DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH54F and TAL1

DIOPT Version :9

Sequence 1:	NP_477302.1	Gene:	HLH54F / 37027	FlyBaseID:	FBgn0022740	Length:	242	Species:	Drosophila melanogaster
Sequence 2:	NP_001274276.1	Gene:	TAL1 / 6886	HGNCID:	11556	Length:	331	Species:	Homo sapiens

Alignment Length:	192	Identity:	54/192 - (28%)
Similarity:	73/192 - (38%)	Gaps:	45/192 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RKKRSSSPTEFFDDDFDEDASSQSSQPPVQRNAANARERMRMRVLSSAYGRLKTKLPNIPPDTKL 67
            |.||..||       ::.:.:.......|:|...|:|||.|.:.::.|:..|:..:|..|||.||
Human   166 RVKRRPSP-------YEMEITDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKL 223

  Fly    68 SKLDTLRLATLYIKQLITAVETGSHSQNHPHNHNQHHSLNHSHSSTT--SSEGLDTSHMADSSGG 130
            ||.:.||||..||..|...                   ||......|  :..|.|....|...||
Human   224 SKNEILRLAMKYINFLAKL-------------------LNDQEEEGTQRAKTGKDPVVGAGGGGG 269

  Fly   131 GNYNFHNNGHGMSWPFEFHQSSRSLAFAPSSSTTSS----ARMDWQTLHTQSYPKTTRGETH 188
            |       |.|.:.|.:..|.    ..:|:||..||    |..|..|  .:..||.|....|
Human   270 G-------GGGGAPPDDLLQD----VLSPNSSCGSSLDGAASPDSYT--EEPAPKHTARSLH 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH54F	NP_477302.1	HLH	32..83	CDD:278439	22/50 (44%)
TAL1	NP_001274276.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..86
		HLH	193..243	CDD:197674	22/68 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..331		23/83 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810