DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fab1 and pip5kl1

DIOPT Version :9

Sequence 1:	NP_611269.1	Gene:	fab1 / 37033	FlyBaseID:	FBgn0028741	Length:	1809	Species:	Drosophila melanogaster
Sequence 2:	XP_002935545.2	Gene:	pip5kl1 / 100490940	XenbaseID:	XB-GENE-986827	Length:	504	Species:	Xenopus tropicalis

Alignment Length:	403	Identity:	84/403 - (20%)
Similarity:	147/403 - (36%)	Gaps:	125/403 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1365 LGSIPIHVRETDLSSVIAYSLTSMDYQKAIDEAEANSNAAH-----SSPQLKRKIPLAESVSDAE 1424
            :|.:..|..:   ::.|....::.|.::|:.|.|:..:..|     :..|..:.:.|.|...:.|
Frog    42 VGQVLCHPLQ---AAEIPMEQSTKDEREAMPEGESRQSTRHRRLFWNLRQRWKLLGLFEIDQEHE 103

  Fly  1425 DSPSLSRTSSNTSAAPNASVPSPATAASESEEKSKERIKQPPSPHITLAFQDHSCQFQCKIYFAR 1489
            ..|                      ...:.::..|:.|::......|:|..|..  :..||....
Frog   104 FYP----------------------LTCDLKQGLKQAIQESIHSDTTIALADEG--YSAKITQGH 144

  Fly  1490 EFDAMRSKSLKPPKLDKSLYRRLEKSKMREELRISQSRTGSEMELVRKPSDVGAPRTTEDDSNQE 1554
            |...||:            |.....|..|:.|.||:.
Frog   145 EGFVMRT------------YAGPVFSHFRQSLGISEE---------------------------- 169

  Fly  1555 EDARIALARSL-CKSVQWE-ARGGKSGSRFCKTLDDRFVLKEMNSRDMTIFEPFAPKYFEYIDRC 1617
                 :..:|| |.....: ....||.:.|..|.|.||.||....|:.........:|.|:.
Frog   170 -----SFTKSLSCNEFYLQFISNSKSKADFFLTNDKRFFLKTQTKREAHFMLQILRRYIEHF--- 226

  Fly  1618 QQQQQPTLLAKIFGVFRVSV--KKKDSFVERSVMVMENLFY-GCNIENKFDLKGSERNRLVDPS- 1678
             |....:||.||.||:.::.  .||..|:     :|:::|: ...|.:::|:||.:.:|..:|.
Frog   227 -QLYPHSLLVKILGVYSITYAQNKKKYFI-----IMQSVFFPDERITSRYDIKGCKVSRWTEPEP 285

  Fly  1679 ------------NQQGEIVLLDENLVQMSWSKPLYVLSHSKTVLRDAIQRDSSFLEKNLVMDYSL 1731
                        |.:|.::.||:   |.:|             |...::.|:|||::..|:||||
Frog   286 EGSRVLQVFKDCNFEGNVICLDQ---QRAW-------------LLLQMELDASFLQQLNVIDYSL 334

  Fly  1732 LVGL-----DKKN 1739
            |||.     |:||
Frog   335 LVGFQPLHADEKN 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fab1	NP_611269.1	FYVE_PIKfyve_Fab1	182..243	CDD:277264
		DEP	329..397	CDD:214489
		Fab1_TCP	464..717	CDD:239450
		PIPKc	1413..1797	CDD:295374	75/350 (21%)
pip5kl1	XP_002935545.2	PIPKc_PIP5KL1	102..502	CDD:340441	73/340 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910