DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fab1 and Pikfyve

DIOPT Version :9

Sequence 1:NP_611269.1 Gene:fab1 / 37033 FlyBaseID:FBgn0028741 Length:1809 Species:Drosophila melanogaster
Sequence 2:XP_006495839.1 Gene:Pikfyve / 18711 MGIID:1335106 Length:2109 Species:Mus musculus


Alignment Length:2224 Identity:681/2224 - (30%)
Similarity:995/2224 - (44%) Gaps:575/2224 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SPSKLTEFARNFEDKPESLFGRVVNKIQNV--YNQSYNTVNDISSGSSSSSSTQPVQVVGKSQFF 79
            |||.||.|.....|:.|..|....:...|:  :|:...........|.|||...| |:..::|  
Mouse    23 SPSHLTHFKPLTPDQDEPPFKSAYSSFVNLFRFNKERGEGGQGEQQSPSSSWASP-QIPSRTQ-- 84

  Fly    80 SDSQTSTAEIADVETSSQSSVRPQPPTTLSIRTNSETRGTSTSSNTAAEDSETSD-RVETLPL-- 141
                               |||...|....:......|.:..:.||.....|::| |.:..|.  
Mouse    85 -------------------SVRSPVPYKKQLNEELHRRSSVLAENTLPHPQESTDSRRKAEPACG 130

  Fly   142 ---PTSEANQGRTVSNVLKHISNIVATKNNNDLRNYKDTELQRFWMPDSKAKECYDCSQKFSTFR 203
               |.: |.|.|::|.|||.:..|:..|:       :|::|:::|||||:.|||||||:||:|||
Mouse   131 GHDPRT-AVQLRSLSTVLKRLKEIMEGKS-------QDSDLKQYWMPDSQCKECYDCSEKFTTFR 187

  Fly   204 RKHHCRLCGQIFCSKCCNQVVPGMIIRCDGDLKVCNYCSKIVLTFLKSS-SSEMGQDMQELQQH- 266
            |:||||||||||||:||||.:||..:...|||:.|.||.||.|::..|: |:.:|:|:..|... 
Mouse   188 RRHHCRLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSNSIGEDLNALSDST 252

  Fly   267 --------------------------------------------LSNKL-EVQ-DSGSSLAKHP- 284
                                                        ||.:| .|| |:|.|.|::. 
Mouse   253 CSVSILDPSEPRTPVGSRKASRNIFLEDDLAWQSLIHPDSSNSALSTRLVSVQEDAGKSPARNRS 317

  Fly   285 ------QMQRAPLPR----KTSVGYQEERFSSHPTY-TTLSIDDRKNILQQSNSLITL------- 331
                  .:.|:..|.    :|||..|..|     .| .|.:.:|.:.||..|..|..|       
Mouse   318 ASITNLSLDRSGSPMVPSYETSVSPQANR-----NYIRTETTEDERKILLDSAQLKDLWKKICHH 377

  Fly   332 --------HEEMQRDLPAQNC--GQRLIEFLNSNNKSANEVQAVAILNAMLAAGFLEPI------ 380
                    |....|..|  ||  |:.|:.:|..|...|...||:||..||:...:|:.:      
Mouse   378 TSGMEFQDHRYWLRTHP--NCIVGKELVNWLIRNGHIATRAQAIAIGQAMVDGRWLDCVSHHDQL 440

  Fly   381 ------------------VPDPE-----------------QMDFDSSLHYKFSK-------SSSS 403
                              .|.|:                 .:.||.|...:.::       :|:|
Mouse   441 FRDEYALYRPLQSTEFSETPSPDSDSVNSVEGHSEPSWFKDIKFDDSDTEQIAEEGDDNLANSAS 505

  Fly   404 DTSRTMSPQFEAN----------------------------PHAEPQPPKS-------------- 426
            .:.||....|::.                            ||..|.|...              
Mouse   506 PSKRTSVSSFQSTVDSDSAASISLNVELDNVNFHIKKPSKYPHVPPHPADQKEYLVSDTGGQQLS 570

  Fly   427 ----------MDQSAEEKEKEL--------ENEL-----ENDRCYTTATSKLLASYCEHEEQLLA 468
                      .::..|||.|||        .|.|     ||:.  ..|..:||::...|...||.
Mouse   571 ISDAFIKESLFNRRVEEKSKELPFTPLGWHHNNLELLREENEE--KQAMERLLSANHNHMMALLQ 633

  Fly   469 QMLRAHNLDQEWDKVLQMLCSTAANHFKPE--HCSNDLMDIRNYVNFKKVPGGRRKDSKIVHGVA 531
            |:|:..:|...|..::..|........:|:  |..:| ||||.:|:.||:|||::.||.:|:|..
Mouse   634 QLLQNESLSSSWRDIIVSLVCQVVQTVRPDVKHQDDD-MDIRQFVHIKKIPGGKKFDSVVVNGFV 697

  Fly   532 FSKNVAHKDMATHVPFPRILLLQCPIVY-ERIEGKFVTIETVLLQEKEYLRNVCARIMSFKPNVV 595
            .:||:|||.|.:.:..|:||||:|.|.| .|.|.||..|:.::|||:|:|:|...||:..:|.:|
Mouse   698 CTKNIAHKKMNSCIKNPKILLLKCSIEYLYREETKFTCIDPIVLQEREFLKNYVQRIVDVRPTLV 762

  Fly   596 LVHKNVAGIAQDLLRSYEVTLVLDVKLSVMERLSRTLQCDIVSSIESNITMPKLGYCNDFYIR-- 658
            ||.|.|:.||||:|..:.:|||::||..|:||:||..|.|:|.|::..:|.|.||.|:.||::  
Mouse   763 LVEKTVSRIAQDMLLEHGITLVINVKSQVLERISRMTQGDLVVSMDQLLTKPHLGTCHKFYMQIF 827

  Fly   659 ---NYNGKTLMFFEKLTNPRGYTCLLRGGSNAELTRVKRVASALLFARYNWRLEMSFLLNEFAQP 720
               |...|||||||......|.|..|||||:.||.|||.:...::...|:.:||:|||::|||.|
Mouse   828 QLPNEQTKTLMFFEGCPQHLGCTIKLRGGSDYELARVKEILIFMICVAYHSQLEISFLMDEFAMP 892

  Fly   721 --LSPKPSIF------------------DSKETSPKTETEAELRSKRPIILERKS-------EDK 758
              |...||..                  .|....|:...|| |.|:...:||.::       ::|
Mouse   893 PTLMQSPSFHLLTEGRGEEGASQEQVSGSSLPQDPECPREA-LSSEDSTLLESRTVLEKGELDNK 956

  Fly   759 I--TTIVSENVSDFTD--------------------PLRASQAEAL---------STSPCAPPVV 792
            .  ..:.|....|:|.                    ||...|.:|:         .|.....|..
Mouse   957 SIPQAVASLKHQDYTTPTCPAGIPCALFALVPESLLPLHMDQQDAVGNEQPETSQQTDEQQDPKS 1021

  Fly   793 EALAV-EPRYDN---------------------RFRTALSSTLLSVSPFLTFPLPYLETEQGRKC 835
            :..|. :|..|:                     .|:..|...:|.:||.:||..|:|.||:|.:|
Mouse  1022 QMKAFRDPLQDDTGMYVTEEVTSSEDQRKTYALTFKQELKDVILCISPVITFREPFLLTEKGMRC 1086

  Fly   836 KLRKLFPAELYFS---------------KQWSR--TGLERPDSMGDGEAGKSEPGNKENQMQLLP 883
            ..|..||.::|:|               ||..|  :||:   .|......||        :|:||
Mouse  1087 STRDYFPEQIYWSPLLNKEVKEMESRRKKQLLRDLSGLQ---GMNGSVQAKS--------IQVLP 1140

  Fly   884 AHDFVLMKITAP-ASSRDIQSKLAEFRSFGGRL-PKGKAPMLRPKKKN----------------- 929
            :|:.|..:|... ..|:.:...||::|:.|||: .|...|.:..|..:                 
Mouse  1141 SHELVSTRIAEHLGDSQTLGRMLADYRARGGRIQSKHLDPFVHSKDASCTSGGKSGNKTESDEER 1205

  Fly   930 ----AEVIQRPQKVSEEQLYKDALDPQNHQRLPVLFCSFHYNPKGVSSFCKLPMLLDMKFYGQYD 990
                ::||. |.||       |.|:|.|||||.|||.|.........|.|..|.::.|:|||:.|
Mouse  1206 GLIPSDVIW-PTKV-------DCLNPANHQRLCVLFSSSSAQSSNAPSACVSPWIVTMEFYGKND 1262

  Fly   991 IMLEQFLQRYCCLFNSMCPS--CNLPMLGHVRRYVHSLGCVHVYLTEDLTRSDP---TRIYFTSW 1050
            :.|..||:|||...:..|||  |:.||:.|:||:||..|||.:.|.| |....|   ..|...||
Mouse  1263 LTLGIFLERYCFRSSYQCPSMFCDTPMVHHIRRFVHGQGCVQIILKE-LDSPVPGYQHTILTYSW 1326

  Fly  1051 CSICNATTPTIPLSDAAKCLSLAKYLEMRFHGHAYKRRPPSTDAEQGGTVCEHSLHRDYVHHFSF 1115
            |.||...||.:.||:.:..:|.|||||:||:||.|.||   .:||.    |.||:|.||..:||:
Mouse  1327 CRICKQVTPVVALSNESWSMSFAKYLELRFYGHQYTRR---ANAEP----CGHSIHHDYHQYFSY 1384

  Fly  1116 RGVGAKFQYTPVEVWETDLPSLTVQLDLPQPFQSAQVQEEIKNFSIKGHEVYNRIHERIADLATE 1180
            ..:.|.|.|:|:.:.|..:|...:.:....|.:.:.:| ::|:|..|..:||..:.||:|.|.|:
Mouse  1385 NQMVASFSYSPIRLLEVCVPLPKIFIKRQAPLKVSLLQ-DLKDFFQKVSQVYLAVDERLASLKTD 1448

  Fly  1181 ------EENSPLVQHLKTMLTHDQFIFKQKIEIVHTLLTDNRATAYDTS-------DALAMARRA 1232
                  ||....:...|.|   ::..||...|.:...|   .:::.||.       ::|...:::
Mouse  1449 TFSKTREEKMEDIFAQKEM---EEGEFKNWTEKMQARL---MSSSVDTPQQLQSIFESLIAKKQS 1507

  Fly  1233 LAESIELWGPRLQEI---EK-------------LTAKQAHHIDSGTICTEELRP--------EQV 1273
            |.|.::.|..|||::   ||             |...:...|::.......:.|        ::.
Mouse  1508 LCEVLQAWNSRLQDLFQQEKGRKRPSVPPSPGRLRQGEESKINAMDTSPRNISPGLHNGEKEDRF 1572

  Fly  1274 QTADSSKVTTSS----LPKENDPLECPSEDTETG------ASNSQTVLDKNFSIDQMLASTVNVY 1328
            .|..||:.:|||    ||   .|.|..:|....|      ||.|:.|.|     ..:|.||.:..
Mouse  1573 LTTLSSQSSTSSTHLQLP---TPPEALAEQVVGGPTDLDSASGSEDVFD-----GHLLGSTDSQV 1629

  Fly  1329 SDKKSIRKILTQLLPSGNQVNPLQSPF-PAQDHLTLPLGSIPIHVRETDLSSVIAYSLTSMDYQK 1392
            .:|.:::.|...||| ||..||:..|| |.:.:|......:||.|.|.:.||:||::|:..:|:.
Mouse  1630 KEKSTMKAIFANLLP-GNSYNPIPFPFDPDKHYLMYEHERVPIAVCEKEPSSIIAFALSCKEYRN 1693

  Fly  1393 AIDE---------AE----ANSNAAHSSPQLKRKIPLAE-------SVSDAEDSPSLSRTSSNTS 1437
            |::|         ||    ||| |..:.|:....|.|.|       ...:||..|: .:.|...|
Mouse  1694 ALEELSKATLRNSAEEGLPANS-ALDNRPKSSSPIRLPEISGGQTNRTVEAEPQPT-KKASGMLS 1756

  Fly  1438 AAPNASVPSPATAASESE-------------EKSKERI------------------KQPPSPHIT 1471
            .....:..||..::.:.|             :..||.:                  ||..:||:.
Mouse  1757 FFRGTAGKSPDLSSQKRETLRGADSAYYQVGQAGKEGLESQGLEPQDEVDGGDTQKKQLTNPHVE 1821

  Fly  1472 LAFQDHSCQFQCKIYFAREFDAMRSKSLKPPKLDKSLYRRLEKSKMREELRISQSRTGSEMELVR 1536
            |.|.|.:.:|.|::|:|.||..||...|                                     
Mouse  1822 LQFSDANAKFYCRLYYAGEFHKMREVIL------------------------------------- 1849

  Fly  1537 KPSDVGAPRTTEDDSNQEEDARIALARSLCKSVQWEARGGKSGSRFCKTLDDRFVLKEMNSRDMT 1601
                         .|::||     ..|||..|..|:|||||||:.|..|.||||:||:|...::.
Mouse  1850 -------------GSSEEE-----FIRSLSHSSPWQARGGKSGAAFYATEDDRFILKQMPRLEVQ 1896

  Fly  1602 IFEPFAPKYFEYIDRCQQQQQPTLLAKIFGVFRVSVKKKDSFVER--SVMVMENLFYGCNIENKF 1664
            .|..|||.||.||....||::||.||||.||:|:..|...:..|:  .::||||||||..:...|
Mouse  1897 SFLDFAPHYFNYITNAVQQKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVMENLFYGRKMAQVF 1961

  Fly  1665 DLKGSERNRLV--DPSNQQGEIVLLDENLVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVM 1727
            |||||.|||.|  |...:..::|||||||::|....|||:.||||:|||.:|..|:.||..:|::
Mouse  1962 DLKGSLRNRNVKTDTGKESCDVVLLDENLLKMVRDNPLYIRSHSKSVLRTSIHSDAHFLSSHLII 2026

  Fly  1728 DYSLLVGLDKKNGVLVLGIIDYIRTFTLDKRVESIIKGSGILGGKGKDPTVVNPERYKQRFIDAM 1792
            |||||||.|..:..||:||||||||||.||::|.::|.:|||||:||.||||:||.|:.||.:||
Mouse  2027 DYSLLVGRDDTSNELVVGIIDYIRTFTWDKKLEMVVKSTGILGGQGKMPTVVSPELYRTRFCEAM 2091

  Fly  1793 DRYFLTVPDRWEGL 1806
            |:|||.|||.|.||
Mouse  2092 DKYFLMVPDHWTGL 2105

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fab1NP_611269.1 FYVE_PIKfyve_Fab1 182..243 CDD:277264 42/60 (70%)
DEP 329..397 CDD:214489 23/125 (18%)
Fab1_TCP 464..717 CDD:239450 109/260 (42%)
PIPKc 1413..1797 CDD:295374 160/425 (38%)
PikfyveXP_006495839.1 FYVE_PIKfyve_Fab1 166..227 CDD:277264 42/60 (70%)
DEP_PIKfyve 369..450 CDD:239895 18/82 (22%)
Fab1_TCP 629..889 CDD:239450 109/260 (42%)
PIPKc_PIKfyve 1829..2095 CDD:340437 139/320 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167835163
Domainoid 1 1.000 260 1.000 Domainoid score I1970
eggNOG 1 0.900 - - E1_COG5253
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H32115
Inparanoid 1 1.050 710 1.000 Inparanoid score I641
Isobase 1 0.950 - 0 Normalized mean entropy S5320
OMA 1 1.010 - - QHG58433
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003143
OrthoInspector 1 1.000 - - oto95319
orthoMCL 1 0.900 - - OOG6_101979
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2108
SonicParanoid 1 1.000 - - X2110
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.640

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