DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sardh and L2HGDH

DIOPT Version :9

Sequence 1:	NP_611263.1	Gene:	Sardh / 37026	FlyBaseID:	FBgn0034276	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001286076.1	Gene:	L2HGDH / 35156	FlyBaseID:	FBgn0032729	Length:	455	Species:	Drosophila melanogaster

Alignment Length:	434	Identity:	92/434 - (21%)
Similarity:	160/434 - (36%)	Gaps:	106/434 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RILQQASRR-----GISKQVREDGGARR-EPSGFLPGAADVVVIGGGSAGCHTLYHLARR--GVK 61
            |:|.|..||     |::.........:| :.|....|..|:||:|||..|..:...:..|  .:|
  Fly     5 RLLVQGLRRSLLNVGVAAPNESTATHKRSQHSSSSCGDYDLVVVGGGIVGAASAREIVLRHPSLK 69

  Fly    62 AVLLER-AQLTAGTTWHTAGLLWR---LRPNDVDIQLLANSRRMLQQLEEETELDPGWIQNGGIF 122
            ..:||: .:|....:.|.:|::..   .:|..:..:|......:.....:|.::.  :.:.|.:.
  Fly    70 VAVLEKECKLAKHQSGHNSGVIHAGIYYKPGTLKARLCVEGMHLAYAYLDEKKIP--YKKTGKLI 132

  Fly   123 IAHNETRLDEYRRLATVGSALGIEN-QVLSPEDTQKLFPLLDPSAFVGALYSPGDGVMDPAMLCA 186
            :|.:|..:...:.|...|.|..:.: :::...:.|::.|....   |.||:||..|::|..::
  Fly   133 VATDEKEVKLLKDLEKRGIANNVPDLRMIEGSEIQEIEPYCQG---VMALHSPHTGIVDWGLV-- 192

  Fly   187 ALKKAATNLGAQVIENCGVDDLLLE-------------------------QTARGKKVVGVSTPF 226
                  |....|..:.|| .|:.|:                         ||.|.|.|:......
  Fly   193 ------TEHYGQDFKQCG-GDIYLDFNVSKFTETKEGTDYPVTIHGAKPGQTVRTKNVLTCGGLQ 250

  Fly   227 GDIKAEKVVNATGVWGRD--LVARHGTHLPLVPMKHAYIVSESIPGVRGLPNIRDHDYSTYF--R 287
            .|:.|||    ||. .||  :|...|.:|.|...|...:.....|    :|:.|......:|  |
  Fly   251 SDLLAEK----TGC-PRDPRIVPFRGEYLLLTKEKQHMVKGNIYP----VPDPRFPFLGVHFTPR 306

  Fly   288 IQGDAICMGGYEPNPIL--------------------------LEPVPKDFHFGLYELDWSVF-E 325
            :.| :|.:|   ||.:|                          ::...|...|||.|:..|.| .
  Fly   307 MDG-SIWLG---PNAVLALKREGYTWGDINLFELFDALRYPGFVKMASKYIGFGLSEMSKSWFIN 367

  Fly   326 THVEGAQKLCPSYAKYGVKSTVCGPESFTPDHKPLMGPDPNLDG 369
            ..::..||..|...:|.::....|..:...|          |||
  Fly   368 LQIKALQKYIPDITEYDIQRGPAGVRAQAMD----------LDG 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sardh	NP_611263.1	DadA	33..412	CDD:223737	84/400 (21%)
		NADB_Rossmann	37..>76	CDD:304358	12/41 (29%)
		nuc_hydro	203..>281	CDD:294156	25/104 (24%)
		FAO_M	398..449	CDD:292961
		GcvT	446..884	CDD:223481
		GCV_T	456..767	CDD:279857
		GCV_T_C	774..867	CDD:285832
L2HGDH	NP_001286076.1	PRK11728	56..447	CDD:183292	76/383 (20%)
L2HGDH	NP_001286076.1	NADB_Rossmann	69..440	CDD:304358	75/370 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456419
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930