Protein Alignment Sardh and Dmgdh

DIOPT Version :10

• Sequence 1: NP_611263.1
• Gene: Sardh / 37026
• FlyBaseID: FBgn0034276
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: NP_083048.1
• Gene: Dmgdh / 74129
• MGIID: 1921379
• Length: 869
• Species: Mus musculus
• Alignment Length: 877
• Identity: 265/877 - (30%)
• Similarity: 425/877 - (48%)
• Gaps: 73/877 - (8%)

  Fly     7 LQQASRRGISKQVREDGGARREPSGFLPGAADVVVIGGGSAGCHTLYHLARRGVK-AVLLERAQL 70
            |:.:.||..|..:||...:...|..: ...|:.|:||||..|....||||:.|:: .||:|:::|
Mouse    14 LRGSPRRPSSAGLREGQESPASPPEW-KDRAETVIIGGGCVGVSLAYHLAKAGMRDVVLMEKSEL 77

  Fly    71 TAGTTWHTAGLLWRLRPNDVDIQLLANSRRMLQQLEEETELDPGWIQNGGIFIAHNETRLDEYRR 135
            |||:|||.|||.....|.....::..:|.::.::|||||....|:.|.|.|.:|....|:||::.
Mouse    78 TAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYERLEEETGQVVGFHQPGSIRLATTPVRVDEFKY 142

  Fly   136 LATVGSALGIENQVLSPEDTQKLFPLLDPSAFVGALYSPGDGVMDPAMLCAALKKAATNLGAQVI 200
            ..|..:....|..::.||...:|||||:.:..:..||:||||.:||..|..||...|...||.:.
Mouse   143 QMTRTNWHATEQYIIEPEKIHELFPLLNMNKILAGLYNPGDGHIDPYSLTMALAAGARKYGALLK 207

  Fly   201 ENCGVDDLLLEQTARGKKVVGVSTPFGDIKAEKVVNATGVWGRDLVARHGTHLPLVPMKHAYIVS 265
            ....|..|    ..|......|.||.|.::|.::|||.|.|.|::....|...||:|::|.|:|:
Mouse   208 YPAPVTSL----KPRPDGTWDVETPQGSVRANRIVNAAGFWAREVGKMIGLDHPLIPVQHQYVVT 268

  Fly   266 ESIPGV----RGLPNIRDHDYSTYFRIQGDAICMGGYEPNPIL-------LEPVPKDFHFGLYEL 319
            .:||.|    |.||.:||.:.|.|.|.:.|.:..|.||....:       ...||..|...|:|.
Mouse   269 STIPEVKALKRELPVLRDLEGSYYLRQERDGLLFGPYESQEKMKLQASWVTHGVPPGFGKELFES 333

  Fly   320 DWSVFETHVEGAQKLCPSYAKYGVKSTVCGPESFTPDHKPLMGPDPNLDGLYHNCGFNSAGMMFG 384
            |......|:|.|.::.|...|..:.:.|.||.:::||..|::||...:...:...|| ..|::..
Mouse   334 DLDRISDHLEAAMEMIPVLKKADIINVVNGPITYSPDILPMVGPHQGVRNYWVATGF-GYGIIHA 397

  Fly   385 GGCGEQTALWVIQGQPDLPMFGFDLRRFTQEQGK--AIQWIREKSHESYVKNYSMVFKYDQPLAG 447
            ||.|:..:.|::.|:|...:...|..|:    ||  ..|:...|:.|||..|..:.:..::..||
Mouse   398 GGVGKFLSDWILHGEPPFDLIELDPNRY----GKWTTTQYTEAKARESYGFNNIVGYPKEERFAG 458

  Fly   448 RDFQKDPLHDEMMKAGAVMEEKQGWERPGFFLPTGSKKAVVQPYDWYGSYVHQRHKDSEYERVLD 512
            |..|:.....:.:|:...|....|||:|.:|...|                    :|::|....
Mouse   459 RPTQRVSGLYKTLKSKCSMGFHAGWEQPHWFYKPG--------------------QDTQYRPSF- 502

  Fly   513 GDLHYSRFSEYHDLIGSEALACRNNAVVFNMSYFAKLLLDGPQAQEAADWLFSANTNRDPSKTVY 577
                  |.:.:.:.:|||.........|.::|.|.|..:.|..:.:..|.|| ||.......|..
Mouse   503 ------RRTNWFEPVGSEYKQVMQRVGVIDLSPFGKFNIKGRDSTQLLDHLF-ANVIPKVGFTNI 560

  Fly   578 TCALNDAGGVEADVTISRLAPGSGEVYNPKINGQGFYIVAGGASAFYTYSVLLAEIRRKGFNASL 642
            :..|...|.|.|::|:|:.:||.            |.::.|..|..:....:.....|.|::..:
Mouse   561 SHMLTPRGRVYAELTVSQQSPGE------------FLLITGSGSELHDLRWIEEAAFRGGYDVEI 613

  Fly   643 KDLTAELGVISIQGPNSRKILQPLIDCDLSDEHVAPNSTRLAKFGDVGLRLLRVSFVGELGYELH 707
            :::|.|.||:.:.||.:|::||.|...||||:......|:.....|:.:..:|:|:.||||:||:
Mouse   614 QNITDEFGVLGVAGPYARRVLQKLTSEDLSDDAFKFLQTKSFNISDIPVTAIRISYTGELGWELY 678

  Fly   708 VPKKDCAAVYRSLMKAGAGEDLRNAGYRSLYSLSSEKGYHLWSFDLRPDDTPLEAGLGFTCR-KT 771
            ..::|.|.:|..:|.||..|.:.:.|..:|.:|..||.:..|..::..|..||||||.:..: ..
Mouse   679 HRREDSATLYERIMSAGQEEGIGDFGTYALNALRLEKAFRAWGSEMNCDTNPLEAGLEYFVKLNK 743

  Fly   772 GADYRGKAAIENQRAEGLKKRLVYLTL-RDQVPIWGLEGVYRNGEPVGILRRAEYAYTLGKSLGQ 835
            .||:.||.|::..:.||||:|||.||: .|.|...|.|.::..|:.||......|:|::.|||..
Mouse   744 PADFIGKQALKQIKTEGLKRRLVCLTVATDDVDPEGNESIWYKGKVVGNTTSGSYSYSIQKSLAF 808

  Fly   836 TYVSRPDGKIIDADYIRNGEYEVDILGKKYRA 867
            .||.....::       ..:.||::|||.|.|
Mouse   809 AYVPVQLSEV-------GQQVEVELLGKNYPA 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sardh	NP_611263.1	DadA	37..411	CDD:440429	128/385 (33%)
		FAO_M	398..450	CDD:465100	15/53 (28%)
		GcvT	447..882	CDD:440173	120/423 (28%)
Dmgdh	NP_083048.1	DadA	42..424	CDD:440429	128/386 (33%)
		FAO_M	410..465	CDD:465100	16/58 (28%)
		GcvT	481..850	CDD:440173	115/400 (29%)