DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fab1 and Pip5kl1

DIOPT Version :9

Sequence 1:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	XP_017172887.1	Gene:	Pip5kl1 / 227733	MGIID:	2448520	Length:	568	Species:	Mus musculus

Alignment Length:	492	Identity:	109/492 - (22%)
Similarity:	178/492 - (36%)	Gaps:	161/492 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1343 PSGNQVNPL-QSPFPAQDHLTLPLGSIPIHVRETDLSSVIAYSLTSMDYQKAIDEAEANSNAAHS 1406
            |:.::..|. |...|.:..:|.|...   |:.:..|              |..|::...:.:...
Mouse   107 PTSSEGGPAGQGHRPPRATVTRPFHQ---HLSQAAL--------------KGQDQSSEYAASVEV 154

  Fly  1407 SPQLKRKIPLAE-----------SVSDAEDSPSLSRTSSNTSAAPN----ASVPSPATAASE--S 1454
            .|..|.|.|...           .|..||..|.....:|.|...|.    .::.:|:..:.|  :
Mouse   155 EPAGKGKRPFRRLGTVVTRASRLVVRHAEAGPDSCIWASETPPKPEKRHLGAMATPSLRSHEVGA 219

  Fly  1455 EEKSKERIKQPPSPHITLAFQDHSCQFQCKIYFAREFDAMRSKSLKPPKL--DKSLYRRLEKSKM 1517
            :::..::.| ..|..||||                     |..:..||:|  .|...|..|....
Mouse   220 DQRGDKKGK-GESLAITLA---------------------RGLNTPPPRLCSGKIKTRPTEIPAH 262

  Fly  1518 REE-----------------LRISQSRT-------GSEMELVRKPSDVGAPRTTEDDSN------ 1552
            .:|                 ||..|||.       |.|:..:.:....|....|:...|
Mouse   263 SQEAGNKSISSGSRRGLLWHLRARQSRVGLFEVGPGHELHRMTRMMQEGLWAATQVSKNNPPTGP 327

  Fly  1553 -------------QEEDARI------ALARSLCKSV-----QWEARGG------------KSGSR 1581
                         .||...:      |.|| |.||:     .::|..|            ||.:.
Mouse   328 TTQKDYLEVMTQVHEEGFELGTLAGPAFAR-LRKSIGLTEEDYQATLGPGDPYLQFFSTSKSKAS 391

  Fly  1582 FCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLLAKIFGVF--RVSVKKKDSFV 1644
            |..|.|.||.:|.....::.:.....|:|.|::    ||...:|||::.||:  ||:..||..|:
Mouse   392 FFLTHDQRFFVKTQRRHEVHVLLAHLPRYVEHL----QQYPHSLLARLLGVYSLRVAQGKKKYFI 452

  Fly  1645 ERSVMVMENLFYGCN-IENKFDLKGSERNRLVDPSNQQGEIVLLDENL----------VQMSWSK 1698
                 :|:.:||..: |..::|:||...:|.|||:.:...:||:.::|          .|.||
Mouse   453 -----IMQCIFYPTSRISERYDIKGCNISRWVDPAPEGSPLVLVLKDLNFQEKTMRLGAQRSW-- 510

  Fly  1699 PLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGL 1735
                      .||. ::.|::||.:..|:||||||.:
Mouse   511 ----------FLRQ-MELDTAFLREVNVLDYSLLVAI 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264
		DEP	329..397	CDD:214489
		Fab1_TCP	464..717	CDD:239450
		PIPKc	1413..1797	CDD:295374	97/421 (23%)
Pip5kl1	XP_017172887.1	PIPKc	299..>543	CDD:391950	66/261 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810