DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sardh and Dmgdh

DIOPT Version :9

Sequence 1:	NP_611263.1	Gene:	Sardh / 37026	FlyBaseID:	FBgn0034276	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_083048.1	Gene:	Dmgdh / 74129	MGIID:	1921379	Length:	869	Species:	Mus musculus

Alignment Length:	877	Identity:	265/877 - (30%)
Similarity:	425/877 - (48%)	Gaps:	73/877 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LQQASRRGISKQVREDGGARREPSGFLPGAADVVVIGGGSAGCHTLYHLARRGVK-AVLLERAQL 70
            |:.:.||..|..:||...:...|..: ...|:.|:||||..|....||||:.|:: .||:|:::|
Mouse    14 LRGSPRRPSSAGLREGQESPASPPEW-KDRAETVIIGGGCVGVSLAYHLAKAGMRDVVLMEKSEL 77

  Fly    71 TAGTTWHTAGLLWRLRPNDVDIQLLANSRRMLQQLEEETELDPGWIQNGGIFIAHNETRLDEYRR 135
            |||:|||.|||.....|.....::..:|.::.::|||||....|:.|.|.|.:|....|:||::.
Mouse    78 TAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYERLEEETGQVVGFHQPGSIRLATTPVRVDEFKY 142

  Fly   136 LATVGSALGIENQVLSPEDTQKLFPLLDPSAFVGALYSPGDGVMDPAMLCAALKKAATNLGAQVI 200
            ..|..:....|..::.||...:|||||:.:..:..||:||||.:||..|..||...|...||.:.
Mouse   143 QMTRTNWHATEQYIIEPEKIHELFPLLNMNKILAGLYNPGDGHIDPYSLTMALAAGARKYGALLK 207

  Fly   201 ENCGVDDLLLEQTARGKKVVGVSTPFGDIKAEKVVNATGVWGRDLVARHGTHLPLVPMKHAYIVS 265
            ....|..|    ..|......|.||.|.::|.::|||.|.|.|::....|...||:|::|.|:|:
Mouse   208 YPAPVTSL----KPRPDGTWDVETPQGSVRANRIVNAAGFWAREVGKMIGLDHPLIPVQHQYVVT 268

  Fly   266 ESIPGV----RGLPNIRDHDYSTYFRIQGDAICMGGYEPNPIL-------LEPVPKDFHFGLYEL 319
            .:||.|    |.||.:||.:.|.|.|.:.|.:..|.||....:       ...||..|...|:|.
Mouse   269 STIPEVKALKRELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKLQASWVTHGVPPGFGKELFES 333

  Fly   320 DWSVFETHVEGAQKLCPSYAKYGVKSTVCGPESFTPDHKPLMGPDPNLDGLYHNCGFNSAGMMFG 384
            |......|:|.|.::.|...|..:.:.|.||.:::||..|::||...:...:...|| ..|::..
Mouse   334 DLDRISDHLEAAMEMIPVLKKADIINVVNGPITYSPDILPMVGPHQGVRNYWVATGF-GYGIIHA 397

  Fly   385 GGCGEQTALWVIQGQPDLPMFGFDLRRFTQEQGK--AIQWIREKSHESYVKNYSMVFKYDQPLAG 447
            ||.|:..:.|::.|:|...:...|..|:    ||  ..|:...|:.|||..|..:.:..::..||
Mouse   398 GGVGKFLSDWILHGEPPFDLIELDPNRY----GKWTTTQYTEAKARESYGFNNIVGYPKEERFAG 458

  Fly   448 RDFQKDPLHDEMMKAGAVMEEKQGWERPGFFLPTGSKKAVVQPYDWYGSYVHQRHKDSEYERVLD 512
            |..|:.....:.:|:...|....|||:|.:|...|                    :|::|....
Mouse   459 RPTQRVSGLYKTLKSKCSMGFHAGWEQPHWFYKPG--------------------QDTQYRPSF- 502

  Fly   513 GDLHYSRFSEYHDLIGSEALACRNNAVVFNMSYFAKLLLDGPQAQEAADWLFSANTNRDPSKTVY 577
                  |.:.:.:.:|||.........|.::|.|.|..:.|..:.:..|.|| ||.......|..
Mouse   503 ------RRTNWFEPVGSEYKQVMQRVGVIDLSPFGKFNIKGRDSTQLLDHLF-ANVIPKVGFTNI 560

  Fly   578 TCALNDAGGVEADVTISRLAPGSGEVYNPKINGQGFYIVAGGASAFYTYSVLLAEIRRKGFNASL 642
            :..|...|.|.|::|:|:.:||.            |.::.|..|..:....:.....|.|::..:
Mouse   561 SHMLTPRGRVYAELTVSQQSPGE------------FLLITGSGSELHDLRWIEEAAFRGGYDVEI 613

  Fly   643 KDLTAELGVISIQGPNSRKILQPLIDCDLSDEHVAPNSTRLAKFGDVGLRLLRVSFVGELGYELH 707
            :::|.|.||:.:.||.:|::||.|...||||:......|:.....|:.:..:|:|:.||||:||:
Mouse   614 QNITDEFGVLGVAGPYARRVLQKLTSEDLSDDAFKFLQTKSFNISDIPVTAIRISYTGELGWELY 678

  Fly   708 VPKKDCAAVYRSLMKAGAGEDLRNAGYRSLYSLSSEKGYHLWSFDLRPDDTPLEAGLGFTCR-KT 771
            ..::|.|.:|..:|.||..|.:.:.|..:|.:|..||.:..|..::..|..||||||.:..: ..
Mouse   679 HRREDSATLYERIMSAGQEEGIGDFGTYALNALRLEKAFRAWGSEMNCDTNPLEAGLEYFVKLNK 743

  Fly   772 GADYRGKAAIENQRAEGLKKRLVYLTL-RDQVPIWGLEGVYRNGEPVGILRRAEYAYTLGKSLGQ 835
            .||:.||.|::..:.||||:|||.||: .|.|...|.|.::..|:.||......|:|::.|||..
Mouse   744 PADFIGKQALKQIKTEGLKRRLVCLTVATDDVDPEGNESIWYKGKVVGNTTSGSYSYSIQKSLAF 808

  Fly   836 TYVSRPDGKIIDADYIRNGEYEVDILGKKYRA 867
            .||.....::       ..:.||::|||.|.|
Mouse   809 AYVPVQLSEV-------GQQVEVELLGKNYPA 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sardh	NP_611263.1	DadA	33..412	CDD:223737	128/390 (33%)
		NADB_Rossmann	37..>76	CDD:304358	19/39 (49%)
		nuc_hydro	203..>281	CDD:294156	29/81 (36%)
		FAO_M	398..449	CDD:292961	14/52 (27%)
		GcvT	446..884	CDD:223481	121/424 (29%)
		GCV_T	456..767	CDD:279857	82/310 (26%)
		GCV_T_C	774..867	CDD:285832	33/93 (35%)
Dmgdh	NP_083048.1	NADB_Rossmann	38..>83	CDD:304358	19/45 (42%)
		DadA	40..428	CDD:223737	130/396 (33%)
		FAO_M	410..465	CDD:292961	16/58 (28%)
		GCV_T	475..738	CDD:279857	81/302 (27%)
		GcvT	481..850	CDD:223481	115/400 (29%)
		GCV_T_C	746..838	CDD:285832	34/95 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53337
OrthoDB	1	1.010	-	-		D96522at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3396
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.860