DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH54F and TCF23

DIOPT Version :9

Sequence 1:	NP_477302.1	Gene:	HLH54F / 37027	FlyBaseID:	FBgn0022740	Length:	242	Species:	Drosophila melanogaster
Sequence 2:	NP_786951.1	Gene:	TCF23 / 150921	HGNCID:	18602	Length:	214	Species:	Homo sapiens

Alignment Length:	145	Identity:	44/145 - (30%)
Similarity:	54/145 - (37%)	Gaps:	36/145 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ASSQSSQPPVQRNAANARERMRMRVLSSAYGRLKTKLPNIPPDTKLSKLDTLRLATLYIKQLITA 86
            |..:|...|  .||  ||||.|:|.|..|:..|:..||.:||||||||||.|.||..||..|
Human    71 ALGRSEASP--ENA--ARERSRVRTLRQAFLALQAALPAVPPDTKLSKLDVLVLAASYIAHL--- 128

  Fly    87 VETGSHSQNHPHNHNQHHSLNHSHSSTTSSEGLDTSHMADSSGGGNYNFHNNGHGMSWPFEFHQS 151
            ..|..|....|........|.:.|..                             ..||......
Human   129 TRTLGHELPGPAWPPFLRGLRYLHPL-----------------------------KKWPMRSRLY 164

  Fly   152 SRSLAFAPSSSTTSS 166
            :..|.::...|||:|
Human   165 AGGLGYSDLDSTTAS 179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH54F	NP_477302.1	HLH	32..83	CDD:278439	28/50 (56%)
TCF23	NP_786951.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..86		7/18 (39%)
		HLH	83..132	CDD:197674	27/51 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..214		4/6 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149580
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740