DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5009 and Acox2

DIOPT Version :9

Sequence 1:	NP_611264.2	Gene:	CG5009 / 37028	FlyBaseID:	FBgn0027572	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_001155139.1	Gene:	Acox2 / 93732	MGIID:	1934852	Length:	681	Species:	Mus musculus

Alignment Length:	679	Identity:	248/679 - (36%)
Similarity:	366/679 - (53%)	Gaps:	31/679 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AKPVNPDLQKERSTATFNPREFSVLWAGGEERFKEKKALEKLFLEDPALQDDLP-ISYLSHKELY 66
            ::.|:||:..||.:.:|:....:.:..||....:.::.:|.|...||..  :|. :.:::..|||
Mouse    15 SREVHPDIDSERHSPSFSVERLTNILDGGIPNTELRRRVESLIQRDPVF--NLKHLYFMTRDELY 77

  Fly    67 EHSLRKACIIGEKIRKLRADGEDGVDTYNALLGGSLGSAILKEGNPLALHYVMFVPTIMGQGTMD 131
            |.:::|...: ||:.......|||.:...|       ..:|...|.|.||.:. :..|...|:.:
Mouse    78 EDAVQKRFHL-EKLAWSLGWSEDGPERIYA-------DRVLAGYNNLNLHGIA-MNAIRSLGSDE 133

  Fly   132 QQVEWLSKAWDCEIIGTYAQTELGHGTFLRGLETRADYDASTQEFVINTPSLSAYKWWPGGLGHT 196
            |..:|.....:.:||.|||||||||||:|:||||.|.|||:||||||::|::::.|||||.||.|
Mouse   134 QIAKWGQLGKNFQIITTYAQTELGHGTYLQGLETEATYDATTQEFVIHSPTMTSIKWWPGDLGRT 198

  Fly   197 ANHAVVVAQLYTKGEFRGLAPFIVQLRDSDTHRPMPGIDIGDIGTKLGMKGVNNGYLGLKNVRVP 261
            ..||||:|.|...|...|:..|||.:|..:.|.|:|||.:||||.|:|.:.::||:|.|.:||||
Mouse   199 VTHAVVLAHLICLGARHGMHAFIVPIRSLEDHTPLPGITVGDIGPKMGFENIDNGFLRLNHVRVP 263

  Fly   262 LNNMLMKNQQVLPDGTYVAPKNSVLTYGTMMFVRCALI-RDTAQSLAKASTIATRYSAVRRQSPI 325
            ..|||.:..:|||||||.........|..|:..|..|: :....:|.||.|||.||:.:|.||.:
Mouse   264 RENMLSRFAEVLPDGTYQRLGTPQSNYLGMLVTRVQLLYKGFLPTLQKACTIAVRYAVIRHQSRL 328

  Fly   326 DPNQPEPQIMDHTTQQLKLFPQIA--KAIVFKTTGDGIWNMYNVISGEIEQGNLDRLPEMHALSC 388
            .|:.||.:|:::.|||.||.||:|  .|:.|.||  .:...::....:|.:.:...|||:||||.
Mouse   329 RPSDPEAKILEYQTQQQKLLPQLAVSYALHFMTT--SLLQFFHSSYSDILKRDFSLLPELHALST 391

  Fly   389 CLKAICSADAAAGVETCRLSCGGHGYMDCSNFPTIYGMTTAVCTYEGENTVMLLQTARYLVKVYG 453
            .:||:.|...|.|.|.||.:||||||...|..||:.....|.|||||||||:.||.||:|:|.|.
Mouse   392 GMKAMSSDFCAQGTEICRRACGGHGYSKLSGLPTLVTQAIASCTYEGENTVLYLQVARFLMKSYL 456

  Fly   454 QALNGEKLVP------TVSYISDAINQTKFVNFDGSLRS---IVKAFQFVAANKTRIAYEQIELR 509
            ||......:|      :|.|::...............|.   ...|:.:|:|...|.|.:..:..
Mouse   457 QAQVSPGSIPQKPLPQSVMYLATPRPARCPAQTAADFRCPEVYTTAWAYVSARLIRDATQHTQTL 521

  Fly   510 RKQGYGTEVAANLCGTFLTAAADLHGRAFLAQTAYTELL-ALSREVSPELAEVLKVVLELYLVDA 573
            .:.|.....|.|........||..| ..||....:.|.: .|..|  ||:..||:.:.:||.::.
Mouse   522 MRSGVDQYDAWNQTSVIHLQAAKAH-CYFLTVRNFKEAVEKLDNE--PEIQRVLQNLCDLYALNG 583

  Fly   574 CLNRIGDFLRFIDLTDQDVTKLEVRLENCLKRFRPNAVSLVDSFDLHDRVLDSALGAYDGNVYEH 638
            .|...||||....|:...|........:.|...|.:|:.|.|:||..|..|:||||.|||:||:.
Mouse   584 ILTNSGDFLHDGFLSGAQVDMARTAFLDLLPLIRKDAILLTDAFDFSDHCLNSALGCYDGHVYQR 648

  Fly   639 IFESTKKNPLNKEPVNGAFHKYLKPFMKA 667
            :||..:|:|.|.:. |.|:.||::|.|::
Mouse   649 LFEWAQKSPANTQE-NPAYKKYIRPLMQS 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5009	NP_611264.2	AXO	8..645	CDD:173839	238/650 (37%)
CG5009	NP_611264.2	PLN02443	10..669	CDD:178062	245/672 (36%)
Acox2	NP_001155139.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		5/12 (42%)
		AXO	20..655	CDD:173839	238/650 (37%)
		Microbody targeting signal. /evidence=ECO:0000255	679..681
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845542
Domainoid	1	1.000	151	1.000	Domainoid score	I4331
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54939
OrthoDB	1	1.010	-	-		D203634at33208
OrthoFinder	1	1.000	-	-		FOG0001030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100457
Panther	1	1.100	-	-	O	PTHR10909
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X618
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.760