DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fab1 and lst-2

DIOPT Version :9

Sequence 1:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	NP_508756.2	Gene:	lst-2 / 180712	WormBaseID:	WBGene00003084	Length:	661	Species:	Caenorhabditis elegans

Alignment Length:	290	Identity:	73/290 - (25%)
Similarity:	106/290 - (36%)	Gaps:	105/290 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NNSSSHQHLHSPSKLTEFARNFEDKPESLFGRVVNKIQNVYNQSYNTVNDISSGS---------- 61
            |::||::...||..:.|  .:..|..||....|...|....|:|.:.:.|....|
Worm   382 NSNSSNEVTESPETIEE--PDNVDMEESSESEVDTHIDETRNESDDEITDDVQASDVLQVETKKC 444

  Fly    62 ------------SSSSSTQPVQVVGKSQF--------FSDSQ-------TSTAEIAD-VETSSQS 98
                        .|..:..|:|...:||.        |..|:       ...|.:|| ::|:..|
Worm   445 KSSRLLEQKKFDKSVKTIIPMQTDPRSQIDPKNLRSRFRSSEDLVHRLFVCIAGVADQLQTNYSS 509

  Fly    99 SVRP------QPPTTLSIR-------TNSETRGTSTSSNTAAEDSETSDRVETLPLPTSEANQGR 150
            .:|.      ||...:.:.       .||:|.|..|.          .:..||||||   |..|
Worm   510 EIRKVLKLILQPSEIIPVYEVVNAQVANSQTEGEETG----------VEAQETLPLP---AFMG- 560

  Fly   151 TVSNVLKHISNIVATKNNNDLRNYKDTELQRFWMPDSKAKECYDCSQKFSTFRRKHHCRLCGQIF 215
                                :|          |:||...::|..||..|:..||:||||.||:||
Worm   561 --------------------VR----------WVPDEDCEQCTACSMPFNFVRRRHHCRNCGRIF 595

  Fly   216 CSKC-CNQV-VP--GMIIRCDGDLKVCNYC 241
            |.|| ||.: :|  |.    |..::|||.|
Worm   596 CHKCSCNTISIPEHGY----DRKVRVCNLC 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264	29/64 (45%)
		DEP	329..397	CDD:214489
		Fab1_TCP	464..717	CDD:239450
		PIPKc	1413..1797	CDD:295374
lst-2	NP_508756.2	SDA1	<361..>453	CDD:283052	15/72 (21%)
lst-2	NP_508756.2	FYVE_LST2	559..623	CDD:277270	31/98 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2108
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940