DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fab1 and PIP5K1C

DIOPT Version :9

Sequence 1:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	XP_011526147.1	Gene:	PIP5K1C / 23396	HGNCID:	8996	Length:	731	Species:	Homo sapiens

Alignment Length:	483	Identity:	103/483 - (21%)
Similarity:	153/483 - (31%)	Gaps:	159/483 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1391 QKAIDEAEANSNAAHSSPQLKRKIPLAESVSDAEDSPSLSRTSSNT----------------SAA 1439
            ||.....|..|..|...|...:|  |.....||....:..:|:|:|                |:.
Human    35 QKKAAPTEVLSMTAQPGPGHGKK--LGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGHLSSK 97

  Fly  1440 PNASVPSPATAASESEEKSKERIKQPPSPHITLAFQDHSCQFQCKIYFAREFDAMRSK-SLKPPK 1503
            |...|........||.....|.....|:.|    |||    |:.|.|....|...|.. .::|
Human    98 PERDVLMQDFYVVESIFFPSEGSNLTPAHH----FQD----FRFKTYAPVAFRYFRELFGIRP-- 152

  Fly  1504 LDKSLYRRLEKSKMREELRISQSRTGSEMELVRKPSDVGAPRTTEDDSNQEEDARIALARSLCKS 1568
             |..||                                                      |||..
Human   153 -DDYLY------------------------------------------------------SLCNE 162

  Fly  1569 VQWE-ARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLLAKIFGV 1632
            ...| :..|.|||.|..|.||.|::|.:..::....:...|.|:..::    |...|||.|.:|:
Human   163 PLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLN----QNPRTLLPKFYGL 223

  Fly  1633 FRVSVKKKDSFVERSVMVMENLF-YGCNIENKFDLKGSERNRLVDPSNQQGEIVLLDENLVQMSW 1696
            :.|....|:.    .|:||.|:. ....:..|||||||...|......::.......:.......
Human   224 YCVQSGGKNI----RVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDM 284

  Fly  1697 SKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGL-------------------DKK---- 1738
            .:.|.:.:.:.:.|...:|||...||...:||||||:|:                   |:|
Human   285 PEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQHERERQAQGAQSTSDEKRPVG 349

  Fly  1739 ----------------------------------NG-----VLVLGIIDYIRTFTLDKRVESIIK 1764
                                              ||     :|.:||||.::::...|::|...|
Human   350 QKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWK 414

  Fly  1765 GSGILGGKGKDPTVVNPERYKQRFIDAM 1792
            .   |...|...:|..|..|.:||...|
Human   415 A---LVHDGDTVSVHRPSFYAERFFKFM 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264
		DEP	329..397	CDD:214489
		Fab1_TCP	464..717	CDD:239450
		PIPKc	1413..1797	CDD:295374	97/461 (21%)
PIP5K1C	XP_011526147.1	PIPKc	103..443	CDD:214623	87/413 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810