DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH54F and ASCL1

DIOPT Version :9

Sequence 1:	NP_477302.1	Gene:	HLH54F / 37027	FlyBaseID:	FBgn0022740	Length:	242	Species:	Drosophila melanogaster
Sequence 2:	NP_004307.2	Gene:	ASCL1 / 429	HGNCID:	738	Length:	236	Species:	Homo sapiens

Alignment Length:	146	Identity:	42/146 - (28%)
Similarity:	66/146 - (45%)	Gaps:	26/146 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RKKRSSSPTEFFDD----DFDEDASSQSSQPPVQRNAANARERMRMRVLSSAYGRLKTKLPNIPP 63
            :::||||| |....    :|.....|...|.|......|.|||.|:::::..:..|:..:||...
Human    87 KRQRSSSP-ELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAA 150

  Fly    64 DTKLSKLDTLRLATLYIK---QLI-------TAVETGSHSQNHPHNHNQHHSLNHSHSSTTSSEG 118
            :.|:||::|||.|..||:   ||:       .|.:.|..|.....|::  :.||....|..||.
Human   151 NKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYS--NDLNSMAGSPVSSY- 212

  Fly   119 LDTSHMADSSGGGNYN 134
                    ||..|:|:
Human   213 --------SSDEGSYD 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH54F	NP_477302.1	HLH	32..83	CDD:278439	17/53 (32%)
ASCL1	NP_004307.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..98		6/11 (55%)
		bHLH_TS_ASCL1_Mash1	115..185	CDD:381585	22/69 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810