DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fab1 and Pip5k1c

DIOPT Version :9

Sequence 1:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	XP_008763323.1	Gene:	Pip5k1c / 314641	RGDID:	1309938	Length:	692	Species:	Rattus norvegicus

Alignment Length:	591	Identity:	125/591 - (21%)
Similarity:	183/591 - (30%)	Gaps:	225/591 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1270 PEQVQTADSSKVTTSSLPKENDPLECPSEDTETGASNSQTVLDKNFSIDQMLASTVNVYSDKKSI 1334
            |::.::|::..||..:           :...|:||:...|                    .||:
  Rat     6 PDEAESAEAGAVTAEA-----------AWSAESGAAAGMT--------------------QKKA- 38

  Fly  1335 RKILTQLLPSGNQVNPLQSPFPAQDHLTLPLGSIPIHVRETDLSSVIAYSLTSMDYQKAIDEAEA 1399
              ||.:.        ||.:..|...|     |....| |..|.|....|..|
  Rat    39 --ILAEA--------PLVTGQPGPGH-----GKKLGH-RGVDASGETTYKKT------------- 74

  Fly  1400 NSNAAHSSPQLKRKIPLAESVSDAEDSPSLSRTSSNTSAAPNASVPSPATAASESEEKSKERIKQ 1464
                  :|..||..|.|           .:..|..|.|:.|...|........||.....|....
  Rat    75 ------TSSTLKGAIQL-----------GIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGSNL 122

  Fly  1465 PPSPHITLAFQDHSCQFQCKIYFAREFDAMRSK-SLKPPKLDKSLYRRLEKSKMREELRISQSRT 1528
            .|:.|    |||    |:.|.|....|...|.. .::|   |..||
  Rat   123 TPAHH----FQD----FRFKTYAPVAFRYFRELFGIRP---DDYLY------------------- 157

  Fly  1529 GSEMELVRKPSDVGAPRTTEDDSNQEEDARIALARSLCKSVQWE-ARGGKSGSRFCKTLDDRFVL 1592
                                               |||.....| :..|.|||.|..|.||.|::
  Rat   158 -----------------------------------SLCNEPLIELSNPGASGSVFYVTSDDEFII 187

  Fly  1593 KEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLLAKIFGVFRVSVKKKDSFVERSVMVMENLF-Y 1656
            |.:..::....:...|.|:..::    |...|||.|.:|::.|....|:.    .|:||.|:. .
  Rat   188 KTVMHKEAEFLQKLLPGYYMNLN----QNPRTLLPKFYGLYCVQSGGKNI----RVVVMNNVLPR 244

  Fly  1657 GCNIENKFDLKGSERNRLVDPSNQQGEI-VLLDENLVQMSWSKPLYVLSHSKT--VLRDAIQRDS 1718
            ...:..|||||||...|......::..: ...|.:.:|   ..|..:|..|.|  .|...:|||.
  Rat   245 VVKMHLKFDLKGSTYKRRASKKEKEKSLPTYKDLDFMQ---DMPEGLLLDSDTFGALVKTLQRDC 306

  Fly  1719 SFLEKNLVMDYSLLVGL-------------------DKK-------------------------- 1738
            ..||...:||||||:|:                   |:|
  Rat   307 LVLESFKIMDYSLLLGVHNIDQQERERQAEGAQSKADEKRPVAQKALYSTAMESIQGGAARGEAI 371

  Fly  1739 ------------NG-----VLVLGIIDYIRTFTLDKRVESIIKGSGILGGKGKDPTVVNPERYKQ 1786
                        ||     :|.:||||.::::...|::|...|.   |...|...:|..|..|.:
  Rat   372 ETDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKA---LVHDGDTVSVHRPSFYAE 433

  Fly  1787 RFIDAM 1792
            ||...|
  Rat   434 RFFKFM 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264
		DEP	329..397	CDD:214489
		Fab1_TCP	464..717	CDD:239450
		PIPKc	1413..1797	CDD:295374	99/448 (22%)
Pip5k1c	XP_008763323.1	PIPKc	103..443	CDD:214623	92/416 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810