Protein Alignment fab1 and fab1

DIOPT Version :10

• Sequence 1: NP_611269.1
• Gene: fab1 / 37033
• FlyBaseID: FBgn0028741
• Length: 1809
• Species: Drosophila melanogaster
• Sequence 2: NP_596090.2
• Gene: fab1 / 2541154
• PomBaseID: SPBC3E7.01
• Length: 1932
• Species: Schizosaccharomyces pombe
• Alignment Length: 2089
• Identity: 514/2089 - (24%)
• Similarity: 799/2089 - (38%)
• Gaps: 587/2089 - (28%)

  Fly   125 TAAEDS---ETSDRVETLPLPTSEANQGRTVSNVLKHISNIVATKNNNDLRNYKDTELQRFWMPD 186
            |||..:   |||.|::||...::|        .::|...|:|.|    .|:....|..:.|||.|
pombe     8 TAASPTFPVETSHRLDTLHTSSTE--------QIIKDSENVVHT----TLKLPTSTLSREFWMKD 60

  Fly   187 SKAKECYDCSQKFSTFRRKHHCRLCGQIFCSKCCNQVVPGMIIRCDGDLKVCNYCSKIVLT---- 247
            .:...|..|..:|:.||||||||:||:|.| |.|.:..||.|.|..|.:|||..|:.|::.
pombe    61 ERTNNCSLCETEFTLFRRKHHCRICGKIIC-KYCLKEAPGFIFRLQGSIKVCRPCASILVNNYSR 124

  Fly   248 ---FLKSSSSEMGQDMQELQQH-------LSNKLEVQDSGSSLAK--------HPQMQRAPL--- 291
               |..|.:....:|:.|  ||       |::..:|..|...|:.        ||. :.||:
pombe   125 SQLFNHSLNESKNRDLTE--QHPFVTLDELNSNDQVLSSFGDLSSTFEMPNNIHPP-EVAPMIAI 186

  Fly   292 -----------------------------------------------------PRKTSVGYQEER 303
                                                                 |...|..|:...
pombe   187 PSSRSNYDSPGWAHHSIFLDWSKRNLDSNVINVEDSESGKYNALTITNSYDAGPSSVSTDYRPVN 251

  Fly   304 FSSHPTYTTLSIDDRKNILQQSNSLITLH---EEMQRDLPAQNCGQRLIEFLN--SNNKSANEVQ 363
            |...|:|:.|    |||....|..:..::   :|..| |...:.|.|.:.|:|  .|.|:.:..:
pombe   252 FGKVPSYSKL----RKNKAFSSAKVSDMYLSADERNR-LEDFSKGDRGLSFVNLSPNIKATSYDR 311

  Fly   364 AVAILNAMLAAGFLEPIVPDPEQM-------DFDSSLHYKFSKSSSSDTSRTMSPQFEANPHAEP 421
            ...::|        ||.:.....:       |..:|.|:    .|.||.....:.....:.||..
pombe   312 LSTVIN--------EPFISRSSSLTDERGLADSGNSYHH----FSDSDDESLFNDGLGLSFHANS 364

  Fly   422 QPPKSMDQSAEE-----KEKELENEL--------------------------EN----------- 444
            ...|...|:...     .|..|.|.|                          ||
pombe   365 AIIKQRQQNVASIQRYGNESYLSNFLKAFLPKTVCDYLFPSSTIPDGLPALIENFNARVDKVNHP 429

  Fly   445 ------------DRCYTTATSK---------LLAS------YCEHEEQLLAQMLRAHNLD--QEW 480
                        .|..:..||.         :|.|      .|....:||.|||....:|  .:|
pombe   430 GGTEEPLPYQGKSRASSVVTSSKSTCILPPWILFSDSFNQLVCTFLGKLLFQMLNDEGVDSPMQW 494

  Fly   481 DKVLQMLCSTAANHFKPEHCSNDLMDIRNYVNFKKVPGGRRKDSKIVHGVAFSKNVAHKDMATHV 545
            ...|..:....|....|:..|.|.:|:|:||..||:|||..:|..:|:||.|||..:.|.|...:
pombe   495 VLCLPKILLKMALDLGPDIRSGDDIDVRSYVKIKKIPGGSIQDCFLVNGVLFSKKASSKSMDRSL 559

  Fly   546 PFPRILLLQCPIVYERIEGKFVTIETVLLQEKEYLRNVCARIMSFKPNVVLVHKNVAGIAQDLLR 610
            ..|||.||...:.|...|.:.::::.::.|::||:.|:..||...|||:|.....:..||.....
pombe   560 RRPRIALLTFSLDYACDEQRILSLDLIISQQEEYIINLVNRICMLKPNLVFAQGQIPSIALKYFE 624

  Fly   611 SYEVTLVLDVKLSVMERLSRTLQCDIVSSIESNITMPKLGYCNDFYIRNY-----NG--KTLMFF 668
            .:.|.....:|.||:..::|..:.||:|||:.....|:||.|..|.:|.|     .|  ||....
pombe   625 EHGVIAFHGLKESVLYDIARCCRADIISSIDKLSLCPRLGTCGRFQLRTYVVDENKGLRKTFAIL 689

  Fly   669 EKLTNPRGYTCLLRGGSNAELTRVKRVASALLFARYNWRLEMSFLLNEFAQPLSPKPSIFD---- 729
            ::.:...|.|.:|||....:|::||::...::...|:.:||.:.|.::|..    .|.:|:
pombe   690 DRCSERLGCTIVLRGADYNQLSKVKKIVELVVLIAYHIKLECALLRDKFVN----MPELFETTYQ 750

  Fly   730 --SKETSPKTETEAELRSKRPIILERKSEDKITTIVSENVSDFTDPLRASQAEALSTSPCAPP-- 790
              |:::.|...:.|..:.|     .:..|.|  ::.|:|.|  ..||........||.....|
pombe   751 SLSRKSLPSFASTAADKEK-----SQNHEKK--SLNSDNQS--LRPLENENQSVSSTQGSNSPLE 806

  Fly   791 VVEALAVEPRYDNRFRTALSSTLLSVSPFLTFPLPYLETEQGRKCKLRKLFPAELYFSKQWSRTG 855
            ::..|.....|.: ...||.:..|:.||||:.|||.|.
pombe   807 LINNLPASDDYSS-ITKALKTRFLTFSPFLSKPLPRLL--------------------------- 843

  Fly   856 LERPDSMGDGEAGKSEPGNKENQMQLLPAHDFVLMKITAPASSRDIQSKLAEFRSFGGRLPKGKA 920
                              |:.|..|      |:..|:.     :|:  ||..:.      |.|..
pombe   844 ------------------NQVNYYQ------FIRNKLL-----KDV--KLHPYS------PTGSF 871

  Fly   921 PMLRPKKKNAE----------VIQRPQKVSEEQ--LY----KDALDPQNHQRLPVLFCSFHYNPK 969
            .|.:.:..|.|          .|.......|:|  ||    |....|.:.||:.:|:...:   |
pombe   872 VMKQSENDNVEESYEESYKFFCIDERYHFLEKQWTLYYSHSKLMFSPFSSQRIILLYSIIN---K 933

  Fly   970 GVSSFCKLPMLLDMKFYGQYDIMLEQFLQRYCCLFNSMCPS--CNL-PMLGHVRRYVHSLGCVHV 1031
            ..|..|..|....::||.:.|..|.|:::..|...|..|..  |.. .||.|.|.|||....:.|
pombe   934 ETSVPCIGPERCLLEFYRETDCTLGQYIEDSCLNTNVSCGGEYCKTNDMLWHYRSYVHGNSRISV 998

  Fly  1032 YLTEDLTRSDP---TRIYFTSWCSICNATTPTIPLSDAAKCLSLAKYLEMRFHGHAYKRRPPSTD 1093
            :| |..:...|   .:|...|:|..|...|....:|:.....|..||||..|:....:.|
pombe   999 FL-ESFSCPVPGLEEKIIMWSYCKFCKKNTHITVMSEETWKYSFGKYLEFMFYNSQIRDR----- 1057

  Fly  1094 AEQGGTVCEHSLHRDYVHHFSFRGVGAKFQYTPVEVWETDLPSLTVQLDLPQPFQSAQVQE-EIK 1157
                ...|:||:...:||:|.:..:..:||...:|::|..:||:|::   ..|....:::| |.|
pombe  1058 ----FEFCDHSVMAQHVHYFGYCNMALRFQRDLIEIFELFVPSVTLR---NNPSYIKELKEKEYK 1115

  Fly  1158 NFSIKG------HEVYNRIHERIADLATEEEN----SPLVQHLKTMLTHDQFIFKQKIEIVHTLL 1212
            .  :||      ..|.:||::...|..|:.|.    :..:...:|:|:.|           :|.|
pombe  1116 R--LKGVIEKCLSSVASRINQIKCDWVTDPEKFESCTSEISKFRTLLSSD-----------YTEL 1167

  Fly  1213 TDNRATAY---DTSDALAM--ARRALAESIELWG-----------PRLQEIEKLTAKQAHHI--- 1258
            .....:.|   .|||.|::  ..|.|...:..|.           |..:|:.|:.|.|...:
pombe  1168 YSEFDSIYLNSSTSDYLSLNSILRVLQGKMVKWEQRFLDYQRLYLPSYKELSKIAAAQIKKVFLE 1232

  Fly  1259 -----------------------DSGTICTEELRPEQVQT-----------ADS----------- 1278
                                   ...|..|::...:..||           |||
pombe  1233 RPLSQTPLDLPETLENTQIDIYPSFKTESTDDQLEKVTQTNVASNKRVAPYADSMANVGSPESDC 1297

  Fly  1279 -SKVTTSSLPKENDPLECPSEDTETGASNSQTVLDKNFS------IDQMLASTVNVYSDKK---- 1332
             |..|:|.:||.|  ::..::.:......:..|.:..||      |.|  ...||:.|.|:
pombe  1298 FSVATSSDIPKAN--IDFTNDISTQNTFPASPVSNSGFSRQTYPNISQ--RQGVNMLSHKRKSAS 1358

  Fly  1333 -SIRKILTQLLPSGNQVNPLQSPFPAQDHLTLPLGSI----------PIHVRETDLSSVI----A 1382
             |.|:.:.....||..: |:.|...|:      :.||          ||..::..:||::    .
pombe  1359 TSDRRFVNASSTSGMNM-PISSSISAK------ISSIQNSTKYSPRKPIPAKDVRVSSLVRRFEE 1416

  Fly  1383 YSLTSMDYQKAIDEAEANSNAAHSSPQLKRKIPLAESVSD---------AEDSPSLSRTSSNTSA 1438
            .||...:.||. ||....:....:.|.:..| |:.|..:|         :||...::.|..|.:.
pombe  1417 LSLQLQEKQKR-DEELIKARRKRALPVVPSK-PVVEVFNDLNEAFDDENSEDENGINDTKENRAT 1479

  Fly  1439 APNASVPSPATAASESEEKSKERI--KQPPSPHITLAFQDHSCQFQCKIYFAREFDAMRSKSLKP 1501
            ..|.|       ..:|..|.:|.:  .:..||.   ||:|     ...|.|..|......::|:|
pombe  1480 ESNFS-------GVDSMSKERENVSSNEDNSPE---AFED-----IFGILFKNESGLEEQQNLEP 1529

  Fly  1502 ---------------PKLDK-SLYRRLEK------------------------------------ 1514
                           |..|| |:||.|..
pombe  1530 SSQMDKEGSKLPTSGPLADKTSVYRILSAFWNEWNSLNPPPFEFPLQPTEHMFSDSNVIIREDEP 1594

  Fly  1515 --------------SKMRE------ELRISQSRTGSEM----ELVRKPSDVGAPRTTEDDSNQEE 1555
                          |||.|      |...:|...||..    .|:.||:........|:.|
pombe  1595 SSLISFTLSSPDYLSKMVEIEDSMDEALTNQGLQGSTQFKIENLMLKPTGTHLKYQFEEGS---- 1655

  Fly  1556 DARI-----------ALAR----------SLCKSVQWEARGGKSGSRFCKTLDDRFVLKEMNSRD 1599
             ||:           ||.|          ||.:...||:.||||||.|.||.|.:::||.::..:
pombe  1656 -ARLSCKVFFAEQFSALRRACGCEETFVTSLARCSLWESSGGKSGSAFLKTFDKKYILKVLSRLE 1719

  Fly  1600 MTIFEPFAPKYFEYIDRCQQQQQPTLLAKIFGVFRVSVKK--KDSFVERSVMVMENLFYGCNIEN 1662
            ......|||.||:||.:....:.||.|.||||.:||.::.  ..:..:..:|:|||:||......
pombe  1720 SDSLLNFAPAYFDYISKVFFHELPTALTKIFGFYRVDIRNPTTGTICKTDIMIMENVFYDECPSR 1784

  Fly  1663 KFDLKGSERNRLVDPSNQQGEIVLLDENLVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVM 1727
            .||||||.|||.|:.:.:..| ||||||||::.:..|::|....|::|...:..|:.||.|..:|
pombe  1785 IFDLKGSMRNRHVESTGKVDE-VLLDENLVELIYESPIFVSEQLKSLLHSCLWNDTLFLSKLNIM 1848

  Fly  1728 DYSLLVGLDKKNGVLVLGIIDYIRTFTLDKRVESIIKGSGILGGKGKDPTVVNPERYKQRFIDAM 1792
            ||||:||:|.....|.:||||:|||:|.||::||.:|..|:: |:|.:||:|.|::||.||..||
pombe  1849 DYSLIVGIDYTKKELYVGIIDFIRTYTWDKKLESWVKEKGLV-GRGPEPTIVTPKQYKNRFRKAM 1912

  Fly  1793 DRYFLTVPD 1801
            |.|.|...|
pombe  1913 DCYILASQD 1921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264	30/60 (50%)
		DEP	329..397	CDD:214489	15/79 (19%)
		Fab1_TCP	464..717	CDD:239450	81/261 (31%)
		PIPKc_PIKfyve	1479..1796	CDD:340437	131/415 (32%)
fab1	NP_596090.2	FYVE	54..120	CDD:214499	28/65 (43%)
		Fab1_TCP	477..738	CDD:239450	65/275 (24%)
		MSS4	1322..1932	CDD:227578	144/464 (31%)