYLEMRFHGHAYKRRPPSTDAEQGGTVCEHSLHRDYVHHFSFRGVGAKFQYTPVE 1128
            |:.:..:|.|||||:||:||.|.||   .:||.    |.||:|.||..:||:..:.|.|.|:|:.
  Rat  1360 SNESWSMSFAKYLELRFYGHQYTRR---ANAEP----CGHSIHHDYHQYFSYNQMVASFSYSPIR 1417

  Fly  1129 VWETDLPSLTVQLDLPQPFQSAQVQEEIKNFSIKGHEVYNRIHERIADLATE------EENSPLV 1187
            :.|..:|...:.:....|.:.:.:| ::|:|..|..:||..:.||:|.|.|:      ||....:
  Rat  1418 LLEVCVPLPKIFIKRQAPLKVSLLQ-DLKDFFQKVSQVYLAVDERLASLKTDTFSKTREEKMEDI 1481

  Fly  1188 QHLKTMLTHDQFIFKQKIEIVHTLL----TDNRATAYDTSDALAMARRALAESIELWGPRLQEI- 1247
            ...|.|   ::..||...|.:...|    .|.........::|...:::|.|:::.|..|||::
  Rat  1482 FAQKEM---EEGEFKSWTEKMQARLMSSCVDTPQQLQSVLESLIAKKQSLCEALQAWNSRLQDLF 1543

  Fly  1248 -----------------------EKLTAKQA--HHIDSGTICTEELRPEQVQTADSSKVTTSS-- 1285
                                   .|::|...  .:|..|....|  :.::..|..||:.:|||
  Rat  1544 QQEKGRKRPSVPPSPGRLRQGEESKISAMDTSPRNISPGLHNGE--KEDRFLTTLSSQSSTSSTH 1606

  Fly  1286 --LPKENDPLECPSE-------DTETGASNSQTVLDKNFSIDQMLASTVNVYSDKKSIRKILTQL 1341
              ||   .|.|..:|       |.:| ||.|:.|.|     ..:|.||.:...:|.:::.|...|
  Rat  1607 LQLP---TPPEALAEQLVGGPSDLDT-ASGSEDVFD-----GHLLGSTDSQVKEKSTMKAIFANL 1662

  Fly  1342 LPSGNQVNPLQSPF-PAQDHLTLPLGSIPIHVRETDLSSVIAYSLTSMDYQKAIDE--------- 1396
            || ||..||:..|| |.:.:|......:||.|.|.:.||:||::|:..:|:.|::|
  Rat  1663 LP-GNSYNPIPFPFDPDKHYLMYEHERVPIAVCEKEPSSIIAFALSCKEYRNALEELSKATLWNN 1726

  Fly  1397 AE---ANSNAAHSSPQLKRKIPLAESVS---------------------------DAEDSPSLSR 1431
            ||   ..::|..:.|:....|.|.| ||                           .|..||.||.
  Rat  1727 AEEGLPTNSALDNRPKSSSPIRLPE-VSGGQTNRTVEGEPQPTKKASGMLSFFRGTAGKSPDLSS 1790

  Fly  1432 TSSNT-SAAPNASVPSPATAASESEEKSKE----------RIKQPPSPHITLAFQDHSCQFQCKI 1485
            ....| ..|.:|......|.....|.:..|          :.||..:||:.|.|.|.:.:|.|::
  Rat  1791 QKRETLRGADSAYYQVGQTGKEGMESQGLEPQDEVDGGDTQKKQLTNPHVELQFSDANAKFYCRL 1855

  Fly  1486 YFAREFDAMRSKSLKPPKLDKSLYRRLEKSKMREELRISQSRTGSEMELVRKPSDVGAPRTTEDD 1550
            |:|.||..||...|
  Rat  1856 YYAGEFHKMREVIL--------------------------------------------------- 1869

  Fly  1551 SNQEEDARIALARSLCKSVQWEARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYID 1615
            .:.|||    ..|||..|..|:|||||||:.|..|.||||:||:|...::..|..|||.||.||.
  Rat  1870 GSSEED----FIRSLSHSSPWQARGGKSGAAFYATEDDRFILKQMPRLEVQSFLDFAPHYFNYIT 1930

  Fly  1616 RCQQQQQPTLLAKIFGVFRVSVKKKDSFVER--SVMVMENLFYGCNIENKFDLKGSERNRLV--D 1676
            ...||::||.||||.||:|:..|...:..|:  .::||||||||..:...||||||.|||.|  |
  Rat  1931 NAVQQKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVMENLFYGRKMAQVFDLKGSLRNRNVKTD 1995

  Fly  1677 PSNQQGEIVLLDENLVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGLDKKNGV 1741
            ...:..::|||||||::|....|||:.||||:|||.:|..|:.||..:|::|||||||.|..:..
  Rat  1996 TGKESCDVVLLDENLLKMVRDNPLYIRSHSKSVLRTSIHSDAHFLSSHLIIDYSLLVGRDDTSNE 2060

  Fly  1742 LVLGIIDYIRTFTLDKRVESIIKGSGILGGKGKDPTVVNPERYKQRFIDAMDRYFLTVPDRWEGL 1806
            ||:||||||||||.||::|.::|.:|||||:||.||||:||.|:.||.:|||:|||.|||.|.||
  Rat  2061 LVVGIIDYIRTFTWDKKLEMVVKSTGILGGQGKMPTVVSPELYRTRFCEAMDKYFLMVPDHWTGL 2125

Fly 1807 1806
Rat 2126 2125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264	42/60 (70%)
		DEP	329..397	CDD:214489	23/125 (18%)
		Fab1_TCP	464..717	CDD:239450	109/260 (42%)
		PIPKc	1413..1797	CDD:295374	163/425 (38%)
Pikfyve	XP_006245133.1	FYVE_PIKfyve_Fab1	186..247	CDD:277264	42/60 (70%)
		DEP_PIKfyve	389..470	CDD:239895	18/82 (22%)
		Fab1_TCP	649..909	CDD:239450	109/260 (42%)
		BAR	1430..>1477	CDD:299863	13/47 (28%)
		PIPKc	1803..2116	CDD:238081	150/367 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338759
Domainoid	1	1.000	267	1.000	Domainoid score	I1810
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32115
Inparanoid	1	1.050	717	1.000	Inparanoid score	I609
OMA	1	1.010	-	-		QHG58433
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003143
OrthoInspector	1	1.000	-	-		oto98804
orthoMCL	1	0.900	-	-		OOG6_101979
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2110
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.660