Protein Alignment fab1 and ppk-3

DIOPT Version :10

• Sequence 1: NP_611269.1
• Gene: fab1 / 37033
• FlyBaseID: FBgn0028741
• Length: 1809
• Species: Drosophila melanogaster
• Sequence 2: NP_001391085.1
• Gene: ppk-3 / 181428
• WormBaseID: WBGene00004089
• Length: 1500
• Species: Caenorhabditis elegans
• Alignment Length: 1865
• Identity: 489/1865 - (26%)
• Similarity: 779/1865 - (41%)
• Gaps: 507/1865 - (27%)

  Fly    77 QFFS--DSQTSTAEIADVETSS------------QSSVRPQP----PTTLSIRTNSETRGTSTSS 123
            |||.  :....|.|...|..||            :|...|||    |.| ..|.|.|
 Worm     8 QFFEKLEPPPETEEPTPVSVSSGGYFSNIIGQIFRSDGSPQPNGVVPPT-EERQNLE-------- 63

  Fly   124 NTAAEDSETSDRVETLPLPTSEANQGRTVSNVLKHISNIVATKNNNDLRNYKDTELQRFWMPDSK 188
            .|.:.:|.||:          |:...|::::   ..:.::.:|.|..|::|.|:..:::|||||.
 Worm    64 RTESGESRTSE----------ESGFQRSLTD---KFTGLLKSKVNPQLKDYNDSNFKQYWMPDST 115

  Fly   189 AKECYDCSQKFSTFRRKHHCRLCGQIFCSKCCNQVVPGMIIRCDGDLKVCNYCSKIVLTFLKS-- 251
            .:|||.|.::|:||||:|||||||||||:|||:..:.|..:...|:|::|:||::.|....:.
 Worm   116 GRECYQCEERFTTFRRRHHCRLCGQIFCAKCCSSHIDGAALGYMGELRLCDYCARKVQRLAEEGK 180

  Fly   252 --------------SSSEMGQDMQELQQHLSNKLEVQDSGSSLAKHPQMQRAPLPRKTSVGYQEE 302
                          :|.::..|.....:: |:.:....:|:..:..|.....| |..||
 Worm   181 QTPTTSTTRSQTPVNSRKISFDRNTAHKN-SDTVRTVSNGAIWSLCPPESSMP-PEITS------ 237

  Fly   303 RFSSHPTYTTLSIDDRKNILQQSNSLITLHEEMQRDLPAQNCGQRLIEFLNSNNKSANEVQAVAI 367
                 |.    .:..|:|.|.||                            ||......:.:||.
 Worm   238 -----PP----QLGSRRNSLAQS----------------------------SNGPGVPTILSVAD 265

  Fly   368 L----NAMLAAGFLEPIVPDPEQM--DFDSSLHYKFSKSSSSDTSRTMSPQFEAN---------- 416
            |    :|||......|::.:.|:.  |:..::|.......:::||.:......||
 Worm   266 LCASNSAMLTNSHSHPMITEEEESGPDWFRTMHPGMDGVINNETSDSADVFAYANLAGAITNEFT 330

  Fly   417 -----PHAEPQ----------PPKSMDQS----AEEKEKELENELENDRCYTTATSKLLASYCEH 462
                 ..|||.          |..|:|:|    |:|::::...||                :..:
 Worm   331 EMMDARAAEPTSATTDRKITFPSLSLDESVMNAAKEEQRDNLEEL----------------FRRN 379

  Fly   463 EEQLLAQ-MLRAHNLDQEW-DKVLQMLCSTAANHFKPEHCSNDLMDIRNYVNFKKVPGGRRK-DS 524
            .|::|.: |.|.:..:.:| |.:|:.:.....| ......|.|.|:|.:||:.|||.....| ||
 Worm   380 TERILDEVMKREYIREDKWRDLILKSVYEVVEN-VTVNVPSGDTMNIADYVHVKKVHKKEGKVDS 443

  Fly   525 KIVHGVAFSKNVAHK-----DMATHVPFPRILLLQCPIVYERIEGKFVTIETVLLQEKEYLRNVC 584
            :|:.|||.|:::.:|     |.::|.. ..|:::...|.|||:..|..:||.:::||:::|....
 Worm   444 EIIWGVACSRSLVYKSLSEEDESSHTT-ESIMIVSGSIEYERVSNKLSSIEPIIVQEEKFLEKQI 507

  Fly   585 ARIMSFKPNVVLVHKNVAGIAQDLLRSYEVTLVLDVKLSVMERLSRTLQCDIVSSIESNITMPKL 649
            .||.:.:.:::||...|:.||..||....:.:.::||:|:::|:||....||||:.:|.:....|
 Worm   508 DRIATKRASLILVEGGVSHIAAQLLHKRGIKVAVNVKMSILQRISRATGADIVSNSDSQLVEQNL 572

  Fly   650 GYCNDFYIRNYNG-----KTLMFFEKLTNPRGYTCLLRGGSNAELTRVKRVASALLFARYNWRLE 709
            |.|.:|..||...     ||||.|.......|.|.||.|....||..||||...|:...|:..||
 Worm   573 GCCPEFQQRNMQQEDGRIKTLMIFADCQKETGCTVLLHGDDLKELVAVKRVVQFLVTIVYSNYLE 637

  Fly   710 MSFLLNEFAQPLSPKPSIFDSKETSPKTETEAELRSKRPIILERKSEDKITTIVSENVSDFTDPL 774
            .|: ||.|             ..|..:.:::..:..||..|:..:.|
 Worm   638 QSY-LNAF-------------NTTIARRQSDCVVCEKRRAIVYSQGE------------------ 670

  Fly   775 RASQAEALSTSPCAPPVVEALAVEPRYDNRFRTALSSTLLSVSPFLTFPLPYLETEQGRKCKLRK 839
                                       ...|...|.:|:||.||.:.|..|.|||..||:|.|..
 Worm   671 ---------------------------KTEFEKNLYATMLSSSPVIEFEPPLLETATGRECPLIA 708

  Fly   840 LFPAELYFSKQWSRTGLERPDSMGDGE---AGKSE---PGNKENQMQLLPAHDFVLMKITAPASS 898
            .|...||        .|.:|   ||.|   .|..|   |..|:..:.:...|.|      |..:.
 Worm   709 YFKQPLY--------KLLKP---GDVELIKQGYEEDIVPIPKKEPLLVDRRHAF------AQCNR 756

  Fly   899 RDIQSKLA-EFRSFGGRLPKGKAPMLRPKKKNAEVIQRPQKV-SEEQLY--KDALDPQNHQRLPV 959
            ..|...:| .||.|||         :..:::.|::::..:.| :|:|.:  ||.|||:.||.|.|
 Worm   757 GAILDNVARSFRLFGG---------INFRRRTAQIVKHRKIVETEKQPFRAKDVLDPRVHQTLAV 812

  Fly   960 LFCSFHYNPKGVSSFCKLPMLLDMKFYGQYDIMLEQFLQRYCCLFNSMCPS--CNLPMLGHVRRY 1022
            ||.||.........||..|.::.|::|..:|:.:.:||.::|...:..|||  |.:|||.|.|:.
 Worm   813 LFGSFSRKSPNAPYFCVRPWVVSMQYYKDHDMTIGEFLVKFCFNRSYECPSSNCEVPMLDHSRKL 877

  Fly  1023 VHSLGCVHVYL-----TEDLTRSDPTRIYFTSW--CSICNATTPTIPLSDAAKCLSLAKYLEMRF 1080
            |:...||.:..     .|:...|:..:...| |  |..||.::..:....|...||.||:||  :
 Worm   878 VYGKVCVEISTQTVNEAENAIESEQQKSIMT-WRNCGKCNCSSQMVKFDKAIWHLSFAKFLE--Y 939

  Fly  1081 HGHA-------YKRRPPSTDAEQGGTVCEHSLHRDYVHHFSFRGVGAKFQYTPVEVWETDLPSLT 1138
            .|::       |    |.|:..|    |.|....:.::.|:...:...|:...:.
 Worm   940 IGNSCFTTDTIY----PITNQNQ----CSHCFFHEKLYFFAMDNLVTTFKVIAIR---------- 986

  Fly  1139 VQLDLPQPFQSAQVQEEIKNFSIKGHEVYNRIHERIADL---ATEEENSPLVQHLKTMLTHDQFI 1200
                 |.....:.:...:|...:...|:.:.: .|||.|   |.|:.|..|.:
 Worm   987 -----PYSVVFSPIICSVKVLKVSRKELSDDV-SRIATLALTACEDTNKQLAE------------ 1033

  Fly  1201 FKQKIEIVHTLLTDNRATAYDTSDALAMARRALAESIELWGPRLQEIEKLTAKQAHHIDSGTICT 1265
            ..::::|  |.:....|.|...:.|||...|..|::|.                     ||
 Worm  1034 LDEEVQI--TPIVVKLAGAIRNTMALASESRMFAKNIL---------------------SG---- 1071

  Fly  1266 EELRPEQVQTADSSKVTTSSLPKENDPLECPSEDTETGASNSQTVLDKNFSIDQMLASTVNVYSD 1330
                             ...|.:.||.|             .:.|......:.::..:.:.::::
 Worm  1072 -----------------DEDLIRSNDRL-------------YREVTGTFMKVREVTYNLIALWNE 1106

  Fly  1331 K-----------KSIRKILTQLLPSGNQVNPLQSPFPAQDHLTLP----LGSIPIHVRET----- 1375
            .           :.|::|.|        :..|::|||:..||.:.    ||.:...:::|
 Worm  1107 NCAAIKYPKRTPEDIQEIAT--------LQKLENPFPSHLHLAIKLQPRLGVVVRDIQDTRGNFK 1163

  Fly  1376 -DLSSVIAYSLTSMDYQKAIDEAEANSNAAHSSPQLKRKIPLAESVSDAEDSPSLSRTSSNTSAA 1439
             |:.|:|||:|:::||.| |.||....:...:|..||        .|..:|..:|:
 Worm  1164 PDIGSIIAYALSAVDYNK-IPEAADTVSMDSASSSLK--------FSQMDDGENLA--------- 1210

  Fly  1440 PNASVPSPATAASESEEKSKERIKQPPSPHITLAFQDHSCQFQCKIYFAREFDAMRSKSLKPPKL 1504
                                      .|.|:.:.|:|.|..:..|:.:|.:|..:|
 Worm  1211 --------------------------SSQHLEVEFEDESASYYVKMLYAEKFRKLR--------- 1240

  Fly  1505 DKSLYRRLEKSKMREELRISQSRTGSEMELVRKPSDVGAPRTTEDDSNQEEDARIALARSLCKSV 1569
                           ||.|::   |.|                            ...|||..|.
 Worm  1241 ---------------ELLIAE---GEE----------------------------TFIRSLSNST 1259

  Fly  1570 QWEARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRCQQQQQPTLLAKIFGVFR 1634
            .|..:||||||.|.:|.|||||:|:|:..::..|..|||.||:|:.....:.:.|.|.|::||||
 Worm  1260 FWTPQGGKSGSFFYRTQDDRFVVKQMSRFEIQSFVKFAPNYFDYLTTSATESKLTTLCKVYGVFR 1324

  Fly  1635 VSVKKKDSFVERSVMVMENLFYGCNIENKFDLKGSERNRLVDPSNQQGEIVLLDENLVQMSWSKP 1699
            :..|.|.:.::..::|||.|||..|:...:|||||.||||........|:||||||.|:..|::.
 Worm  1325 IGYKSKTTTLKVDILVMEYLFYNHNVSQVWDLKGSLRNRLASTGKSANEMVLLDENFVKDLWNQQ 1389

  Fly  1700 LYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSLLVGLDKKNGVLVLGIIDYIRTFTLDKRVESIIK 1764
            ||||.|||..:..||..||.||....:||||||||:|..||.|:|||:||:||:||||::||.:|
 Worm  1390 LYVLPHSKAAMNQAISNDSHFLSSQYIMDYSLLVGVDDDNGELILGIVDYMRTYTLDKKLESWVK 1454

  Fly  1765 GSGILGGKGKDPTVVNPERYKQRFIDAMDRYFLTVPDRWEGLSKV 1809
            ...|.|  ...||:::||.|..||.:|:|.||..|||:|.||..:
 Worm  1455 IVAIPG--AHLPTILSPEMYCARFSEAIDSYFPVVPDQWTGLGSI 1497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264	34/60 (57%)
		DEP	329..397	CDD:214489	12/73 (16%)
		Fab1_TCP	464..717	CDD:239450	88/265 (33%)
		PIPKc_PIKfyve	1479..1796	CDD:340437	120/316 (38%)
ppk-3	NP_001391085.1	FYVE_PIKfyve_Fab1	109..170	CDD:277264	34/60 (57%)
		Fab1_TCP	381..645	CDD:239450	89/279 (32%)
		PIPKc_PIKfyve	1224..1484	CDD:340437	120/316 (38%)