DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sardh and PDPR

DIOPT Version :9

Sequence 1:	NP_611263.1	Gene:	Sardh / 37026	FlyBaseID:	FBgn0034276	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001309046.1	Gene:	PDPR / 55066	HGNCID:	30264	Length:	879	Species:	Homo sapiens

Alignment Length:	917	Identity:	269/917 - (29%)
Similarity:	421/917 - (45%)	Gaps:	108/917 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWRHRILQQASRRGIS------KQVREDGGARREPSGFLPGAADVVVIGGGSAGCHTLYHLARRG 59
            |..:|:|....|:..|      ...|....|....|..||..|.||:.|||..|....|||::.|
Human     1 MMFYRLLSIVGRQRASPGWQNWSSARNSTSAAEARSMALPTQAQVVICGGGITGTSVAYHLSKMG 65

  Fly    60 VK-AVLLERAQLTAGTTWHTAGLLWRLRPNDVDIQLLANSRRMLQQLEEETELDPGWIQNGGIFI 123
            .| .||||:.:|.||:|...||:|...|...::.::...|.::..|||:||.:..|:.:.|.||:
Human    66 WKDIVLLEQGRLAAGSTRFCAGILSTARHLTIEQKMADYSNKLYYQLEQETGIQTGYTRTGSIFL 130

  Fly   124 AHNETRLDEYRRLATVGSALGIENQVLSPEDTQKLFPLLDPSAFVGALYSPGDGVMDPAMLCAAL 188
            |..:.||...:|:....:.:||.::::||:...:|..||:....|||::.|.|.|:..|.:..||
Human   131 AQTQDRLISLKRINAGLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHVPEDAVVSSADVALAL 195

  Fly   189 KKAATNLGAQVIENCGVDDLLLEQTARGKKVVGVSTPFGDIKAEKVVNATGVWGRD--LVARHGT 251
            ..||:..|.|:.:...|    |....:..:|.||.|..|.|:.:..||..|.|..:  |......
Human   196 ASAASQNGVQIYDRTSV----LHVMVKKGQVTGVETDKGQIECQYFVNCAGQWAYELGLSNEEPV 256

  Fly   252 HLPLVPMKHAYIVSESI--PGVRGLPNIRDHDYSTYFRIQGDAICMGGYEPNPILLEPVPKDFHF 314
            .:||...:|.|:::..:  |.....|.|.|.|...|.|.....|..||:|.||   :|:   |..
Human   257 SIPLHACEHFYLLTRPLETPLQSSTPTIVDADGRIYIRNWQGGILSGGFEKNP---KPI---FTE 315

  Fly   315 GLYEL-------DWSVFETHVEGAQKLCPSYAKYGVKSTVCGPESFTPDHKPLMGPDPNLDGLYH 372
            |..:|       ||..||..:....:..|......:...|..||:||||.:.:||..|.:.|.:.
Human   316 GKNQLEIQNLQEDWDHFEPLLSSLLRRMPELETLEIMKLVNCPETFTPDMRCIMGESPAVQGYFV 380

  Fly   373 NCGFNSAGMMFGGGCGEQTALWVIQGQPDLPMFGFDLRRFTQEQGKAIQWIREKSHESYVKNYSM 437
            ..|.||||:.||||.|:..|.|::.|.|...::..||:||...|... .::|.:..|      .|
Human   381 LAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLKRFGALQSSR-TFLRHRVME------VM 438

  Fly   438 VFKYDQPL------AGRDFQKDPLHDEMMKAGAVMEEKQGWERPGFFLPTG-------SKKAVVQ 489
            ...||..:      .||..:..||:|.:...||...||.|:|||.:|:|..       ..|...:
Human   439 PLMYDLKVPRWDFQTGRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVPPDKDLLALEQSKTFYK 503

  Fly   490 PYDWYGSYVHQRHKDSEYERVLDGDLHYSRFSEYHDLIGSEALACRNNAVVFNMSYFAK--LLLD 552
            | ||:                              |::.||...|:....|.:||.|.|  :...
Human   504 P-DWF------------------------------DIVESEVKCCKEAVCVIDMSSFTKFEITST 537

  Fly   553 GPQAQEAADWLFSANTNRDPSKTVYTCALNDAGGVEADVTISRLAPGSGEVYNPKINGQGFYIVA 617
            |.||.|...:|||.:.:......|:|..||:.||.|.|.:|:||            |.:.|::::
Human   538 GDQALEVLQYLFSNDLDVPVGHIVHTGMLNEGGGYENDCSIARL------------NKRSFFMIS 590

  Fly   618 GGASAFYTYSVLLAEIRRKGFNASLKDLTAELGVISIQGPNSRKILQPLIDCDLSDEHVAPNSTR 682
            ......:.::.|...: .|..|..|:|:|.:...:::.||.:..:|..|....::.:|......:
Human   591 PTDQQVHCWAWLKKHM-PKDSNLLLEDVTWKYTALNLIGPRAVDVLSELSYAPMTPDHFPSLFCK 654

  Fly   683 LAKFGDV-GLRLLRVSFVGELGYELHVPKKDCAAVYRSLMKAGAGEDLRNAGYRSLYSLSSEKGY 746
            ....|.. |:|::.::..||.|:.|::|.:....||..:|..|....:|||||.:|.||..||.:
Human   655 EMSVGYANGIRVMSMTHTGEPGFMLYIPIEYALHVYNEVMSVGQKYGIRNAGYYALRSLRIEKFF 719

  Fly   747 HLWSFDLRPDDTPLEAGLGFTCR-KTGADYRGKAAIENQRAEGLKKRLVYLTLRDQ------VPI 804
            ..|..|:....||||.|.....: :.|.|:.|:.|:..|:..|:.|||....|.|.      .|.
Human   720 AFWGQDINNLTTPLECGRESRVKLEKGMDFIGRDALLQQKQNGVYKRLTMFILDDHDSDLDLWPW 784

  Fly   805 WGLEGVYRNGEPVGILRRAEYAYTLGKSLGQTYV---SRPDG--KIIDADYIRNGEYEVDILGKK 864
            || |.:||||:.||....:.|:|:|.:.:...:|   |...|  :::.||:|..||||:||.|.:
Human   785 WG-EPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHNFSEDTGEEQVVTADFINRGEYEIDIAGYR 848

  Fly   865 YRADCHL 871
            ::|...|
Human   849 FQAKAKL 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sardh	NP_611263.1	DadA	33..412	CDD:223737	126/390 (32%)
		NADB_Rossmann	37..>76	CDD:304358	19/39 (49%)
		nuc_hydro	203..>281	CDD:294156	21/81 (26%)
		FAO_M	398..449	CDD:292961	13/56 (23%)
		GcvT	446..884	CDD:223481	127/448 (28%)
		GCV_T	456..767	CDD:279857	84/320 (26%)
		GCV_T_C	774..867	CDD:285832	36/103 (35%)
PDPR	NP_001309046.1	NADB_Rossmann	5..>74	CDD:304358	24/68 (35%)
		DadA	39..426	CDD:223737	129/396 (33%)
		FAO_M	405..460	CDD:292961	14/61 (23%)
		GcvT	453..830	CDD:223481	115/421 (27%)
		GCV_T	463..736	CDD:279857	83/316 (26%)
		GCV_T_C	748..852	CDD:285832	36/104 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D96522at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820