DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5009 and ACOX2

DIOPT Version :9

Sequence 1:	NP_611264.2	Gene:	CG5009 / 37028	FlyBaseID:	FBgn0027572	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_003491.1	Gene:	ACOX2 / 8309	HGNCID:	120	Length:	681	Species:	Homo sapiens

Alignment Length:	683	Identity:	246/683 - (36%)
Similarity:	365/683 - (53%)	Gaps:	39/683 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AKPVNPDLQKERSTATFNPREFSVLWAGGEERFKEKKALEKLFLEDP--ALQDDLPISYLSHKEL 65
            ::.::||::.||...:|:....:.:..||.:....::.:|.:....|  :.:|:.   :::..|.
Human    15 SRQMHPDIESERYMQSFDVERLTNILDGGAQNTALRRKVESIIHSYPEFSCKDNY---FMTQNER 76

  Fly    66 YEHSLRKACIIGEKIRKL--RADGEDGVDTYNALLGGSLGSAILKEGNPLALHYVMFVPTIMGQG 128
            |:.::|:|..|....|:|  ..||.:....|.||.|..          .|.:|.| ||..:...|
Human    77 YKAAMRRAFHIRLIARRLGWLEDGRELGYAYRALSGDV----------ALNIHRV-FVRALRSLG 130

  Fly   129 TMDQQVEWLSKAWDCEIIGTYAQTELGHGTFLRGLETRADYDASTQEFVINTPSLSAYKWWPGGL 193
            :.:|..:|.....:.:||.|||||||||||:|:||||.|.|||:||||||::|:|:|.|||||.|
Human   131 SEEQIAKWDPLCKNIQIIATYAQTELGHGTYLQGLETEATYDAATQEFVIHSPTLTATKWWPGDL 195

  Fly   194 GHTANHAVVVAQLYTKGEFRGLAPFIVQLRDSDTHRPMPGIDIGDIGTKLGMKGVNNGYLGLKNV 258
            |.:|.||:|.|||...|..||:..|||.:|....|.|:|||.|||||.|:.....:||:|.|.:|
Human   196 GRSATHALVQAQLICSGARRGMHAFIVPIRSLQDHTPLPGIIIGDIGPKMDFDQTDNGFLQLNHV 260

  Fly   259 RVPLNNMLMKNQQVLPDGTYVAPKNSVLTYGTMMFVRCALIR-DTAQSLAKASTIATRYSAVRRQ 322
            |||..|||.:..|||||||||....:...|..|:.||..|:. :....|.||..||.|||.:|||
Human   261 RVPRENMLSRFAQVLPDGTYVKLGTAQSNYLPMVVVRVELLSGEILPILQKACVIAMRYSVIRRQ 325

  Fly   323 SPIDPNQPEPQIMDHTTQQLKLFPQIAKAIVFKTTGDGIWNMYNVISGEIEQGNLDRLPEMHALS 387
            |.:.|:.||.:::|:.|||.|||||:|.:..|......:...:......|...:...|||:||||
Human   326 SRLRPSDPEAKVLDYQTQQQKLFPQLAISYAFHFLAVSLLEFFQHSYTAILNQDFSFLPELHALS 390

  Fly   388 CCLKAICSADAAAGVETCRLSCGGHGYMDCSNFPTIYGMTTAVCTYEGENTVMLLQTARYLVKVY 452
            ..:||:.|.....|.|.||.:||||||...|..|::....:|.|||||||||:.||.||:|||.|
Human   391 TGMKAMMSEFCTQGAEMCRRACGGHGYSKLSGLPSLVTKLSASCTYEGENTVLYLQVARFLVKSY 455

  Fly   453 GQ------ALNGEKLVPTVSYIS-------DAINQTKFVNFDGSLRSIVKAFQFVAANKTRIAYE 504
            .|      :.....|.|:|:|::       .|.....|:    .......|:..||....:.:.:
Human   456 LQTQMSPGSTPQRSLSPSVAYLTAPDLARCPAQRAADFL----CPELYTTAWAHVAVRLIKDSVQ 516

  Fly   505 QIELRRKQGYGTEVAANLCGTFLTAAADLHGRAFLAQTAYTELLALSREVSPELAEVLKVVLELY 569
            .::...:.|.....|.|........||.:| ..::....:||.|. ..|..|.:.:|||.:.:|:
Human   517 HLQTLTQSGADQHEAWNQTTVIHLQAAKVH-CYYVTVKGFTEALE-KLENEPAIQQVLKRLCDLH 579

  Fly   570 LVDACLNRIGDFLRFIDLTDQDVTKLEVRLENCLKRFRPNAVSLVDSFDLHDRVLDSALGAYDGN 634
            .:...|...||||....|:...|........:.|:..|.:|:.|.|:||..|:.|:||||.||||
Human   580 AIHGILTNSGDFLHDAFLSGAQVDMARTAYLDLLRLIRKDAILLTDAFDFTDQCLNSALGCYDGN 644

  Fly   635 VYEHIFESTKKNPLNKEPVNGAFHKYLKPFMKA 667
            |||.:|:..:|:|.|.:. |.|:.:|::|.:::
Human   645 VYERLFQWAQKSPTNTQE-NPAYEEYIRPLLQS 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5009	NP_611264.2	AXO	8..645	CDD:173839	239/654 (37%)
CG5009	NP_611264.2	PLN02443	10..669	CDD:178062	244/676 (36%)
ACOX2	NP_003491.1	ACAD	20..655	CDD:324545	239/654 (37%)
ACOX2	NP_003491.1	Microbody targeting signal. /evidence=ECO:0000255	679..681
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155079
Domainoid	1	1.000	151	1.000	Domainoid score	I4347
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54939
OrthoDB	1	1.010	-	-		D203634at33208
OrthoFinder	1	1.000	-	-		FOG0001030
OrthoInspector	1	1.000	-	-		mtm8477
orthoMCL	1	0.900	-	-		OOG6_100457
Panther	1	1.100	-	-	O	PTHR10909
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X618
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.760