DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5009 and acox3

DIOPT Version :9

Sequence 1:	NP_611264.2	Gene:	CG5009 / 37028	FlyBaseID:	FBgn0027572	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_998312.1	Gene:	acox3 / 406421	ZFINID:	ZDB-GENE-040426-2163	Length:	692	Species:	Danio rerio

Alignment Length:	729	Identity:	213/729 - (29%)
Similarity:	328/729 - (44%)	Gaps:	109/729 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAKPVNPDLQKERSTATFNPREFSVLWAGGE-ERFKEK--KALEK--LFLEDPALQDDLPI--- 57
            :|..|..| |...|..|:|:.::......|.| ..||:.  :.||.  ||...|.  :|:|:
Zfish     5 IPDFPNGP-LDIYRKKASFSWKDMMRFLEGDELIAFKQHVFRTLESDPLFARQPG--EDVPVEQK 66

  Fly    58 ---SYLSHKELYEHSLRKACIIGEKIRKLRADGEDGVDTYNALLG--------------GSLGSA 105
               ::|..|:|:::..    |..|::.:    ....:...|..||              |..|:.
Zfish    67 RELTFLRCKQLFKYDF----ITREELMQ----NPWKMTVLNDCLGMYDWSLCAKYFLNKGMFGAT 123

  Fly   106 ILKEGNPLALHYVMFVPTIMGQGTMDQQVEWLSKAWDCEIIGTYAQTELGHGTFLRGLETRADYD 170
            ::..|:...|.:|..:..:|                   ..|.::.|||.||:..|.|.|.|.||
Zfish   124 VVNTGSQRHLKFVKDIERMM-------------------TFGCFSLTELSHGSNTRALRTTAKYD 169

  Fly   171 ASTQEFVINTPSLSAYKWWPGGLGHTANHAVVVAQLYT-KGEFRGLAPFIVQLRDSDTHRPMPGI 234
            .:|||||||:|...|.|:|.|.||.||.|:||.||||| .|:..||..||||:||..|...|||:
Zfish   170 PNTQEFVINSPDFEAAKFWVGNLGKTATHSVVFAQLYTPDGKCHGLHSFIVQVRDPKTLLAMPGV 234

  Fly   235 DIGDIGTKLGMKGVNNGYLGLKNVRVPLNNMLMKNQQVLPDGTYVAP-----KNSVLTYGTMMFV 294
            .:||:|.|||..|::||:....|||:|..|:|.|...|.|||.||:|     |....:.|.:...
Zfish   235 MVGDMGKKLGQNGLDNGFAVFHNVRIPRENLLNKTGDVAPDGQYVSPFKDPNKRFGASLGALSGG 299

  Fly   295 RCALIRDTAQSLAKASTIATRYSAVRRQSPIDPNQPEP-QIMDHTTQQLKLFPQIAKAIVFK-TT 357
            |..:.|....:|..|.|:|.|:||.|||  ..|.:.|. .::::..||.:|.|.:|.....: .|
Zfish   300 RVGITRMALVNLKLAVTVAVRFSATRRQ--FGPKEDEEIPVLEYQLQQWRLIPFLAAVYALEHFT 362

  Fly   358 GDGIWNMYNVISGEIEQGNLDRLPEM----HALSCCLKAICSADAAAGVETCRLSCGGHGYMDCS 418
            .....|......|.:.:...||..|:    |||||..|.:.|..|..|::.||.:||||||:..:
Zfish   363 KSFSMNFVEFQMGLLMKDKSDRQAELGREIHALSCASKPLGSWTAQRGIQECREACGGHGYLAMN 427

  Fly   419 NFPTIYGMTTAVCTYEGENTVMLLQTARYLVKVYGQALNG----EKLVPTVSYISD--AINQTKF 477
            ....:.......|||||:|.|:|.||:.||:........|    |..:.||:::.|  :|.|:||
Zfish   428 RLGDMRDDNDPNCTYEGDNNVLLQQTSNYLLSWIQHKQEGKGRIESPLETVNFLDDMSSILQSKF 492

  Fly   478 VNFDGSLRSIVKAFQFVAANKTRIAYEQIELRRK------QGYGTEVAANLCGTFLTAAADLHGR 536
            .  .||:...:.:...:||.|..:.:...|.::|      .|.|...|.|....:...:..:
Zfish   493 T--VGSVEECMNSAVPLAAYKWLVCFLLGESQKKLFEEKSSGLGDFEARNNSQVYYCRSLAI--- 552

  Fly   537 AFLAQTAYTEL--LALSREVSPELAEVLKVVLELYLVDACLNRI-----GDFLRFIDLTDQDVTK 594
            ||:..|.....  |....:....|..||..:..||.:....|.:     |.:..    ..|.|..
Zfish   553 AFIEHTVLQRFHDLIQDEQTPAVLRSVLGRLCALYGLWTLTNHMAILYQGGYFS----GGQPVDF 613

  Fly   595 LEVRLENCLKRFRPNAVSLVDSFDLHDRVLDSALGAYDGNVYEHIFESTK--KNPLNK------- 650
            ::..:.....:.:.:||:|||.|...|.:|:|.:|..||.:|::::.:..  ||.|.:
Zfish   614 IQTAILTLCGQLKDDAVALVDVFAPPDFILNSPIGKSDGELYKNLWSTVMQGKNVLERPSWWAEF 678

  Fly   651 ---EPVNGAFHKYL 661
               :||.|:....|
Zfish   679 CSDKPVVGSLRAKL 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5009	NP_611264.2	AXO	8..645	CDD:173839	204/694 (29%)
CG5009	NP_611264.2	PLN02443	10..669	CDD:178062	210/720 (29%)
acox3	NP_998312.1	AXO	11..664	CDD:173839	204/693 (29%)
acox3	NP_998312.1	PLN02312	19..662	CDD:215178	201/682 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810