DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5009 and Acadvl

DIOPT Version :9

Sequence 1:	NP_611264.2	Gene:	CG5009 / 37028	FlyBaseID:	FBgn0027572	Length:	669	Species:	Drosophila melanogaster
Sequence 2:	NP_037023.1	Gene:	Acadvl / 25363	RGDID:	2014	Length:	655	Species:	Rattus norvegicus

Alignment Length:	642	Identity:	125/642 - (19%)
Similarity:	219/642 - (34%)	Gaps:	192/642 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SVLWAGGEERFKEKKALEKLFLE---DPALQDDLPISYLSHKELYEHSLRKACIIGEKIRKLRAD 86
            |||..|..:..||.......|.|   |||..|.|       :::.|.:|       :.:::|.|.
  Rat    92 SVLNEGQTQFLKELVGPVARFFEEVNDPAKNDSL-------EKVEEDTL-------QGLKELGAF 142

  Fly    87 G-----EDG----VDTYNALLGGSLGSAILKEGNPLALHYVMFVPTIMGQGTMDQQVEWLSKAWD 142
            |     |.|    .:|..|.|...:|...|.....|..|..:....|:..||..|:.::|.:...
  Rat   143 GLQVPSELGGLGLSNTQYARLAEIVGMHDLGVSVTLGAHQSIGFKGILLYGTKAQKEKYLPRVAS 207

  Fly   143 CEIIGTYAQTELGHGTFLRGLETRADYDASTQEFVINTP-----SLSAYKWW--PGGLGHTANHA 200
            .:.:..:..||...|:.:          ||.:...:.:|     :|:..|.|  .|||   |:..
  Rat   208 GQALAAFCLTEPSSGSDV----------ASIRSSAVPSPCGKYYTLNGSKIWISNGGL---ADIF 259

  Fly   201 VVVAQLYTKGEFRG-----LAPFIVQLRDSDTHRPMPGIDIGDIGTKLGMKGVNNGYLGLKNVRV 260
            .|.|:...|....|     :..|:|:       |...|:..|....|:|:|..|...:....|:|
  Rat   260 TVFAKTPIKDAATGAVKEKITAFVVE-------RSFGGVTHGLPEKKMGIKASNTSEVYFDGVKV 317

  Fly   261 PLNNMLMKNQQVLPDGTYVAPKNSVLTYGTMMFVRCALIRDTAQSLAKASTIATRYSAVRRQSPI 325
            |..|:|.:    :.||..||.  ::|..|               ....|:|:|....|:..::
  Rat   318 PAENVLGE----VGDGFKVAV--NILNNG---------------RFGMAATLAGTMKAIIAKA-- 359

  Fly   326 DPNQPEPQIMDHTTQQLK----------LFPQIAKAIVFKTTGDGIWNMYNVISGEIEQGNLDRL 380
                     :||.|.:.:          :..::|:..:.:...:   :|..::|..::||..|
  Rat   360 ---------VDHATNRTQFGDKIHNFGVIQEKLARMAILQYVTE---SMAYMLSANMDQGFKD-- 410

  Fly   381 PEMHALSCCLKAICSADAAAGV-ETCRLSCGGHGYMDCSNFPTIYGMTTAVCTYEGENTVMLLQT 444
               ..:...:..|..::||..| :.|....||.|:|.......:.........:||.|.::
  Rat   411 ---FQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPGVERVLRDIRIFRIFEGTNDIL---- 468

  Fly   445 ARYLVKVYGQALNGEKLVPTVSYISDAINQTKFVNFDGSLRSIVKAFQFVAANKTRIAYEQIELR 509
             |..|.:.|....|::|....:.:.:.:.....:                      |.....:||
  Rat   469 -RLFVALQGCMDKGKELTGLGNALKNPLGNVGLL----------------------IGEASKQLR 510

  Fly   510 RKQGYGTEVAANLCGTFLTAAADLHGRAFLAQTAYTELLALSREVSPELAEVLKVVLELYLVDAC 574
            |:.|.|:.                              |:||..|.||
  Rat   511 RRTGIGSG------------------------------LSLSGIVHPE----------------- 528

  Fly   575 LNRIGDFLRFIDLTDQDVTKLEVRLENCLKRFRPNAVSLVDSFDLHDRVLDSALGAY 631
            |:|.|:..  :...:|..|.:|.:|....|       .:|:...|..|:.|.|:..|
  Rat   529 LSRSGELA--VQALEQFATVVEAKLMKHKK-------GIVNEQFLLQRLADGAIDLY 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5009	NP_611264.2	AXO	8..645	CDD:173839	125/642 (19%)
CG5009	NP_611264.2	PLN02443	10..669	CDD:178062	125/642 (19%)
Acadvl	NP_037023.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70
		Catalytic. /evidence=ECO:0000250\|UniProtKB:P49748	41..482		97/468 (21%)
		VLCAD	72..481	CDD:173850	97/467 (21%)
		CaiA	100..473	CDD:224871	91/451 (20%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:P49748	461..463		0/1 (0%)
		Membrane-anchoring. /evidence=ECO:0000250\|UniProtKB:P49748	483..516		6/54 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810