DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fab1 and PIKFYVE

DIOPT Version :9

Sequence 1:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	XP_011509080.1	Gene:	PIKFYVE / 200576	HGNCID:	23785	Length:	2110	Species:	Homo sapiens

Alignment Length:	2215	Identity:	684/2215 - (30%)
Similarity:	991/2215 - (44%)	Gaps:	556/2215 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SPSKLTEFARNFEDKPESLFGRVVNKIQNVYNQSYNTVNDISSGSSSSSSTQPVQVVGKSQFFSD 81
            |||.||.|.....|:.|..|....:...|::.  :|  .:.:.|..           |:.|..|.
Human    23 SPSHLTHFKPLTPDQDEPPFKSAYSSFVNLFR--FN--KERAEGGQ-----------GEQQPLSG 72

  Fly    82 SQTSTAEIADVETSSQSSVRPQPPTTLSIRTNSETRGTSTSSNT---AAEDSETSDRVETLPLPT 143
            |.||..     ..|...|||...|....:....:.|.::.:.|:   ..|:::|..:.|    ||
Human    73 SWTSPQ-----LPSRTQSVRSPTPYKKQLNEELQRRSSALADNSLQHPQENTDTRRKAE----PT 128

  Fly   144 ------SEANQGRTVSNVLKHISNIVATKNNNDLRNYKDTELQRFWMPDSKAKECYDCSQKFSTF 202
                  ..|.|.|::|.|||.:..|:..|:       :|::|:::|||||:.|||||||:||:||
Human   129 FGGHDPRTAVQLRSLSTVLKRLKEIMEGKS-------QDSDLKQYWMPDSQCKECYDCSEKFTTF 186

  Fly   203 RRKHHCRLCGQIFCSKCCNQVVPGMIIRCDGDLKVCNYCSKIVLTFLKSS-SSEMGQDMQELQQH 266
            ||:||||||||||||:||||.:||..:...|||:.|.||.||.|::..|: |:.:|:|:..|...
Human   187 RRRHHCRLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSNSIGEDLNALSDS 251

  Fly   267 LSNKLEVQDS------GSSLAK---------------HPQMQRAPLPRKTSVGYQEERFSS---- 306
            ..:...:..|      ||..|.               ||.....||..:. |..||:...|
Human   252 ACSVSVLDPSEPRTPVGSRKASRNIFLEDDLAWQSLIHPDSSNTPLSTRL-VSVQEDAGKSPARN 315

  Fly   307 -HPTYTTLSID-----------------------------DRKNILQQSNSLITL---------- 331
             ..:.|.||:|                             |.:.||..|..|..|
Human   316 RSASITNLSLDRSGSPMVPSYETSVSPQANRTYVRTETTEDERKILLDSVQLKDLWKKICHHSSG 380

  Fly   332 -----HEEMQRDLPAQNC--GQRLIEFLNSNNKSANEVQAVAILNAMLAAGFLEPI--------- 380
                 |....|..|  ||  |:.|:.:|..|...|...||:||..||:...:|:.:
Human   381 MEFQDHRYWLRTHP--NCIVGKELVNWLIRNGHIATRAQAIAIGQAMVDGRWLDCVSHHDQLFRD 443

  Fly   381 ---------------VPDPE-----------------QMDFDSSLHYKFSK-------SSSSDTS 406
                           .|.|:                 .:.||.|...:.::       :|:|.:.
Human   444 EYALYRPLQSTEFSETPSPDSDSVNSVEGHSEPSWFKDIKFDDSDTEQIAEEGDDNLANSASPSK 508

  Fly   407 RTMSPQFEAN----------------------------PHAEPQPPKS----------------- 426
            ||....|::.                            ||..|.|...
Human   509 RTSVSSFQSTVDSDSAASISLNVELDNVNFHIKKPSKYPHVPPHPADQKEYLISDTGGQQLSISD 573

  Fly   427 -------MDQSAEEKEKEL--------ENELE---NDRCYTTATSKLLASYCEHEEQLLAQMLRA 473
                   .::..|||.|||        .|.||   .:.....|..:||::...|...||.|:|.:
Human   574 AFIKESLFNRRVEEKSKELPFTPLGWHHNNLELLREENGEKQAMERLLSANHNHMMALLQQLLHS 638

  Fly   474 HNLDQEW-DKVLQMLCSTAANHFKPEHCSNDLMDIRNYVNFKKVPGGRRKDSKIVHGVAFSKNVA 537
            .:|...| |.::.::|.............:|.||||.:|:.||:|||::.||.:|:|...:||:|
Human   639 DSLSSSWRDIIVSLVCQVVQTVRPDVKNQDDDMDIRQFVHIKKIPGGKKFDSVVVNGFVCTKNIA 703

  Fly   538 HKDMATHVPFPRILLLQCPIVY-ERIEGKFVTIETVLLQEKEYLRNVCARIMSFKPNVVLVHKNV 601
            ||.|::.:..|:||||:|.|.| .|.|.||..|:.::|||:|:|:|...||:..:|.:|||.|.|
Human   704 HKKMSSCIKNPKILLLKCSIEYLYREETKFTCIDPIVLQEREFLKNYVQRIVDVRPTLVLVEKTV 768

  Fly   602 AGIAQDLLRSYEVTLVLDVKLSVMERLSRTLQCDIVSSIESNITMPKLGYCNDFYIR-----NYN 661
            :.||||:|..:.:|||::||..|:||:||..|.|:|.|::..:|.|.||.|:.||::     |..
Human   769 SRIAQDMLLEHGITLVINVKSQVLERISRMTQGDLVMSMDQLLTKPHLGTCHKFYMQIFQLPNEQ 833

  Fly   662 GKTLMFFEKLTNPRGYTCLLRGGSNAELTRVKRVASALLFARYNWRLEMSFLLNEFAQP--LSPK 724
            .|||||||......|.|..|||||:.||.|||.:...::...|:.:||:|||::|||.|  |...
Human   834 TKTLMFFEGCPQHLGCTIKLRGGSDYELARVKEILIFMICVAYHSQLEISFLMDEFAMPPTLMQN 898

  Fly   725 PSIFDS---------------------------KETSPKTETE-AELRSKRPIILER-------- 753
            || |.|                           .|:.|..::. .|||    |:.|:
Human   899 PS-FHSLIEGRGHEGAVQEQYGGGSIPWDPDIPPESLPCDDSSLLELR----IVFEKGEQENKNL 958

  Fly   754 -------KSEDKITTI------------VSEN-----VSDFTDPLRASQAEAL-STSPCAPP--- 790
                   |.::..||.            |.|:     |.|..|.|.:.|.|.| .|.....|
Human   959 PQAVASVKHQEHSTTACPAGLPCAFFAPVPESLLPLPVDDQQDALGSEQPETLQQTVVLQDPKSQ 1023

  Fly   791 ----------------VVEALAVEPR---YDNRFRTALSSTLLSVSPFLTFPLPYLETEQGRKCK 836
                            ..|..:.|.:   |...|:..|...:|.:||.:||..|:|.||:|.:|.
Human  1024 IRAFRDPLQDDTGLYVTEEVTSSEDKRKTYSLAFKQELKDVILCISPVITFREPFLLTEKGMRCS 1088

  Fly   837 LRKLFPAELYFS---------------KQWSR--TGLERPDSMGDGEAGKSEPGNKENQMQLLPA 884
            .|..|..::|:|               ||..|  :||:   .|......||        :|:||:
Human  1089 TRDYFAEQVYWSPLLNKEFKEMENRRKKQLLRDLSGLQ---GMNGSIQAKS--------IQVLPS 1142

  Fly   885 HDFVLMKITAP-ASSRDIQSKLAEFRSFGGRL-PKGKAPMLRPK-----------KKNAEVIQRP 936
            |:.|..:|... ..|:.:...||::|:.|||: ||...|....|           .||....:|.
Human  1143 HELVSTRIAEHLGDSQSLGRMLADYRARGGRIQPKNSDPFAHSKDASSTSSGQSGSKNEGDEERG 1207

  Fly   937 QKVSEE--QLYKDALDPQNHQRLPVLFCSFHYNPKGVSSFCKLPMLLDMKFYGQYDIMLEQFLQR 999
            ..:|:.  ....|.|:|.|||||.|||.|.........|.|..|.::.|:|||:.|:.|..||:|
Human  1208 LILSDAVWSTKVDCLNPINHQRLCVLFSSSSAQSSNAPSACVSPWIVTMEFYGKNDLTLGIFLER 1272

  Fly  1000 YCCLFNSMCPS--CNLPMLGHVRRYVHSLGCVHVYLTEDLTRSDP---TRIYFTSWCSICNATTP 1059
            ||...:..|||  |:.||:.|:||:||..|||.:.|.| |....|   ..|...|||.||...||
Human  1273 YCFRPSYQCPSMFCDTPMVHHIRRFVHGQGCVQIILKE-LDSPVPGYQHTILTYSWCRICKQVTP 1336

  Fly  1060 TIPLSDAAKCLSLAKYLEMRFHGHAYKRRPPSTDAEQGGTVCEHSLHRDYVHHFSFRGVGAKFQY 1124
            .:.||:.:..:|.|||||:||:||.|.||   .:||.    |.||:|.||..:||:..:.|.|.|
Human  1337 VVALSNESWSMSFAKYLELRFYGHQYTRR---ANAEP----CGHSIHHDYHQYFSYNQMVASFSY 1394

  Fly  1125 TPVEVWETDLPSLTVQLDLPQPFQSAQVQEEIKNFSIKGHEVYNRIHERIADLATE------EEN 1183
            :|:.:.|..:|...:.:....|.:.:.:| ::|:|..|..:||..|.||:|.|.|:      ||.
Human  1395 SPIRLLEVCVPLPKIFIKRQAPLKVSLLQ-DLKDFFQKVSQVYVAIDERLASLKTDTFSKTREEK 1458

  Fly  1184 SPLVQHLKTMLTHDQFIFKQKIEIVHTLLTDNRATAYDTS-------DALAMARRALAESIELWG 1241
            ...:...|.|   ::..||..||.:...|   .:::.||.       ::|...:::|.|.::.|.
Human  1459 MEDIFAQKEM---EEGEFKNWIEKMQARL---MSSSVDTPQQLQSVFESLIAKKQSLCEVLQAWN 1517

  Fly  1242 PRLQEI------------------------EKLTAKQA--HHIDSGTICTEELRPEQVQTADSSK 1280
            .|||::                        .|::|..|  .:|..|....|  :.::..|..||:
Human  1518 NRLQDLFQQEKGRKRPSVPPSPGRLRQGEESKISAMDASPRNISPGLQNGE--KEDRFLTTLSSQ 1580

  Fly  1281 VTTSS----LPKENDPLECPSEDTETG------ASNSQTVLDKNFSIDQMLASTVNVYSDKKSIR 1335
            .:|||    ||   .|.|..||.:..|      ||:|:.|.|     ..:|.||.:...:|.:::
Human  1581 SSTSSTHLQLP---TPPEVMSEQSVGGPPELDTASSSEDVFD-----GHLLGSTDSQVKEKSTMK 1637

  Fly  1336 KILTQLLPSGNQVNPLQSPF-PAQDHLTLPLGSIPIHVRETDLSSVIAYSLTSMDYQKAIDE--- 1396
            .|...||| ||..||:..|| |.:.:|......:||.|.|.:.||:||::|:..:|:.|::|
Human  1638 AIFANLLP-GNSYNPIPFPFDPDKHYLMYEHERVPIAVCEKEPSSIIAFALSCKEYRNALEELSK 1701

  Fly  1397 ------AE---ANSNAAHSSPQLKRKIPLAESV--------------------------SDAEDS 1426
                  ||   ..::.:.|.|:....|.|.|..                          ..|..|
Human  1702 ATQWNSAEEGLPTNSTSDSRPKSSSPIRLPEMSGGQTNRTTETEPQPTKKASGMLSFFRGTAGKS 1766

  Fly  1427 PSLSRTSSNT-SAAPNASVPSPATAASESEEKSKE----------RIKQPPSPHITLAFQDHSCQ 1480
            |.||.....| ..|.:|......|....:|.:..|          :.||..:||:.|.|.|.:.:
Human  1767 PDLSSQKRETLRGADSAYYQVGQTGKEGTENQGVEPQDEVDGGDTQKKQLINPHVELQFSDANAK 1831

  Fly  1481 FQCKIYFAREFDAMRSKSLKPPKLDKSLYRRLEKSKMREELRISQSRTGSEMELVRKPSDVGAPR 1545
            |.|::|:|.||..||...|
Human  1832 FYCRLYYAGEFHKMREVIL---------------------------------------------- 1850

  Fly  1546 TTEDDSNQEEDARIALARSLCKSVQWEARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKY 1610
                ||::|:     ..|||..|..|:|||||||:.|..|.||||:||:|...::..|..|||.|
Human  1851 ----DSSEED-----FIRSLSHSSPWQARGGKSGAAFYATEDDRFILKQMPRLEVQSFLDFAPHY 1906

  Fly  1611 FEYIDRCQQQQQPTLLAKIFGVFRVSVKKKDSFVER--SVMVMENLFYGCNIENKFDLKGSERNR 1673
            |.||....||::||.||||.||:|:..|...:..|:  .::||||||||..:...||||||.|||
Human  1907 FNYITNAVQQKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVMENLFYGRKMAQVFDLKGSLRNR 1971

  Fly  1674 LV--DPSNQQGEIVLLDENLVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGLD 1736
            .|  |...:..::|||||||::|....|||:.||||.|||.:|..||.||..:|::|||||||.|
Human  1972 NVKTDTGKESCDVVLLDENLLKMVRDNPLYIRSHSKAVLRTSIHSDSHFLSSHLIIDYSLLVGRD 2036

  Fly  1737 KKNGVLVLGIIDYIRTFTLDKRVESIIKGSGILGGKGKDPTVVNPERYKQRFIDAMDRYFLTVPD 1801
            ..:..||:||||||||||.||::|.::|.:|||||:||.||||:||.|:.||.:|||:|||.|||
Human  2037 DTSNELVVGIIDYIRTFTWDKKLEMVVKSTGILGGQGKMPTVVSPELYRTRFCEAMDKYFLMVPD 2101

  Fly  1802 RWEGL 1806
            .|.||
Human  2102 HWTGL 2106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264	42/60 (70%)
		DEP	329..397	CDD:214489	23/125 (18%)
		Fab1_TCP	464..717	CDD:239450	108/259 (42%)
		PIPKc	1413..1797	CDD:295374	162/424 (38%)
PIKFYVE	XP_011509080.1	FYVE_PIKfyve_Fab1	166..227	CDD:277264	42/60 (70%)
		DEP_PIKfyve	369..450	CDD:239895	18/82 (22%)
		Fab1_TCP	629..889	CDD:239450	108/259 (42%)
		PIPKc	1784..2097	CDD:238081	151/367 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145054
Domainoid	1	1.000	265	1.000	Domainoid score	I1903
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32115
Inparanoid	1	1.050	720	1.000	Inparanoid score	I637
Isobase	1	0.950	-	0	Normalized mean entropy	S5320
OMA	1	1.010	-	-		QHG58433
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003143
OrthoInspector	1	1.000	-	-		oto91739
orthoMCL	1	0.900	-	-		OOG6_101979
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2108
SonicParanoid	1	1.000	-	-		X2110
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.640